ID E3RUT1_PYRTT Unreviewed; 712 AA.
AC E3RUT1;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 03-MAY-2023, entry version 49.
DE RecName: Full=Eukaryotic translation initiation factor 2A {ECO:0000256|ARBA:ARBA00013819, ECO:0000256|PIRNR:PIRNR017222};
DE Short=eIF-2A {ECO:0000256|PIRNR:PIRNR017222};
GN ORFNames=PTT_12871 {ECO:0000313|EMBL:EFQ90498.1};
OS Pyrenophora teres f. teres (strain 0-1) (Barley net blotch fungus)
OS (Drechslera teres f. teres).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae;
OC Pyrenophora.
OX NCBI_TaxID=861557 {ECO:0000313|Proteomes:UP000001067};
RN [1] {ECO:0000313|EMBL:EFQ90498.1, ECO:0000313|Proteomes:UP000001067}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0-1 {ECO:0000313|EMBL:EFQ90498.1,
RC ECO:0000313|Proteomes:UP000001067};
RX PubMed=21067574; DOI=10.1186/gb-2010-11-11-r109;
RA Ellwood S.R., Liu Z., Syme R.A., Lai Z., Hane J.K., Keiper F., Moffat C.S.,
RA Oliver R.P., Friesen T.L.;
RT "A first genome assembly of the barley fungal pathogen Pyrenophora teres f.
RT teres.";
RL Genome Biol. 11:R109.1-R109.14(2010).
CC -!- FUNCTION: Functions in the early steps of protein synthesis of a small
CC number of specific mRNAs. Acts by directing the binding of methionyl-
CC tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it
CC binds methionyl-tRNAi to 40S subunits in a codon-dependent manner,
CC whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a
CC GTP-dependent manner. {ECO:0000256|PIRNR:PIRNR017222}.
CC -!- SIMILARITY: Belongs to the WD repeat EIF2A family.
CC {ECO:0000256|ARBA:ARBA00009573, ECO:0000256|PIRNR:PIRNR017222}.
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DR EMBL; GL535179; EFQ90498.1; -; Genomic_DNA.
DR RefSeq; XP_003301386.1; XM_003301338.1.
DR AlphaFoldDB; E3RUT1; -.
DR STRING; 861557.E3RUT1; -.
DR EnsemblFungi; EFQ90498; EFQ90498; PTT_12871.
DR KEGG; pte:PTT_12871; -.
DR eggNOG; KOG2315; Eukaryota.
DR HOGENOM; CLU_013809_0_1_1; -.
DR OrthoDB; 22264at2759; -.
DR Proteomes; UP000001067; Unassembled WGS sequence.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR011387; TIF2A.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13227; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR PANTHER; PTHR13227:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR Pfam; PF08662; eIF2A; 1.
DR PIRSF; PIRSF017222; eIF2A; 2.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000256|PIRNR:PIRNR017222};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|PIRNR:PIRNR017222};
KW Reference proteome {ECO:0000313|Proteomes:UP000001067};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845,
KW ECO:0000256|PIRNR:PIRNR017222}.
FT DOMAIN 217..411
FT /note="Translation initiation factor beta propellor-like"
FT /evidence="ECO:0000259|Pfam:PF08662"
FT REGION 444..663
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..604
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..637
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 712 AA; 78177 MW; DB4E50F193630CDE CRC64;
MAVPTQLAYR SAKGIGLFNA APVYEALPGF VRPEGNLRCC CYSPDSKYFA WATPEQVSVI
DASAGHIITI LPTPNVYELG FSPLGTYLIT WQRPSKDDDG NAVKNLRVWK TLSDEAEDDG
SRAVIGEYVQ KNQNGWNLQY TSDEKFCARV VTNEVQFFQS NDLRNPWNKL RVEGVTDMAL
SPGKNHSVAV FVPERKGMPA AVKVFQVPQF SQPVSQKTFF KGDKVQLKWN DLGTSLIVLA
QTEVDKTNKS YYGETNMYIL SANGTFDSRI QLDKEGPIHD VSWSPNSKEF GVTYGYMPAK
TTIFNQRAVA QHSFDLGPRN TILFSPHGRF VIVAGFGNLA GDMDIYDLER NFAKVCHVKT
SNSTYCEWSP DGQHILTATT SPRLRVDNGI RIYHVSGGLM YNEDMAELYH VVWRPQPTSM
FPLTDPLTTV PTPHSSALAY LSTQKTPSKP AGAYRPPGAR GTATPLHFKR EDEGGAAYTN
TGVSSTNVGF ANGFGKPRRR EVPGAEAAEL PPGAAPGGGV SLTGAQDGDG ELSKAALKNK
KKREAKKARE AADKAAGLGT EGANPPNGAN GGRSPERRQR SRSKSGYEQH SRSASQQRNF
GNSPNREARE ARQEGNPRQN PRQQRAAQQT QPQAPPPIQT ENQGPPPDLT VTSPGDGNPQ
DKKIRGLLKK MRAIDELKMR QASGEKLEDT QVKKISTETQ IKKELQGLGY RE
//
