ID E3TEA8_ICTPU Unreviewed; 285 AA.
AC E3TEA8;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=GPN-loop GTPase 3 {ECO:0000256|ARBA:ARBA00014587, ECO:0000256|RuleBase:RU365059};
GN Name=GPN3 {ECO:0000313|EMBL:ADO28644.1};
GN Synonyms=gpn3 {ECO:0000313|RefSeq:NP_001187440.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|EMBL:ADO28644.1};
RN [1] {ECO:0000313|EMBL:ADO28644.1, ECO:0000313|RefSeq:NP_001187440.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20634964; DOI=10.1371/journal.pone.0011546;
RA Chen F., Lee Y., Jiang Y., Wang S., Peatman E., Abernathy J., Liu H.,
RA Liu S., Kucuktas H., Ke C., Liu Z.;
RT "Identification and characterization of full-length cDNAs in channel
RT catfish (Ictalurus punctatus) and blue catfish (Ictalurus furcatus).";
RL PLoS ONE 5:E11546-E11546(2010).
RN [2] {ECO:0000313|RefSeq:NP_001187440.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Small GTPase required for proper localization of RNA
CC polymerase II (RNAPII). May act at an RNAP assembly step prior to
CC nuclear import. {ECO:0000256|ARBA:ARBA00002411}.
CC -!- FUNCTION: Small GTPase required for proper nuclear import of RNA
CC polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly
CC step prior to nuclear import. {ECO:0000256|RuleBase:RU365059}.
CC -!- SUBUNIT: Binds to RNA polymerase II (RNAPII).
CC {ECO:0000256|RuleBase:RU365059}.
CC -!- SIMILARITY: Belongs to the GPN-loop GTPase family.
CC {ECO:0000256|ARBA:ARBA00005290, ECO:0000256|RuleBase:RU365059}.
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DR EMBL; GU588688; ADO28644.1; -; mRNA.
DR RefSeq; NP_001187440.1; NM_001200511.1.
DR STRING; 7998.ENSIPUP00000019584; -.
DR Ensembl; ENSIPUT00000020433; ENSIPUP00000019584; ENSIPUG00000013244.
DR GeneID; 100528241; -.
DR KEGG; ipu:100528241; -.
DR CTD; 51184; -.
DR OMA; HTEDDYI; -.
DR OrthoDB; 168004at2759; -.
DR Proteomes; UP000221080; Chromosome 18.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd17872; GPN3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR004130; Gpn.
DR InterPro; IPR030228; Gpn3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR21231:SF7; GPN-LOOP GTPASE 3; 1.
DR PANTHER; PTHR21231; XPA-BINDING PROTEIN 1-RELATED; 1.
DR Pfam; PF03029; ATP_bind_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 2: Evidence at transcript level;
KW GTP-binding {ECO:0000256|RuleBase:RU365059};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU365059};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU365059}.
FT REGION 259..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 285 AA; 32804 MW; EB8E0263B08F76E0 CRC64;
MPRYAQLVMG PAGSGKSTYC STMIQHAEAI NRSIQVINLD PAAEHFNYPV MADIRELIQV
DDVMEDDSLR FGPNGGLVFC MEYFASNFDW LEESLGHVED DYILFDCPGQ IELYTHLPVM
KHLVEQLQQW EFRVCGVFLV DSQFMVESFK FISGVMAALS AMVALEIPQV NIMTKMDLLS
PKAKKEIEKY LDPDMYSMME DSSATMRSKK FMKLTKAICG LIDDYSMVRF LPFDRTDEEG
INIVLQHIDF SIQYGEDLEF KEPKEDDEEP GNQNYDEYFQ DRVDS
//
