ID E3TFY4_ICTPU Unreviewed; 201 AA.
AC E3TFY4;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=ADP-ribosylation factor-related protein 1 {ECO:0000256|ARBA:ARBA00039478};
GN Name=ARFRP {ECO:0000313|EMBL:ADO29220.1};
GN Synonyms=arfrp {ECO:0000313|RefSeq:NP_001187860.1}, arfrp1
GN {ECO:0000313|RefSeq:NP_001187860.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|EMBL:ADO29220.1};
RN [1] {ECO:0000313|EMBL:ADO29220.1, ECO:0000313|RefSeq:NP_001187860.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20634964; DOI=10.1371/journal.pone.0011546;
RA Chen F., Lee Y., Jiang Y., Wang S., Peatman E., Abernathy J., Liu H.,
RA Liu S., Kucuktas H., Ke C., Liu Z.;
RT "Identification and characterization of full-length cDNAs in channel
RT catfish (Ictalurus punctatus) and blue catfish (Ictalurus furcatus).";
RL PLoS ONE 5:E11546-E11546(2010).
RN [2] {ECO:0000313|RefSeq:NP_001187860.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Trans-Golgi-associated GTPase that regulates protein sorting.
CC Controls the targeting of ARL1 and its effector to the trans-Golgi.
CC Required for the lipidation of chylomicrons in the intestine and
CC required for VLDL lipidation in the liver.
CC {ECO:0000256|ARBA:ARBA00037377}.
CC -!- SUBUNIT: Interacts with SYS1. {ECO:0000256|ARBA:ARBA00038765}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC {ECO:0000256|ARBA:ARBA00010290, ECO:0000256|RuleBase:RU003925}.
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DR EMBL; GU589269; ADO29220.1; -; mRNA.
DR RefSeq; NP_001187860.1; NM_001200931.1.
DR STRING; 7998.ENSIPUP00000036569; -.
DR GeneID; 100528661; -.
DR KEGG; ipu:100528661; -.
DR CTD; 10139; -.
DR Proteomes; UP000221080; Chromosome 11.
DR GO; GO:0003925; F:G protein activity; IEA:UniProtKB-EC.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR CDD; cd04160; Arfrp1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR45909; ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1; 1.
DR PANTHER; PTHR45909:SF1; ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1; 1.
DR Pfam; PF00025; Arf; 1.
DR PRINTS; PR00328; SAR1GTPBP.
DR SMART; SM00177; ARF; 1.
DR SMART; SM00178; SAR; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51417; ARF; 1.
PE 2: Evidence at transcript level;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU003925};
KW Hydrolase {ECO:0000313|EMBL:ADO29220.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003925}.
SQ SEQUENCE 201 AA; 22581 MW; F5DF67AA0AFDDAFA CRC64;
MYTLLSGLYK YMFQKEEYCV LILGLDNAGK TTFLEQTKTK FCKNYKGMSL SKITTTVGLN
IGTIDVGKAR LMFWDLGGQD ELQSLWDKYY AESHGVIYVI DSTDEERLAE SKDAFEKMIS
SEALEGVLLL VLANKQDVEN CLSVPDIKTA FSDCAPKIGK RDCLVQPCTA LTGQGVNEGI
EWMVKCVVRN IHRPPRQKDI T
//
