ID   E3TFZ9_ICTPU            Unreviewed;       278 AA.
AC   E3TFZ9;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   RecName: Full=Aspartate dehydrogenase domain-containing protein {ECO:0000256|ARBA:ARBA00020169};
GN   Name=ASPD {ECO:0000313|EMBL:ADO29235.1};
GN   Synonyms=aspd {ECO:0000313|RefSeq:NP_001188210.1}, aspdh
GN   {ECO:0000313|RefSeq:NP_001188210.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|EMBL:ADO29235.1};
RN   [1] {ECO:0000313|EMBL:ADO29235.1, ECO:0000313|RefSeq:NP_001188210.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20634964; DOI=10.1371/journal.pone.0011546;
RA   Chen F., Lee Y., Jiang Y., Wang S., Peatman E., Abernathy J., Liu H.,
RA   Liu S., Kucuktas H., Ke C., Liu Z.;
RT   "Identification and characterization of full-length cDNAs in channel
RT   catfish (Ictalurus punctatus) and blue catfish (Ictalurus furcatus).";
RL   PLoS ONE 5:E11546-E11546(2010).
RN   [2] {ECO:0000313|RefSeq:NP_001188210.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the L-aspartate dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00008331}.
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DR   EMBL; GU589284; ADO29235.1; -; mRNA.
DR   RefSeq; NP_001188210.1; NM_001201281.1.
DR   GeneID; 100529011; -.
DR   KEGG; ipu:100529011; -.
DR   CTD; 554235; -.
DR   OrthoDB; 2879851at2759; -.
DR   Proteomes; UP000221080; Chromosome 2.
DR   GO; GO:0033735; F:aspartate dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009435; P:NAD biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR002811; Asp_DH.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR31873:SF6; ASPARTATE DEHYDROGENASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR31873; L-ASPARTATE DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF01958; Asp_DH_C; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   2: Evidence at transcript level;
KW   Oxidoreductase {ECO:0000313|EMBL:ADO29235.1}.
FT   DOMAIN          14..125
FT                   /note="Aspartate/homoserine dehydrogenase NAD-binding"
FT                   /evidence="ECO:0000259|Pfam:PF03447"
FT   DOMAIN          173..257
FT                   /note="Aspartate dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF01958"
SQ   SEQUENCE   278 AA;  29879 MW;  2042086A27CBDC9B CRC64;
     MTDRSPPVRV GIVGYGHLGQ FLVERIQKEG LEVGLGLAFV WNRNADKLSG SVPNDLVLTE
     LSDFTHKNAD VIVEVCHPQI VKDFGGRFLS HAHFLVGSPS ALSDSQLNEE LRLIAKQHGH
     TLYVPSGALW GGQDIQRLND SGLLKALSVR MSKHPSCFRL AGNLRSDWSE REGRRVIFHG
     SVAELCPVAP NNVDTMAAAA IAASTLGFSG VTGEIVSDTA LADYHLVEVE VTGSDGFSVK
     TVRRNPAKLG AVTGSATYSS FWSSLLVCKG HGGRVYLC
//