ID E3TGG8_ICTPU Unreviewed; 77 AA.
AC E3TGG8;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Probable pancreatic secretory proteinase inhibitor {ECO:0000313|EMBL:ADO29404.1};
DE SubName: Full=Serine peptidase inhibitor, Kazal type 4 precursor {ECO:0000313|RefSeq:NP_001187993.1};
GN Name=ISK1 {ECO:0000313|EMBL:ADO29404.1};
GN Synonyms=isk1 {ECO:0000313|RefSeq:NP_001187993.1}, spink4
GN {ECO:0000313|RefSeq:NP_001187993.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|EMBL:ADO29404.1};
RN [1] {ECO:0000313|EMBL:ADO29404.1, ECO:0000313|RefSeq:NP_001187993.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20634964; DOI=10.1371/journal.pone.0011546;
RA Chen F., Lee Y., Jiang Y., Wang S., Peatman E., Abernathy J., Liu H.,
RA Liu S., Kucuktas H., Ke C., Liu Z.;
RT "Identification and characterization of full-length cDNAs in channel
RT catfish (Ictalurus punctatus) and blue catfish (Ictalurus furcatus).";
RL PLoS ONE 5:E11546-E11546(2010).
RN [2] {ECO:0000313|RefSeq:NP_001187993.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23127152; DOI=10.1186/1471-2164-13-595;
RA Liu S., Zhang Y., Zhou Z., Waldbieser G., Sun F., Lu J., Zhang J.,
RA Jiang Y., Zhang H., Wang X., Rajendran K.V., Khoo L., Kucuktas H.,
RA Peatman E., Liu Z.;
RT "Efficient assembly and annotation of the transcriptome of catfish by RNA-
RT Seq analysis of a doubled haploid homozygote.";
RL BMC Genomics 13:595-595(2012).
RN [3] {ECO:0000313|RefSeq:NP_001187993.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; GU589454; ADO29404.1; -; mRNA.
DR RefSeq; NP_001187993.1; NM_001201064.1.
DR GeneID; 100528794; -.
DR KEGG; ipu:100528794; -.
DR CTD; 27290; -.
DR OrthoDB; 2920086at2759; -.
DR Proteomes; UP000221080; Chromosome 29.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR CDD; cd01327; KAZAL_PSTI; 1.
DR Gene3D; 3.30.60.30; -; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR001239; Prot_inh_Kazal-m.
DR PANTHER; PTHR21312:SF28; KAZAL-LIKE DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR21312; SERINE PROTEASE INHIBITOR; 1.
DR Pfam; PF00050; Kazal_1; 1.
DR PRINTS; PR00290; KAZALINHBTR.
DR SMART; SM00280; KAZAL; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR PROSITE; PS00282; KAZAL_1; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 2: Evidence at transcript level;
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001187993.1}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..77
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001187993.1"
FT /id="PRO_5011323945"
FT DOMAIN 22..77
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
SQ SEQUENCE 77 AA; 8221 MW; 8B3DDAF0029F1802 CRC64;
MSILLFSVLI LLATGSQVSS ESYRKPQCSE MAEIMACPLN FAPVCGTDGN TYANECGLCV
QRLKTKTGIL IARDGSC
//
