ID   E4HGR1_9ACTN            Unreviewed;       426 AA.
AC   E4HGR1;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   24-JAN-2024, entry version 55.
DE   SubName: Full=Putative RIP metalloprotease RseP {ECO:0000313|EMBL:EFS93619.1};
GN   ORFNames=HMPREF9607_00073 {ECO:0000313|EMBL:EFS93619.1};
OS   Cutibacterium modestum HL044PA1.
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Propionibacteriaceae; Cutibacterium; Cutibacterium modestum.
OX   NCBI_TaxID=765109 {ECO:0000313|EMBL:EFS93619.1, ECO:0000313|Proteomes:UP000003179};
RN   [1] {ECO:0000313|EMBL:EFS93619.1, ECO:0000313|Proteomes:UP000003179}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HL044PA1 {ECO:0000313|EMBL:EFS93619.1,
RC   ECO:0000313|Proteomes:UP000003179};
RA   Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA   Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA   Hall O., Minx P., Tomlinson C., Mitreva M., Hou S., Chen J., Wollam A.,
RA   Pepin K.H., Johnson M., Bhonagiri V., Zhang X., Suruliraj S., Warren W.,
RA   Chinwalla A., Mardis E.R., Wilson R.K.;
RL   Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the peptidase M50B family.
CC       {ECO:0000256|ARBA:ARBA00007931}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFS93619.1}.
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DR   EMBL; ADZU01000003; EFS93619.1; -; Genomic_DNA.
DR   RefSeq; WP_002527000.1; NZ_GL383170.1.
DR   AlphaFoldDB; E4HGR1; -.
DR   GeneID; 73017503; -.
DR   PATRIC; fig|765109.3.peg.69; -.
DR   HOGENOM; CLU_025778_1_2_11; -.
DR   OrthoDB; 9782003at2; -.
DR   Proteomes; UP000003179; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00989; PDZ_metalloprotease; 1.
DR   CDD; cd06163; S2P-M50_PDZ_RseP-like; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR041489; PDZ_6.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR004387; Pept_M50_Zn.
DR   InterPro; IPR008915; Peptidase_M50.
DR   PANTHER; PTHR42837:SF2; MEMBRANE METALLOPROTEASE ARASP2, CHLOROPLASTIC-RELATED; 1.
DR   PANTHER; PTHR42837; REGULATOR OF SIGMA-E PROTEASE RSEP; 1.
DR   Pfam; PF17820; PDZ_6; 1.
DR   Pfam; PF02163; Peptidase_M50; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW   ECO:0000313|EMBL:EFS93619.1};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:EFS93619.1};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   TRANSMEM        7..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        122..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        337..356
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        399..420
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          142..226
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|SMART:SM00228"
SQ   SEQUENCE   426 AA;  45428 MW;  22A14FD41755F96C CRC64;
     MTVVIEVLAG IVFFSLIILS VLLHECGHFI PAKIFGVKVT EFFAGFGPKI WSFTRGETEY
     GFKWIPLGGY VRLVGMYPAT VHHHHGNRLT KLADEARAAE AEDITGADRG RLFSDKPVWQ
     RLIIMSGGIL TNLLLAFLLF WAVFGIHGRA AQTTTVAAVT PCVHSSQISG PCPSGDRRAP
     AAEAGVQAGD RIVSFNGRQV DSWSQLQEFI RDNGDGEARL GVKRHGDAVS LMPTRTLVTE
     VPDLNNPGRT VEAGYLGVSP TMVVVHSGPG DTVSQMWTMS KQSLSALARL PVLTWNVASD
     MVTGKARDAN SPMSIVGASR VAGDVAGNSQ LTMGDKIATG ASLLGGLNLF LFWFNVVPLP
     PMDGGHIAGA IYEACKRGLF KLAGKPDPGP ADTAMMLPVA WTIGALMLVM GLILVVADVV
     SPVKIF
//