ID E4HKD8_9ACTN Unreviewed; 422 AA.
AC E4HKD8;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=precorrin-2 dehydrogenase {ECO:0000256|ARBA:ARBA00012400};
DE EC=1.3.1.76 {ECO:0000256|ARBA:ARBA00012400};
GN Name=cbiX {ECO:0000313|EMBL:EFS92430.1};
GN ORFNames=HMPREF9607_01373 {ECO:0000313|EMBL:EFS92430.1};
OS Cutibacterium modestum HL044PA1.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Propionibacteriaceae; Cutibacterium; Cutibacterium modestum.
OX NCBI_TaxID=765109 {ECO:0000313|EMBL:EFS92430.1, ECO:0000313|Proteomes:UP000003179};
RN [1] {ECO:0000313|EMBL:EFS92430.1, ECO:0000313|Proteomes:UP000003179}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HL044PA1 {ECO:0000313|EMBL:EFS92430.1,
RC ECO:0000313|Proteomes:UP000003179};
RA Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA Hall O., Minx P., Tomlinson C., Mitreva M., Hou S., Chen J., Wollam A.,
RA Pepin K.H., Johnson M., Bhonagiri V., Zhang X., Suruliraj S., Warren W.,
RA Chinwalla A., Mardis E.R., Wilson R.K.;
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin;
CC Xref=Rhea:RHEA:15613, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945, ChEBI:CHEBI:58351, ChEBI:CHEBI:58827; EC=1.3.1.76;
CC Evidence={ECO:0000256|ARBA:ARBA00001156};
CC -!- PATHWAY: Porphyrin-containing compound metabolism; siroheme
CC biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.
CC {ECO:0000256|ARBA:ARBA00005010}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFS92430.1}.
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DR EMBL; ADZU01000023; EFS92430.1; -; Genomic_DNA.
DR RefSeq; WP_002546656.1; NZ_GL383182.1.
DR AlphaFoldDB; E4HKD8; -.
DR PATRIC; fig|765109.3.peg.1289; -.
DR HOGENOM; CLU_056929_0_1_11; -.
DR OrthoDB; 7345302at2; -.
DR UniPathway; UPA00262; UER00222.
DR Proteomes; UP000003179; Unassembled WGS sequence.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043115; F:precorrin-2 dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0019354; P:siroheme biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd03414; CbiX_SirB_C; 1.
DR CDD; cd03416; CbiX_SirB_N; 1.
DR Gene3D; 3.40.50.1400; -; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002762; CbiX-like.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006367; Sirohaem_synthase_N.
DR NCBIfam; TIGR01470; cysG_Nterm; 1.
DR PANTHER; PTHR33542; SIROHYDROCHLORIN FERROCHELATASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR33542:SF3; SIROHYDROCHLORIN FERROCHELATASE, CHLOROPLASTIC; 1.
DR Pfam; PF01903; CbiX; 2.
DR Pfam; PF13241; NAD_binding_7; 1.
DR SUPFAM; SSF53800; Chelatase; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:EFS92430.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
SQ SEQUENCE 422 AA; 45421 MW; BA16D8E6584F4189 CRC64;
MTDPLTSGTP LVIAAHGTRD EAGVAECRAL AERVARKLPG IPVELGFVEL AEPGIPEAVR
AAVAQAPDNP EGADGDEEAA VVVVPLMFNT GGHVREDIPE AIDEGRGDAR VMYSAPLLPD
VRMRKALSHR LVEALAVGDG REEWRPRDTS VVLVGRGALV PDANAAHYTL TRMFWEENDL
SRVEPAFIQV TRPSVPEALS ALAAQGADQI VVQGNFLFPG LLHVWMTEQV EAWQVSHPGV
EIRIASVIGD CDEVADVVVD RYREPLDEVG LGEGAPVYMS GLRLQGRKVL VVGAGHVAER
RVVRLLDAGA NVHVVAPNSG IQLTRMSRKG LVNLEHRAFR VEDLDGVWFV QALTNDPEVN
ALVAEEADRR GIFCVRGDKG CKGSAFTPAT QQAGGMTVSV VGDRTPRRSA RLRDEVLRAL
QG
//
