ID E4N2T0_KITSK Unreviewed; 786 AA.
AC E4N2T0;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Putative peptidase M09 family protein {ECO:0000313|EMBL:BAJ32464.1};
GN OrderedLocusNames=KSE_67060 {ECO:0000313|EMBL:BAJ32464.1};
OS Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304
OS / NBRC 14216 / KM-6054) (Streptomyces setae).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Kitasatospora.
OX NCBI_TaxID=452652 {ECO:0000313|EMBL:BAJ32464.1, ECO:0000313|Proteomes:UP000007076};
RN [1] {ECO:0000313|EMBL:BAJ32464.1, ECO:0000313|Proteomes:UP000007076}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 /
RC KM-6054 {ECO:0000313|Proteomes:UP000007076};
RX PubMed=21059706; DOI=10.1093/dnares/dsq026;
RA Ichikawa N., Oguchi A., Ikeda H., Ishikawa J., Kitani S., Watanabe Y.,
RA Nakamura S., Katano Y., Kishi E., Sasagawa M., Ankai A., Fukui S.,
RA Hashimoto Y., Kamata S., Otoguro M., Tanikawa S., Nihira T., Horinouchi S.,
RA Ohnishi Y., Hayakawa M., Kuzuyama T., Arisawa A., Nomoto F., Miura H.,
RA Takahashi Y., Fujita N.;
RT "Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary
RT snapshot of the family Streptomycetaceae.";
RL DNA Res. 17:393-406(2010).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; AP010968; BAJ32464.1; -; Genomic_DNA.
DR RefSeq; WP_014139760.1; NC_016109.1.
DR AlphaFoldDB; E4N2T0; -.
DR STRING; 452652.KSE_67060; -.
DR KEGG; ksk:KSE_67060; -.
DR PATRIC; fig|452652.3.peg.6727; -.
DR eggNOG; COG3975; Bacteria.
DR HOGENOM; CLU_359778_0_0_11; -.
DR Proteomes; UP000007076; Chromosome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 1.10.390.20; -; 1.
DR Gene3D; 3.40.30.160; Collagenase ColT, N-terminal domain; 1.
DR InterPro; IPR013661; Peptidase_M9_N_dom.
DR InterPro; IPR002169; Peptidase_M9A/M9B.
DR PANTHER; PTHR13062:SF9; A2M DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR13062; COLLAGENASE; 1.
DR Pfam; PF01752; Peptidase_M9; 1.
DR Pfam; PF08453; Peptidase_M9_N; 1.
DR PRINTS; PR00931; MICOLLPTASE.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000007076};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..786
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5039262493"
FT DOMAIN 119..281
FT /note="Peptidase M9 collagenase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08453"
FT REGION 68..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 513
FT /evidence="ECO:0000256|PIRSR:PIRSR602169-1"
SQ SEQUENCE 786 AA; 85380 MW; 0FA5C7A55DAB90DF CRC64;
MRSPRKTLLA AAIAASLALP LLQNAHAVAA DPATASTPAA TATAAAATAA PTGRTAYDEV
DHLAAAPATS APAPAGGAFT QDAHVPGLPD TAGRPAPTAG ETAGATVAGT GTTAAGVRCD
LNGLTGLGPR ALADFLADPA VTESCLQTLL WRWDARFATT MDAAHVQAVA AKAEQLAAGN
DPNLYQLWYF LHAAVYHDFT RDEIDLTTPA TTAPVQRAID AYLAAGRAFE PTAAAGLVMR
ELANTATAPG IREHNLPLVK RILGQFGPGT KVADSWEWGG AAFSALNISY LGIYNRDQAF
RANVAADADY RAAFRAFATA AQLKGTQNSW VARDAMNEYG RFSEISTLTA PITAEIGSLL
ADTGKTFGET SPQWIKVVGW ANTLKVCQQF DVCTSKYEAI LFPYTYKYDN GAIEVHTALD
KATVDQMYYA SKQVKSQFFR VLGTDTPLAG DPNDTLRIQL YPTRAAYEIY HPLLTGMGTE
NGGVYIERGA TFYTYQRTTA ESYLTLEELF RHEYVHYLNG RWATPGYFND PRWYAGSKTT
AMDEGTAEFF DGATRDQGVK VRQSLVAALT RDEANGIPRL SVGEVLHASY DDTPAFHFYN
YAGTFFEFLW NAHPALLREM YAYQRADDPA GYDAWRTRLS ADQNLNREYW AFLDEQIKQG
AAKALYVPKT AFTANGYLKY AYPSEVRDAF AKATSNTPEC KDNGDWDNKP MRFVCTGRIT
ANLVNSTNPD QVIKDMSGTV DYFLLQRTKG VANNLDDMNC YFGKVDVWPG GQAGTADYTC
EGPLRR
//
