ID E4NAE2_KITSK Unreviewed; 1109 AA.
AC E4NAE2;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Putative AfsR family transcriptional regulator {ECO:0000313|EMBL:BAJ28173.1};
GN OrderedLocusNames=KSE_23550 {ECO:0000313|EMBL:BAJ28173.1};
OS Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304
OS / NBRC 14216 / KM-6054) (Streptomyces setae).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Kitasatospora.
OX NCBI_TaxID=452652 {ECO:0000313|EMBL:BAJ28173.1, ECO:0000313|Proteomes:UP000007076};
RN [1] {ECO:0000313|EMBL:BAJ28173.1, ECO:0000313|Proteomes:UP000007076}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 /
RC KM-6054 {ECO:0000313|Proteomes:UP000007076};
RX PubMed=21059706; DOI=10.1093/dnares/dsq026;
RA Ichikawa N., Oguchi A., Ikeda H., Ishikawa J., Kitani S., Watanabe Y.,
RA Nakamura S., Katano Y., Kishi E., Sasagawa M., Ankai A., Fukui S.,
RA Hashimoto Y., Kamata S., Otoguro M., Tanikawa S., Nihira T., Horinouchi S.,
RA Ohnishi Y., Hayakawa M., Kuzuyama T., Arisawa A., Nomoto F., Miura H.,
RA Takahashi Y., Fujita N.;
RT "Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary
RT snapshot of the family Streptomycetaceae.";
RL DNA Res. 17:393-406(2010).
CC -!- SIMILARITY: Belongs to the AfsR/DnrI/RedD regulatory family.
CC {ECO:0000256|ARBA:ARBA00005820}.
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DR EMBL; AP010968; BAJ28173.1; -; Genomic_DNA.
DR RefSeq; WP_014135489.1; NC_016109.1.
DR AlphaFoldDB; E4NAE2; -.
DR STRING; 452652.KSE_23550; -.
DR KEGG; ksk:KSE_23550; -.
DR PATRIC; fig|452652.3.peg.2368; -.
DR eggNOG; COG3629; Bacteria.
DR eggNOG; COG3903; Bacteria.
DR HOGENOM; CLU_004665_1_3_11; -.
DR Proteomes; UP000007076; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd15831; BTAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR005158; BTAD.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR47691:SF3; HTH-TYPE TRANSCRIPTIONAL REGULATOR RV0890C-RELATED; 1.
DR PANTHER; PTHR47691; REGULATOR-RELATED; 1.
DR Pfam; PF03704; BTAD; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM01043; BTAD; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007076};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 16..88
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000259|SMART:SM00862"
FT DOMAIN 93..235
FT /note="Bacterial transcriptional activator"
FT /evidence="ECO:0000259|SMART:SM01043"
SQ SEQUENCE 1109 AA; 117846 MW; BAD9FFD9C7573F69 CRC64;
MHYGILGTTT AHHDDGTPVV LGGARLRALL AALVLREGRP VPAELLAEEV WADDPPQDAA
AALQTLVGRL RRTVGRAEVG SGPAGYWLTD PRTDVAEFRR RAADGVRALT GGDPAAAAEQ
LTAALALWRG PALADLPDRA APAARLEAQR AEARRHRLTA DLGLGRTAEV AAELAELCRD
HPFDERLQAL RLRALRAAGR TAEALGGYEE VRRTLAEELG TDPGPELRAL HRELLQAEPI
PAPAPAPAPA AVTVPAPAGN LRPGRTSFVG RDGELGAVAD ALAAGRLTTL TGPGGSGKTR
LSVEAGRREQ DAARWPGGVW QVELAPLEDP AAVPDAVASA LGLRETVLHT GGAVAEAIEG
TRKDPVSRLV DHLGRRRVLL LLDNCEHVVQ AAADLADRLL ADCPGVTVLA TSREPLGVPG
EAVLPVEPLP DPAALRLLAE RGAAARPGFR TDQDPEACAE VCRRLDGLPL AIELAAARLR
GLTPRQLADR LDSRFALLTA GSRTLLPRQQ TLRAVVDWSW DLLGTRERAV LRRLSVFAGG
CTLEAAEQVL ADGELVRRED VADLLLSLVD KSLVIVGLGE RPRYWMLETI HEYAAERLAE
AGEPGTGHRH TAHYRELART AYLGLHGPGQ LDELDRLDRE QENVRAALRR AVDGGQEQEG
LALVLSMAGY WMLRDYRAES RAWCEAVAAL GPDPYADGAP PPVPLTADPL DAPPPMTADL
LDEARRQLGL HRLIGMFSGD MSLLDDGRAL DTARRILETY TPDLPQSYRQ PVLSRVFTVF
LTGEMERTRA VMDDAVAGAR IHGGPLDLAF ALQLRARLLN DLAGSLDQAI ADSEEALALY
TGLGDRWGMA DALSGTAENA TKSGDAAQAE AAFRQAIALS EQLGAHQEVP MLRARLGEVL
AERDPAGGEA MVRQAVADAA GGGTDAEGAR MYGRLVLCNL AVRRGDHAEA LALLDELPAD
PGRRGPVPSV FAGIVTCIRG WVTARAGDPA TGLALARAGR RAMTEVEGGA TIFVEHMAMM
LMTPIAGTLV EYARLHGEPA AARRAAVLLG AHDGLSGMPG SFMERAEHAR CVAAARELLG
ADDYLASYEQ GGRLTLREAS ALMNDPGSF
//
