ID   E4NM99_HALBP            Unreviewed;       325 AA.
AC   E4NM99;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   27-MAR-2024, entry version 66.
DE   SubName: Full=3-isopropylmalate dehydrogenase {ECO:0000313|EMBL:ADQ67304.1};
DE            EC=1.1.1.85 {ECO:0000313|EMBL:ADQ67304.1};
GN   OrderedLocusNames=Hbor_17360 {ECO:0000313|EMBL:ADQ67304.1};
GN   ORFNames=C499_07650 {ECO:0000313|EMBL:ELY28519.1};
OS   Halogeometricum borinquense (strain ATCC 700274 / DSM 11551 / JCM 10706 /
OS   KCTC 4070 / PR3).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC   Haloferacaceae; Halogeometricum.
OX   NCBI_TaxID=469382 {ECO:0000313|EMBL:ADQ67304.1, ECO:0000313|Proteomes:UP000006663};
RN   [1] {ECO:0000313|EMBL:ADQ67304.1, ECO:0000313|Proteomes:UP000006663}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700274 / DSM 11551 / JCM 10706 / KCTC 4070 / PR3
RC   {ECO:0000313|Proteomes:UP000006663}, and PR 3
RC   {ECO:0000313|EMBL:ADQ67304.1};
RX   PubMed=21304651; DOI=10.4056/sigs.23264;
RA   Malfatti S., Tindall B.J., Schneider S., Fahnrich R., Lapidus A.,
RA   Labuttii K., Copeland A., Glavina Del Rio T., Nolan M., Chen F., Lucas S.,
RA   Tice H., Cheng J.F., Bruce D., Goodwin L., Pitluck S., Anderson I.,
RA   Pati A., Ivanova N., Mavromatis K., Chen A., Palaniappan K.,
RA   D'haeseleer P., Goker M., Bristow J., Eisen J.A., Markowitz V.,
RA   Hugenholtz P., Kyrpides N.C., Klenk H.P., Chain P.;
RT   "Complete genome sequence of Halogeometricum borinquense type strain
RT   (PR3).";
RL   Stand. Genomic Sci. 1:150-159(2009).
RN   [2] {ECO:0000313|EMBL:ELY28519.1, ECO:0000313|Proteomes:UP000011585}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 11551 {ECO:0000313|EMBL:ELY28519.1,
RC   ECO:0000313|Proteomes:UP000011585};
RX   PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA   Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA   Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT   "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT   strategies for static and dynamic osmo-response.";
RL   PLoS Genet. 10:E1004784-E1004784(2014).
CC   -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC       dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
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DR   EMBL; CP001690; ADQ67304.1; -; Genomic_DNA.
DR   EMBL; AOHT01000024; ELY28519.1; -; Genomic_DNA.
DR   RefSeq; WP_006054847.1; NZ_AOHT01000024.1.
DR   AlphaFoldDB; E4NM99; -.
DR   STRING; 469382.Hbor_17360; -.
DR   GeneID; 9993555; -.
DR   KEGG; hbo:Hbor_17360; -.
DR   PATRIC; fig|469382.19.peg.1496; -.
DR   eggNOG; arCOG01163; Archaea.
DR   HOGENOM; CLU_031953_0_1_2; -.
DR   OrthoDB; 6813at2157; -.
DR   Proteomes; UP000006663; Chromosome.
DR   Proteomes; UP000011585; Unassembled WGS sequence.
DR   GO; GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR   InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR   PANTHER; PTHR11835; DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE; 1.
DR   PANTHER; PTHR11835:SF34; ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR   Pfam; PF00180; Iso_dh; 1.
DR   SMART; SM01329; Iso_dh; 1.
DR   SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000313|EMBL:ADQ67304.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006663}.
FT   DOMAIN          4..320
FT                   /note="Isopropylmalate dehydrogenase-like"
FT                   /evidence="ECO:0000259|SMART:SM01329"
SQ   SEQUENCE   325 AA;  33722 MW;  746CB92E94B344B2 CRC64;
     MTEQIVVVEG DGIGAEVVPA AVDVLKAVGD FEFVEADAGD AVKAETGEAL PQETYDAVAD
     ADATLFGAAG ETAADVILPL REAVDSFVNV RPAKAYPGVD ALRPETDLVF LRENTEGVYS
     GHEDRLSDDL STLTRVVTTS ASEQLAEYAC DFVGGEGGSF QIAHKANVMR ETDGRFRDTI
     VSVADKRGVE VEEVLMDAFA TRVCLDPTQF DTIVCPNLAG DVLSDLAAGL VGGLGLLPSA
     NIGPDNALFE PVHGTAPDIA GEGIANPSAT ILSAAMLLEH LGYDDEGAAV REAVESTLAE
     GPCTPDLGGD AATEDVTKAI INKLD
//