ID E4Q2X9_CALOW Unreviewed; 735 AA.
AC E4Q2X9;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein {ECO:0000313|EMBL:ADQ04997.1};
GN OrderedLocusNames=Calow_1450 {ECO:0000313|EMBL:ADQ04997.1};
OS Caldicellulosiruptor owensensis (strain ATCC 700167 / DSM 13100 / OL).
OC Bacteria; Bacillota; Clostridia; Caldicellulosiruptorales;
OC Caldicellulosiruptoraceae; Caldicellulosiruptor.
OX NCBI_TaxID=632518 {ECO:0000313|EMBL:ADQ04997.1, ECO:0000313|Proteomes:UP000006889};
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=OL;
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M.,
RA Hauser L., Chang Y.-J., Jeffries C., Kyrpides N., Ivanova N.,
RA Mikhailova N., Blumer-Schuette S.E., Kelly R.M., Woyke T.;
RT "Complete sequence of Caldicellulosiruptor owensensis OL.";
RL Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADQ04997.1, ECO:0000313|Proteomes:UP000006889}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700167 / DSM 13100 / OL
RC {ECO:0000313|Proteomes:UP000006889};
RX PubMed=21216991; DOI=10.1128/JB.01515-10;
RA Blumer-Schuette S.E., Ozdemir I., Mistry D., Lucas S., Lapidus A.,
RA Cheng J.F., Goodwin L.A., Pitluck S., Land M.L., Hauser L.J., Woyke T.,
RA Mikhailova N., Pati A., Kyrpides N.C., Ivanova N., Detter J.C.,
RA Walston-Davenport K., Han S., Adams M.W., Kelly R.M.;
RT "Complete genome sequences for the anaerobic, extremely thermophilic plant
RT biomass-degrading bacteria Caldicellulosiruptor hydrothermalis,
RT Caldicellulosiruptor kristjanssonii, Caldicellulosiruptor kronotskyensis,
RT Caldicellulosiruptor owensenis, and Caldicellulosiruptor lactoaceticus.";
RL J. Bacteriol. 193:1483-1484(2011).
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DR EMBL; CP002216; ADQ04997.1; -; Genomic_DNA.
DR RefSeq; WP_013412357.1; NC_014657.1.
DR AlphaFoldDB; E4Q2X9; -.
DR STRING; 632518.Calow_1450; -.
DR KEGG; cow:Calow_1450; -.
DR eggNOG; COG0674; Bacteria.
DR eggNOG; COG1013; Bacteria.
DR HOGENOM; CLU_020913_0_0_9; -.
DR OrthoDB; 9794954at2; -.
DR Proteomes; UP000006889; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR CDD; cd03376; TPP_PFOR_porB_like; 1.
DR CDD; cd07034; TPP_PYR_PFOR_IOR-alpha_like; 1.
DR Gene3D; 3.40.50.920; -; 1.
DR Gene3D; 3.40.50.970; -; 3.
DR InterPro; IPR033412; PFOR_II.
DR InterPro; IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR PANTHER; PTHR32154; PYRUVATE-FLAVODOXIN OXIDOREDUCTASE-RELATED; 1.
DR PANTHER; PTHR32154:SF0; PYRUVATE-FLAVODOXIN OXIDOREDUCTASE-RELATED; 1.
DR Pfam; PF17147; PFOR_II; 1.
DR Pfam; PF01855; POR_N; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Electron transport {ECO:0000256|ARBA:ARBA00022982};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022485};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Pyruvate {ECO:0000313|EMBL:ADQ04997.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006889};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 19..245
FT /note="Pyruvate flavodoxin/ferredoxin oxidoreductase
FT pyrimidine binding"
FT /evidence="ECO:0000259|Pfam:PF01855"
FT DOMAIN 267..370
FT /note="Pyruvate:ferredoxin oxidoreductase core"
FT /evidence="ECO:0000259|Pfam:PF17147"
FT DOMAIN 517..635
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 735 AA; 82271 MW; 90BDE30D660166B9 CRC64;
MIKPQETIFE SGNEMAALAA SQINYHIMGY YPITPSTQIA EELDQMRADG LHDILLIAAD
GEHGAAGICY GASLGGGRVF NATSANGLMY ALEQLPVQSG TRFPMVLNLV TRSISGPLDI
KGDHSDLMFT LNTGWIILLA KDPQRVYDMN IMAVKIGEHP DVNLPVIVAY DGFFTSHQKR
VVSYFKNKED VQEFVGKLPP KRTVAIDPEN PVTIGPYMNE PDLINNKYQL SKAMDKAYEI
IPQVFEEFYK ISGRKYELVE GYKMEDAEIA IFVLNSTYDT ICEAVDILRQ RGIKAGVATT
NVLRPWPKKE IQELLKNVKL LAVLDRQESY GAKGGNMTIE IKATLQELEK GPKVISRIYG
LGGKDFFLED AINLFEDMNL VLEGKKEIPD FDYIGAYPGD ENYVPKRYMK PIKAEWTKNI
LLNTRDLTAM PKRIVPGHGA CPGCGIFPNL NLLLKGIEGD IVLLFHTGCG MVVTTAYPQT
AFRTTYVHNL FQNGAATLSG LVEMYNQRKK RGEIPDRDLT FILVTGDGGN DIGMGPTIGA
ALRNHKMIIF EYDNGGYMNT GYQLSYTTPY GASTSTSHVG KAQFGKATFH KDTPQIMAAT
NIPYVATVAE SDPIDFVKKA KKAQKIMREE GLVYIKALSA CPLNWGDEPS KERRVIQAAV
DCCFYPLYEI DHGKTTITYD PEKKGKKIPV IEWLSMMGRT KHLTRPEYKH IVEEFQAEVD
RRWERLKARH EHPLL
//
