ID E4RJP3_HALHG Unreviewed; 335 AA.
AC E4RJP3;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Isocitrate dehydrogenase (NAD(+)) {ECO:0000313|EMBL:ADQ15463.1};
DE EC=1.1.1.41 {ECO:0000313|EMBL:ADQ15463.1};
GN OrderedLocusNames=Halsa_2046 {ECO:0000313|EMBL:ADQ15463.1};
OS Halanaerobium hydrogeniformans (Halanaerobium sp. (strain sapolanicus)).
OC Bacteria; Bacillota; Clostridia; Halanaerobiales; Halanaerobiaceae;
OC Halanaerobium.
OX NCBI_TaxID=656519 {ECO:0000313|EMBL:ADQ15463.1, ECO:0000313|Proteomes:UP000007434};
RN [1] {ECO:0000313|EMBL:ADQ15463.1, ECO:0000313|Proteomes:UP000007434}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=sapolanicus {ECO:0000313|Proteomes:UP000007434};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M.,
RA Hauser L., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N.,
RA Begemann M.B., Mormile M.R., Wall J.D., Elias D.A., Woyke T.;
RT "Complete sequence of Halanaerobium sp. sapolanicus.";
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADQ15463.1, ECO:0000313|Proteomes:UP000007434}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=sapolanicus {ECO:0000313|Proteomes:UP000007434};
RX PubMed=21602336; DOI=10.1128/JB.05209-11;
RA Brown S.D., Begemann M.B., Mormile M.R., Wall J.D., Han C.S., Goodwin L.A.,
RA Pitluck S., Land M.L., Hauser L.J., Elias D.A.;
RT "Complete Genome Sequence of the Haloalkaliphilic, Hydrogen Producing
RT Halanaerobium hydrogenoformans.";
RL J. Bacteriol. 193:3682-3683(2011).
CC -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
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DR EMBL; CP002304; ADQ15463.1; -; Genomic_DNA.
DR RefSeq; WP_013406531.1; NC_014654.1.
DR AlphaFoldDB; E4RJP3; -.
DR STRING; 656519.Halsa_2046; -.
DR KEGG; has:Halsa_2046; -.
DR eggNOG; COG0473; Bacteria.
DR HOGENOM; CLU_031953_0_1_9; -.
DR OrthoDB; 9806254at2; -.
DR Proteomes; UP000007434; Chromosome.
DR GO; GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR InterPro; IPR019818; IsoCit/isopropylmalate_DH_CS.
DR InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR PANTHER; PTHR11835; DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE; 1.
DR PANTHER; PTHR11835:SF34; ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00180; Iso_dh; 1.
DR SMART; SM01329; Iso_dh; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR PROSITE; PS00470; IDH_IMDH; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000313|EMBL:ADQ15463.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007434}.
FT DOMAIN 3..331
FT /note="Isopropylmalate dehydrogenase-like"
FT /evidence="ECO:0000259|SMART:SM01329"
SQ SEQUENCE 335 AA; 36114 MW; 3D9A7966DD8DC32C CRC64;
MHNVTMIAGD GIGPEISKAV ADIIAAAGVE INWDKVEAGA GVMDKYGTPL PEQVFDSIRK
NKVALKGPIT TPVGSGFRSV NVAIRKELNL YANVRPLKVH AKAFAQNEAI DMVVFRENTE
GLYVGIEHYV GDEAAESIKI ITRKASRRIV RAAFEYAVRE GRKKVTAVHK ANILKYSDGL
FLEEARNIAA EYAETHPEIE FDDRIVDNMC MQMVQYPEQY DVLVMPNLYG DIVSDLGAGL
IGGLGLAPGM NLGDDIAVFE AVHGSAPDIA GQNKANPVAL LFSAVLMLRH LNEKSAADRI
EKAVSDVLNA GDVLTVDLGG NATTDQITEA IIANL
//
