ID   E4RKD6_HALHG            Unreviewed;      1248 AA.
AC   E4RKD6;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   RecName: Full=DUF445 family protein {ECO:0008006|Google:ProtNLM};
GN   OrderedLocusNames=Halsa_2241 {ECO:0000313|EMBL:ADQ15649.1};
OS   Halanaerobium hydrogeniformans (Halanaerobium sp. (strain sapolanicus)).
OC   Bacteria; Bacillota; Clostridia; Halanaerobiales; Halanaerobiaceae;
OC   Halanaerobium.
OX   NCBI_TaxID=656519 {ECO:0000313|EMBL:ADQ15649.1, ECO:0000313|Proteomes:UP000007434};
RN   [1] {ECO:0000313|EMBL:ADQ15649.1, ECO:0000313|Proteomes:UP000007434}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=sapolanicus {ECO:0000313|Proteomes:UP000007434};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M.,
RA   Hauser L., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N.,
RA   Begemann M.B., Mormile M.R., Wall J.D., Elias D.A., Woyke T.;
RT   "Complete sequence of Halanaerobium sp. sapolanicus.";
RL   Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADQ15649.1, ECO:0000313|Proteomes:UP000007434}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=sapolanicus {ECO:0000313|Proteomes:UP000007434};
RX   PubMed=21602336; DOI=10.1128/JB.05209-11;
RA   Brown S.D., Begemann M.B., Mormile M.R., Wall J.D., Han C.S., Goodwin L.A.,
RA   Pitluck S., Land M.L., Hauser L.J., Elias D.A.;
RT   "Complete Genome Sequence of the Haloalkaliphilic, Hydrogen Producing
RT   Halanaerobium hydrogenoformans.";
RL   J. Bacteriol. 193:3682-3683(2011).
CC   -!- SIMILARITY: Belongs to the UPF0754 family.
CC       {ECO:0000256|ARBA:ARBA00008053}.
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DR   EMBL; CP002304; ADQ15649.1; -; Genomic_DNA.
DR   RefSeq; WP_013406715.1; NC_014654.1.
DR   AlphaFoldDB; E4RKD6; -.
DR   STRING; 656519.Halsa_2241; -.
DR   KEGG; has:Halsa_2241; -.
DR   eggNOG; COG4399; Bacteria.
DR   HOGENOM; CLU_253894_0_0_9; -.
DR   OrthoDB; 9787430at2; -.
DR   Proteomes; UP000007434; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR007383; DUF445.
DR   PANTHER; PTHR35791; UPF0754 MEMBRANE PROTEIN YHEB; 1.
DR   PANTHER; PTHR35791:SF1; UPF0754 THYLAKOID MEMBRANE PROTEIN SLL0412; 1.
DR   Pfam; PF04286; DUF445; 2.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007434};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        621..639
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        659..678
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   1248 AA;  144252 MW;  6A4B5859F7031A92 CRC64;
     MLLDIPAILA AASTGAVTGY LTNNLALKMI FKKYGPFGGV VIKTRDEFIK SISQLVERDI
     INHDTLKEEF SKAEFKKNLN KTVKDLLKFH LYQRSNQEKL SDFPAWKNNY QLSTKYLAEK
     LPQYFISLTS ELAQNHQIDD LLSQEGLNEI IENFYFDFIQ EIKDKNLLKK VLINIYQELK
     EEKISDLLTK QSKAELSDFL KAFSLELNRA YASDQDKADL KQSLKSLVDL NKLSNNLIKK
     IKKIKIEEIF KEERSLENFF TENKFKNIIN EFIINLKIEI EKSELIIDDL ISPQLEKSLK
     EDLDIIIVHS KAKIIKFIRN HENEIEEMIF TAVEEEIKLN SGFKAMSRSA IYNKYQENMD
     EYGSPTELII NYINNSISKD NSLSEKLIRE IKNKKLSQFS SFIKVNSITE KIENYFFSFL
     QENNTKSLEE IFSQDFFENQ NLESKLFNLL FTFIQNTLSD PELLKLFIEN IFGLPLEKVI
     KAEDFSLKAD YLENLILENL KNNYEFINSL FKYINENALI YLNKFIKNNT EIISGQLENR
     FLDLESKIEN KELRDLYKDF SKDKKNILKL TDELCAFLYN YLPEIVEGSI AQTASANLNQ
     LSDQEVQKAI EEFMGKELKP ITYLGALLGA AAGMIFNLTG VEAALMAASP VWVDYVSSAV
     LYGGVGWLTN VLAIWMIFNP YQEKYIASFK MPFTPGVVAK NRNRFADSMG SFVEKELLKA
     NSAAELLENN RAKITDKGLQ YFKEQDYRLL FSLLKNKDSL IAEQLINFSL EQIPKAKGNA
     DLQKYINTKL ANVLENEIKI ISLEEKSLEF LNKKEENINF STAQIGQDIF SLEKVSTALA
     GEYTLSLSSH RFKEIISDKK IFPFAKYLVP QLFGTDLKLD LNDLIFSYLQ ENKDDLFGTA
     TEFLYKEEEN ILQKLKFKKD ELIEFEKAKK GGILKNTLIS GAILMADLDG FIDAVGKRIF
     NHYLPAFFAE EDENIKNDLE SYLKDLEQKS FESLSSFDFS SSATYFFNSA KGEDFLNTFI
     FLNETEIEKL SQALLKGEEK ELFNFNFEVN KIELEKFIKN QFSLEQKLKL LVDLKNIFSD
     QKIKNQFKYL INNNQFVKAE KTWLNFTENL NFAERNFISS QSINEIIDNL SAILEKEETL
     ESIAEETIAL VSDFISHLQK EMDRESLNYL LELFLQSGID SLIVNSEKIV ESLELKELTS
     AEIRKMDPAE IESTFNSFAG HYFNQLKQYG WFGGIFGVLQ LLLRSFIL
//