ID E4RM55_HALHG Unreviewed; 285 AA.
AC E4RM55;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE SubName: Full=Methylenetetrahydrofolate dehydrogenase (NADP(+)) {ECO:0000313|EMBL:ADQ14386.1};
DE EC=1.5.1.5 {ECO:0000313|EMBL:ADQ14386.1};
GN OrderedLocusNames=Halsa_0940 {ECO:0000313|EMBL:ADQ14386.1};
OS Halanaerobium hydrogeniformans (Halanaerobium sp. (strain sapolanicus)).
OC Bacteria; Bacillota; Clostridia; Halanaerobiales; Halanaerobiaceae;
OC Halanaerobium.
OX NCBI_TaxID=656519 {ECO:0000313|EMBL:ADQ14386.1, ECO:0000313|Proteomes:UP000007434};
RN [1] {ECO:0000313|EMBL:ADQ14386.1, ECO:0000313|Proteomes:UP000007434}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=sapolanicus {ECO:0000313|Proteomes:UP000007434};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M.,
RA Hauser L., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N.,
RA Begemann M.B., Mormile M.R., Wall J.D., Elias D.A., Woyke T.;
RT "Complete sequence of Halanaerobium sp. sapolanicus.";
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADQ14386.1, ECO:0000313|Proteomes:UP000007434}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=sapolanicus {ECO:0000313|Proteomes:UP000007434};
RX PubMed=21602336; DOI=10.1128/JB.05209-11;
RA Brown S.D., Begemann M.B., Mormile M.R., Wall J.D., Han C.S., Goodwin L.A.,
RA Pitluck S., Land M.L., Hauser L.J., Elias D.A.;
RT "Complete Genome Sequence of the Haloalkaliphilic, Hydrogen Producing
RT Halanaerobium hydrogenoformans.";
RL J. Bacteriol. 193:3682-3683(2011).
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DR EMBL; CP002304; ADQ14386.1; -; Genomic_DNA.
DR RefSeq; WP_013405476.1; NC_014654.1.
DR AlphaFoldDB; E4RM55; -.
DR STRING; 656519.Halsa_0940; -.
DR KEGG; has:Halsa_0940; -.
DR eggNOG; COG0373; Bacteria.
DR HOGENOM; CLU_059363_0_0_9; -.
DR OrthoDB; 6180at2; -.
DR Proteomes; UP000007434; Chromosome.
DR GO; GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.10280; Methylene-tetrahydromethanopterin dehydrogenase, N-terminal domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR015259; Methyl-teptahyd_DH_N.
DR InterPro; IPR037089; Methyl-teptahyd_DH_N_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR Pfam; PF09176; Mpt_N; 1.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:ADQ14386.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007434}.
FT DOMAIN 17..96
FT /note="Methylene-tetrahydromethanopterin dehydrogenase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF09176"
SQ SEQUENCE 285 AA; 30860 MW; D125787BFB53BD66 CRC64;
MKKLLIQLDT DKRVSTFDQV VAYDAGVDNI IAHSGITKEE VEDIIYGAIF TRSAKKLKNT
AVFIGGSDVE AGEEIMKAVK DVFFANYSIS TMLDSNGSNT TAAAAVLKIR EAIDLVNKKV
VILAGTGPVG VRAAALFAKE GASVTITSRK QAKADRKAAN IKEVYGFEDV RGLEANTDQE
FRNAIKDKDI ILSAGPPKIN FLKEDMWKNT EGIKVMADIN AVSPAGIEGI KPQDDGEKLA
DITVFGALGI GGLKMKLHKK AVASLFKDND KFLNALEIYK LYEKI
//
