ID E4RMT2_HALHG Unreviewed; 405 AA.
AC E4RMT2;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=alanine transaminase {ECO:0000256|ARBA:ARBA00026106};
DE EC=2.6.1.2 {ECO:0000256|ARBA:ARBA00026106};
GN OrderedLocusNames=Halsa_0698 {ECO:0000313|EMBL:ADQ14149.1};
OS Halanaerobium hydrogeniformans (Halanaerobium sp. (strain sapolanicus)).
OC Bacteria; Bacillota; Clostridia; Halanaerobiales; Halanaerobiaceae;
OC Halanaerobium.
OX NCBI_TaxID=656519 {ECO:0000313|EMBL:ADQ14149.1, ECO:0000313|Proteomes:UP000007434};
RN [1] {ECO:0000313|EMBL:ADQ14149.1, ECO:0000313|Proteomes:UP000007434}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=sapolanicus {ECO:0000313|Proteomes:UP000007434};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M.,
RA Hauser L., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N.,
RA Begemann M.B., Mormile M.R., Wall J.D., Elias D.A., Woyke T.;
RT "Complete sequence of Halanaerobium sp. sapolanicus.";
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADQ14149.1, ECO:0000313|Proteomes:UP000007434}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=sapolanicus {ECO:0000313|Proteomes:UP000007434};
RX PubMed=21602336; DOI=10.1128/JB.05209-11;
RA Brown S.D., Begemann M.B., Mormile M.R., Wall J.D., Han C.S., Goodwin L.A.,
RA Pitluck S., Land M.L., Hauser L.J., Elias D.A.;
RT "Complete Genome Sequence of the Haloalkaliphilic, Hydrogen Producing
RT Halanaerobium hydrogenoformans.";
RL J. Bacteriol. 193:3682-3683(2011).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- SIMILARITY: Belongs to the class-I pyridoxal-phosphate-dependent
CC aminotransferase family. {ECO:0000256|ARBA:ARBA00007441}.
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DR EMBL; CP002304; ADQ14149.1; -; Genomic_DNA.
DR RefSeq; WP_013405241.1; NC_014654.1.
DR AlphaFoldDB; E4RMT2; -.
DR STRING; 656519.Halsa_0698; -.
DR KEGG; has:Halsa_0698; -.
DR eggNOG; COG0436; Bacteria.
DR HOGENOM; CLU_017584_4_2_9; -.
DR OrthoDB; 9802328at2; -.
DR Proteomes; UP000007434; Chromosome.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd00609; AAT_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR43488; GLUTAMATE-PYRUVATE AMINOTRANSFERASE ALAA; 1.
DR PANTHER; PTHR43488:SF2; GLUTAMATE-PYRUVATE AMINOTRANSFERASE ALAA; 1.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Aminotransferase {ECO:0000313|EMBL:ADQ14149.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007434};
KW Transferase {ECO:0000313|EMBL:ADQ14149.1}.
FT DOMAIN 62..395
FT /note="Aminotransferase class I/classII"
FT /evidence="ECO:0000259|Pfam:PF00155"
SQ SEQUENCE 405 AA; 45625 MW; 69019843B7FE676D CRC64;
MDYIKKSQKL QNVCYDIRGP VLEEATRLEE EGYNIYKLNI GNTAPFGLDA PDEIIHDVMY
NLKNAQGYCN AHGIFPARKA VMQYYQNKGI LDVEMDDIFI GNGVSELIVM AMQGLLNDGD
EILVPTPDYP LWTAAVNLSG GKAVHYLCDE EAKWYPDLDD IRNKVNEKTK GIVIINPNNP
TGANYPPDIL QGIINIAREN DLIIYSDEIY EKIIYNGTEH TSVATMTDEV LVVTFSGLSK
SHRVPGFRAG WMMLSGQKYH AKSYIEGLNM LASMRLCSNV PSQYAIQTSL GGYQSIEDLV
LPGGRLKEQR DLAYDLLTDI PGLSCVKPEA GLYLFPKIDT ERFNIKNDEK FILDFLTQEK
VLLVQGSGFN WPKPDHFRIV FLPAEEDLRI ALGRLKKFLS NYSQS
//
