ID E4RNW3_HALHG Unreviewed; 320 AA.
AC E4RNW3;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Pyruvate dehydrogenase (Acetyl-transferring) {ECO:0000313|EMBL:ADQ13653.1};
DE EC=1.2.4.1 {ECO:0000313|EMBL:ADQ13653.1};
GN OrderedLocusNames=Halsa_0164 {ECO:0000313|EMBL:ADQ13653.1};
OS Halanaerobium hydrogeniformans (Halanaerobium sp. (strain sapolanicus)).
OC Bacteria; Bacillota; Clostridia; Halanaerobiales; Halanaerobiaceae;
OC Halanaerobium.
OX NCBI_TaxID=656519 {ECO:0000313|EMBL:ADQ13653.1, ECO:0000313|Proteomes:UP000007434};
RN [1] {ECO:0000313|EMBL:ADQ13653.1, ECO:0000313|Proteomes:UP000007434}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=sapolanicus {ECO:0000313|Proteomes:UP000007434};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M.,
RA Hauser L., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N.,
RA Begemann M.B., Mormile M.R., Wall J.D., Elias D.A., Woyke T.;
RT "Complete sequence of Halanaerobium sp. sapolanicus.";
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADQ13653.1, ECO:0000313|Proteomes:UP000007434}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=sapolanicus {ECO:0000313|Proteomes:UP000007434};
RX PubMed=21602336; DOI=10.1128/JB.05209-11;
RA Brown S.D., Begemann M.B., Mormile M.R., Wall J.D., Han C.S., Goodwin L.A.,
RA Pitluck S., Land M.L., Hauser L.J., Elias D.A.;
RT "Complete Genome Sequence of the Haloalkaliphilic, Hydrogen Producing
RT Halanaerobium hydrogenoformans.";
RL J. Bacteriol. 193:3682-3683(2011).
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR EMBL; CP002304; ADQ13653.1; -; Genomic_DNA.
DR AlphaFoldDB; E4RNW3; -.
DR STRING; 656519.Halsa_0164; -.
DR KEGG; has:Halsa_0164; -.
DR eggNOG; COG1071; Bacteria.
DR HOGENOM; CLU_029393_5_0_9; -.
DR Proteomes; UP000007434; Chromosome.
DR GO; GO:0004739; F:pyruvate dehydrogenase (acetyl-transferring) activity; IEA:UniProtKB-EC.
DR CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR029061; THDP-binding.
DR PANTHER; PTHR11516:SF60; PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA; 1.
DR PANTHER; PTHR11516; PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR; 1.
DR Pfam; PF00676; E1_dh; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:ADQ13653.1}; Pyruvate {ECO:0000313|EMBL:ADQ13653.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007434}.
FT DOMAIN 14..310
FT /note="Dehydrogenase E1 component"
FT /evidence="ECO:0000259|Pfam:PF00676"
FT COILED 277..304
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 320 AA; 34659 MW; 9979E4A8C167E2D0 CRC64;
MEKSKETLLD MYEKMYKIRL FEDNAVKLFN QGLVRGPMHV YTGEEAVAVG ACSNLNDDDL
ITSTHRGHGH CIAKGGRVDK MAAELLAKGT GYCKGKGGSM HIADPDIGIL GANGIVGAGL
PIATGSALSS KMRGTDQVTI CFFGDGATNE GAFHEALNMA AIWDLPVVFV CENNLYGLTG
PADEMVSVKD VASRAASYDI PGVVVDGNDV LDVYETVGEA IKRAKNGGGP SLIEAKTYRI
KGHFVGDPQV YRDDEEVEKW KKRCPIKKHR NYLIETVGVA SEELAEIEAK VKKEIKEAVK
FAKESPDPEI EVVFEDVFSK
//
