ID E4U4K9_OCEP5 Unreviewed; 618 AA.
AC E4U4K9;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Peptidase S8 and S53 subtilisin kexin sedolisin {ECO:0000313|EMBL:ADR37002.1};
DE Flags: Precursor;
GN OrderedLocusNames=Ocepr_1549 {ECO:0000313|EMBL:ADR37002.1};
OS Oceanithermus profundus (strain DSM 14977 / NBRC 100410 / VKM B-2274 /
OS 506).
OC Bacteria; Deinococcota; Deinococci; Thermales; Thermaceae; Oceanithermus.
OX NCBI_TaxID=670487 {ECO:0000313|EMBL:ADR37002.1, ECO:0000313|Proteomes:UP000008722};
RN [1] {ECO:0000313|Proteomes:UP000008722}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14977 / NBRC 100410 / VKM B-2274 / 506
RC {ECO:0000313|Proteomes:UP000008722};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S.,
RA Kyrpides N., Mavromatis K., Pagani I., Ivanova N., Zhang X., Brettin T.,
RA Detter J.C., Tapia R., Han C., Land M., Hauser L., Markowitz V.,
RA Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Tindall B., Faehnrich R.,
RA Brambilla E., Klenk H.-P., Eisen J.A.;
RT "The complete sequence of chromosome of Oceanithermus profundus DSM
RT 14977.";
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADR37002.1, ECO:0000313|Proteomes:UP000008722}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14977 / NBRC 100410 / VKM B-2274 / 506
RC {ECO:0000313|Proteomes:UP000008722};
RX PubMed=21677858; DOI=10.4056/sigs.1734292;
RA Pati A., Zhang X., Lapidus A., Nolan M., Lucas S., Del Rio T.G., Tice H.,
RA Cheng J.F., Tapia R., Han C., Goodwin L., Pitluck S., Liolios K.,
RA Pagani I., Ivanova N., Mavromatis K., Chen A., Palaniappan K., Hauser L.,
RA Jeffries C.D., Brambilla E.M., Rohl A., Mwirichia R., Rohde M.,
RA Tindall B.J., Sikorski J., Wirth R., Goker M., Woyke T., Detter J.C.,
RA Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C.,
RA Klenk H.P., Land M.;
RT "Complete genome sequence of Oceanithermus profundus type strain (506).";
RL Stand. Genomic Sci. 4:210-220(2011).
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC ECO:0000256|RuleBase:RU003355}.
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DR EMBL; CP002361; ADR37002.1; -; Genomic_DNA.
DR RefSeq; WP_013458172.1; NC_014761.1.
DR AlphaFoldDB; E4U4K9; -.
DR STRING; 670487.Ocepr_1549; -.
DR KEGG; opr:Ocepr_1549; -.
DR eggNOG; COG1404; Bacteria.
DR HOGENOM; CLU_417860_0_0_0; -.
DR OrthoDB; 9798386at2; -.
DR Proteomes; UP000008722; Chromosome.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000008722};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..618
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003190222"
FT DOMAIN 224..531
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT REGION 256..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 231
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 276
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 483
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 618 AA; 65291 MW; E2524DE1BF225A29 CRC64;
MRRLAAVLLP ALLAACSSGL PEAPRDLTLN FDGRGTLNLP VPDGTIWRIQ GPEGLRVEPA
QGIGPAVLAL EAPLERAPNL PAERFTLEWR GDLQGTLTVR WPLVRVEGRV VEPPAARAGL
DLPARPLPEP APAPAPTRVL VRYRDAGAAP LGAKSAGTPT LRVLETADAA ALLARLQSDP
NVVWAEPDGT VRALGEPSDE YYPLEWHLRR TGARWAYLDG YPRSVTVAVI DTGVRYDHPD
LTDRLWGPAD GAYDFVEGDP DPTDPGDNRN PQAGSHGTHV TGIIAARTGV NPLPPACYDP
NGDPICSETG LAGLAWPADV KVLPLRVLDE TGNGSFSAVA AAIRYAAGLP VEWEGQTLSN
PHPAQVINLS LGATLFSNAM CEAVADARAA GALVVAAAGN SGGTAYFYPA SCPGALSVAA
VDNAAGEPRP TWYSQHNDRV ALSAPGGDVQ QDADGDGYPD GVLSTTWNFQ TQRPNYAFYM
GTSQASPQVA AALALLLAQD PGRSTEAALE RLTATATDLG PPGRDAYYGY GFLNLPQALA
LELPPGPYRV RFRGPFERWV TPDADGNFAV YLPSAPYAVV ACRDDTANGF CDRGEPRTEA
SVQVAPEPLF RMPALTLP
//