ID E4UN52_ARTGP Unreviewed; 329 AA.
AC E4UN52;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Radical S-adenosyl methionine domain-containing protein 2 {ECO:0000313|EMBL:EFR00354.1};
GN ORFNames=MGYG_03356 {ECO:0000313|EMBL:EFR00354.1};
OS Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum
OS gypseum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Nannizzia.
OX NCBI_TaxID=535722 {ECO:0000313|Proteomes:UP000002669};
RN [1] {ECO:0000313|Proteomes:UP000002669}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4604 / CBS 118893 {ECO:0000313|Proteomes:UP000002669};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; DS989823; EFR00354.1; -; Genomic_DNA.
DR RefSeq; XP_003175836.1; XM_003175788.1.
DR AlphaFoldDB; E4UN52; -.
DR STRING; 535722.E4UN52; -.
DR GeneID; 10031146; -.
DR VEuPathDB; FungiDB:MGYG_03356; -.
DR eggNOG; ENOG502QQMH; Eukaryota.
DR HOGENOM; CLU_049058_1_0_1; -.
DR InParanoid; E4UN52; -.
DR OMA; ERWFKKY; -.
DR OrthoDB; 3671494at2759; -.
DR Proteomes; UP000002669; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR007197; rSAM.
DR NCBIfam; NF038283; viperin_w_prok; 1.
DR PANTHER; PTHR21339; RADICAL S-ADENOSYL METHIONINE DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR21339:SF0; RADICAL S-ADENOSYL METHIONINE DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF13353; Fer4_12; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SFLD; SFLDG01067; SPASM/twitch_domain_containing; 1.
DR SFLD; SFLDF00318; Viperin; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002669};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT DOMAIN 34..249
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 329 AA; 38048 MW; E78BCA7433524218 CRC64;
MPPFKSIPGY HIPCNYHFHR SMHVHFTVAT TGTQKPPVSV NYHFTRQCNK SCGFCFHTAT
TSFKLSISNA KKGLHKLKHA GMRKINFAGG EPFMYPKLLG PMVQFCKEEL NLESVSIVTN
GSLVKRDFLE KYGRFIDILA VSCDSFNEQT NIDIGRGKGD QVPQLFRIAQ WCKEYGIKFK
LNTVVCNLNH QEDMNSVVEK LQPFRWKCFQ VLMVQGENDS DKTMRDVRKF QITDQQYEEF
CRRHEHQPSF VAEPNNLMAK SYLILDEYMR FLDRDGRGPS AFILDVGVFT ALGQVYWDET
SFKKRGGIYN WSREKNEPSC GSNDKALEW
//
