ID E4UNI1_ARTGP Unreviewed; 451 AA.
AC E4UNI1;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=2-hydroxy-3-oxopropionate reductase {ECO:0000313|EMBL:EFQ99589.1};
GN ORFNames=MGYG_02602 {ECO:0000313|EMBL:EFQ99589.1};
OS Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum
OS gypseum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Nannizzia.
OX NCBI_TaxID=535722 {ECO:0000313|Proteomes:UP000002669};
RN [1] {ECO:0000313|Proteomes:UP000002669}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4604 / CBS 118893 {ECO:0000313|Proteomes:UP000002669};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
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DR EMBL; DS989823; EFQ99589.1; -; Genomic_DNA.
DR RefSeq; XP_003175072.1; XM_003175024.1.
DR AlphaFoldDB; E4UNI1; -.
DR STRING; 535722.E4UNI1; -.
DR GeneID; 10030377; -.
DR VEuPathDB; FungiDB:MGYG_02602; -.
DR eggNOG; KOG0409; Eukaryota.
DR HOGENOM; CLU_035117_1_2_1; -.
DR InParanoid; E4UNI1; -.
DR OMA; QMFMQAS; -.
DR OrthoDB; 1121581at2759; -.
DR Proteomes; UP000002669; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 2.
DR Pfam; PF03446; NAD_binding_2; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002669}.
FT DOMAIN 8..167
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 177..298
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT DOMAIN 320..439
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
SQ SEQUENCE 451 AA; 47851 MW; CB070DCC56C91508 CRC64;
MAITPKPTVG FVGLGAMGFG MAVHLITQGY SVKGFDTWAP ALERFREAGG NVAASLEDSA
KGCMYYVCMV ASAPQVQSIL FDDAKPILKA LPFGATFILC STVPAAYAQS VRDQLASSGR
GDISFIDAPV SGGAIRAANG TLSIMAGGSD TALERGRFLL AEMSDAAKLY LVPGGVGAGS
NMKMVHQVLA GIHILAASEA MGFAARLGLD AQEVCNAIVA SDAWSWMHEN RSPRMLKEDY
FPGVSALTII LKDVTIITKS ARLHQFPVPL SSTAEQIYVA GLSPGYGADD DAGMVRMYYP
EPISKVKSPT TMTPEFKSKA TNLVISLLRH IHLCAAAEAI AFARFLSLDM AQFYELVNAA
AGGSFIFKSK AMEMINSANQ AGTSAVKILN EAVDELSDVV QEARNVDCPL HLGAAALGIL
HQAKFRGWGK DSDSSVIRLW ETHNEHCSNS S
//
