ID E4UNX2_ARTGP Unreviewed; 656 AA.
AC E4UNX2;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=histone deacetylase {ECO:0000256|ARBA:ARBA00012111};
DE EC=3.5.1.98 {ECO:0000256|ARBA:ARBA00012111};
GN ORFNames=MGYG_02739 {ECO:0000313|EMBL:EFQ99725.1};
OS Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum
OS gypseum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Nannizzia.
OX NCBI_TaxID=535722 {ECO:0000313|Proteomes:UP000002669};
RN [1] {ECO:0000313|Proteomes:UP000002669}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4604 / CBS 118893 {ECO:0000313|Proteomes:UP000002669};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- SIMILARITY: Belongs to the histone deacetylase family. HD type 1
CC subfamily. {ECO:0000256|ARBA:ARBA00006457}.
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DR EMBL; DS989823; EFQ99725.1; -; Genomic_DNA.
DR RefSeq; XP_003175208.1; XM_003175160.1.
DR AlphaFoldDB; E4UNX2; -.
DR STRING; 535722.E4UNX2; -.
DR GeneID; 10030514; -.
DR VEuPathDB; FungiDB:MGYG_02739; -.
DR eggNOG; KOG1342; Eukaryota.
DR HOGENOM; CLU_007727_0_3_1; -.
DR InParanoid; E4UNX2; -.
DR OMA; EHRWDKH; -.
DR OrthoDB; 1327607at2759; -.
DR Proteomes; UP000002669; Unassembled WGS sequence.
DR GO; GO:1902494; C:catalytic complex; IEA:UniProt.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0004407; F:histone deacetylase activity; IEA:UniProtKB-EC.
DR GO; GO:0010468; P:regulation of gene expression; IEA:UniProt.
DR CDD; cd10004; RPD3-like; 1.
DR Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR InterPro; IPR000286; His_deacetylse.
DR InterPro; IPR003084; His_deacetylse_1.
DR InterPro; IPR023801; His_deacetylse_dom.
DR InterPro; IPR037138; His_deacetylse_dom_sf.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR PANTHER; PTHR10625:SF13; HISTONE DEACETYLASE HDAC1; 1.
DR PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR Pfam; PF00850; Hist_deacetyl; 1.
DR PRINTS; PR01270; HDASUPER.
DR PRINTS; PR01271; HISDACETLASE.
DR SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Reference proteome {ECO:0000313|Proteomes:UP000002669}.
FT DOMAIN 38..327
FT /note="Histone deacetylase"
FT /evidence="ECO:0000259|Pfam:PF00850"
FT REGION 435..656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..469
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..591
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 636..656
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 656 AA; 73256 MW; 217A68D0723E0157 CRC64;
MTGFAPLDAP VTNGSTDKKR IAYFYDSDVG NYAYVAGHPM KPHRIRMTHS LVMNYGLYKK
MEIYRAKPAS KFEMTQFHTD EYIDFLAKVT PDNMDQYAKE QSRYNVGDDC PVFDGLFEFC
GISAGGSMEG AARLNRNKCD IAVNWAGGLH HAKKSEASGF CYVNDIVLGI LELLRFKQRV
LYIDIDVHHG DGVEEAFYTT DRVMTVSFHK YGEYFPGTGE LRDIGVGAGK YYAVNFPLRD
GIDDVSYKGI FEPVIKHVME WYRPEAVVLQ CGGDSLSGDR LGCFNLSMRG HANCVKYVKS
FNLPTLILGG GGYTMRNVAR TWAYETGVLV GNQLPTELPY NDYYEYFSPD YELDVRPSNM
DNANSKEYLE KIRMQVVENL RRTTFAPSVQ MTDVPRDPLV DGMDDEADAI LDDLDEDENK
DKRYTKRRFD NYVEKDGELS ESEDEESAAA NGVRRQPNRE RRRGNINYRH LDGDSIIDSG
IVTPRDESSM PEEEPEQADK MDEGENTEAP AKPSPPAIEP STKPDTQMAD DEAPVADTNG
TAPEAEEKEP AVSTPASNLE VPQENIDGDT TMEDADVNMD ETLELEPPAE EQDEAPVTKS
PARETTPPKS PAPEETKPSV PEPESIATEP TQTADTTEAK ESKPDTDAAN ETPKEK
//