ID E4USV3_ARTGP Unreviewed; 1094 AA.
AC E4USV3;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=ATP-dependent helicase NAM7 {ECO:0000313|EMBL:EFR01402.1};
GN ORFNames=MGYG_04409 {ECO:0000313|EMBL:EFR01402.1};
OS Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum
OS gypseum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Nannizzia.
OX NCBI_TaxID=535722 {ECO:0000313|Proteomes:UP000002669};
RN [1] {ECO:0000313|Proteomes:UP000002669}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4604 / CBS 118893 {ECO:0000313|Proteomes:UP000002669};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC {ECO:0000256|ARBA:ARBA00007913}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01341}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS989824; EFR01402.1; -; Genomic_DNA.
DR RefSeq; XP_003174232.1; XM_003174184.1.
DR AlphaFoldDB; E4USV3; -.
DR STRING; 535722.E4USV3; -.
DR GeneID; 10029522; -.
DR VEuPathDB; FungiDB:MGYG_04409; -.
DR eggNOG; KOG1802; Eukaryota.
DR HOGENOM; CLU_001666_4_0_1; -.
DR InParanoid; E4USV3; -.
DR OMA; VRSNDNQ; -.
DR OrthoDB; 170190at2759; -.
DR Proteomes; UP000002669; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR CDD; cd21407; 1B_UPF1-like; 1.
DR CDD; cd18039; DEXXQc_UPF1; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR CDD; cd21400; ZBD_UPF1-like; 1.
DR Gene3D; 2.40.30.230; -; 1.
DR Gene3D; 6.10.140.1240; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR040812; UPF1_1B_dom.
DR InterPro; IPR018999; UPF1_CH/ZBD.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF364; REGULATOR OF NONSENSE TRANSCRIPTS 1; 1.
DR Pfam; PF13086; AAA_11; 2.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF18141; UPF1_1B_dom; 1.
DR Pfam; PF09416; UPF1_Zn_bind; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51997; UPF1_CH_RICH; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000313|EMBL:EFR01402.1};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Helicase {ECO:0000313|EMBL:EFR01402.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU01341}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002669};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU01341};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01341}.
FT DOMAIN 84..236
FT /note="Upf1"
FT /evidence="ECO:0000259|PROSITE:PS51997"
FT REGION 21..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 101..129
FT /note="CC/SHH/C"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 147..177
FT /note="C4"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 958..1002
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1020..1094
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 988..1002
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1094 AA; 119927 MW; 136940C4B8DFE6FF CRC64;
MEAFTKMGNH MVSDSAATIN ASGDDISTAD GDESVLNMAG GPQKRRHDDE DEGSDTLDDD
DDDDLESMAS VAIGGAGKTQ ASKTEEEKEL PAHACGSVVK CLTCNKWFCS ARGNTSSSHI
VNHLVRARHK EVQLHPASSL GDTILECYNC GTKNVFLLGF IPAKSDTVVV LLCRQPCAAM
PSSKDMNWDT SRWQPLMEDR SFLPWLVSAP SDQEQLRARH LSPQMIAKLE ELWKENASAT
VEDLEKATNV DDEPAPVLLR YDDAYQYQNV FGPLVKIEAD YDRKLKEAQS QDGLTVRWDL
GLNNKHLASF VLPKLELGDV KLAVGDEMRL KYAGELRPKW EGVGYVIKIP NNQSDEVTIE
LRSKGDHKSV PTEISHNFTA DYVWKATSFD RMQLAMKTFA VDEMSVSGYI FHRLLGNEVA
AAPMKTQMPK QFSVPGLPGL NSSQINAVKA VLQKPLSLIQ GPPGTGKTVT SATIIYHLAK
VNAGQVLVCA PSNVAVDQLC ECIHRTGLKT VRVTAKSRED VESPVRHLSL HEQVRNNDSN
IELVKLNQLK TELGELSSQD EKKYKQLTRA AEKEILTNAD VICCTCVGAG DPRLAKSKFR
TVLIDESTQS AEPECMIPLV LGCKQAVLVG DHQQLGPVIM NKKAAKAGLN QSLFERLVIL
GCAPIRLNVQ YRMHPCLSQF SSNMFYEGSL QNGVSSEDRL LKNVDFPWPV ADKPMMFWSN
LGNEEISASG TSYLNRTEAA NVEKIVTRFF KAGVKPSGIG IITPYEGQRS YVVSSMQLTG
TFKKEWYKEI EVASVDAFQG REKDFIVLSC VRSNDHQGIG FLSDPRRLNV ALTRAKYGLV
ILGNPKVLSK HPLWNYLLRH FKEQNCLVEG PLSNLQTSLI QFSRPKQAYR GPQRFQMSFN
HASNVDSSML NGRNGHHHDY HDAGSVVSYI PDDVSSVHSS ALGGVAIPSG YPHMFQNFTE
SWPSGPNNRR PNGSRMRGAP SVAGESVAAT ESDVTGSVVD GRSTIGQGGV SLSGLSIHDV
QKQTSLSQSD RLKRYVESSG RPETYRSGTD AGSVFGGSAA GIRVPRQNLG HSGDDDDARS
VSTAFASQVG GNYD
//
