ID E4UT06_ARTGP Unreviewed; 590 AA.
AC E4UT06;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE RecName: Full=Vacuolar protein sorting-associated protein 17 {ECO:0000256|PIRNR:PIRNR011791};
GN ORFNames=MGYG_03625 {ECO:0000313|EMBL:EFR00619.1};
OS Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum
OS gypseum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Nannizzia.
OX NCBI_TaxID=535722 {ECO:0000313|Proteomes:UP000002669};
RN [1] {ECO:0000313|Proteomes:UP000002669}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4604 / CBS 118893 {ECO:0000313|Proteomes:UP000002669};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- FUNCTION: Component of the membrane-associated retromer complex which
CC is essential in endosome-to-Golgi retrograde transport.
CC {ECO:0000256|PIRNR:PIRNR011791}.
CC -!- SUBUNIT: Component of the retromer complex.
CC {ECO:0000256|PIRNR:PIRNR011791}.
CC -!- SIMILARITY: Belongs to the VPS17 family.
CC {ECO:0000256|PIRNR:PIRNR011791}.
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DR EMBL; DS989824; EFR00619.1; -; Genomic_DNA.
DR RefSeq; XP_003173449.1; XM_003173401.1.
DR AlphaFoldDB; E4UT06; -.
DR STRING; 535722.E4UT06; -.
DR GeneID; 10028728; -.
DR VEuPathDB; FungiDB:MGYG_03625; -.
DR eggNOG; KOG2273; Eukaryota.
DR HOGENOM; CLU_028982_0_0_1; -.
DR InParanoid; E4UT06; -.
DR OMA; FYLGTME; -.
DR OrthoDB; 1708746at2759; -.
DR Proteomes; UP000002669; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0030904; C:retromer complex; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR CDD; cd06891; PX_Vps17p; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR014461; Retromer_complex_Vps17.
DR InterPro; IPR037907; Vps17_PX.
DR InterPro; IPR015404; Vps5_C.
DR PANTHER; PTHR47433; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17; 1.
DR PANTHER; PTHR47433:SF1; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF09325; Vps5; 1.
DR PIRSF; PIRSF011791; Vps17; 1.
DR SUPFAM; SSF64268; PX domain; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|PIRNR:PIRNR011791};
KW Reference proteome {ECO:0000313|Proteomes:UP000002669};
KW Transport {ECO:0000256|PIRNR:PIRNR011791}.
FT DOMAIN 166..242
FT /note="PX"
FT /evidence="ECO:0000259|Pfam:PF00787"
FT DOMAIN 297..477
FT /note="Sorting nexin/Vps5-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF09325"
FT REGION 1..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 494..527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..69
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 590 AA; 65210 MW; 4FA24085B4546ECE CRC64;
MDYSSISNDP DPTDSSPWGS TSPRAARPFS ASSDVPPAFP SQHQSPYTTD HEGPYHHNGE
GDERVQSPGL SDHPTDSHHV GSPEAQSAYR HDGQPQHQQE YRQQQQQRSQ APSRYQTGAR
QQPRPNAPKY KLQAKVTALE RTGKKDPVIR FDVHTNIPKF RTTQFRDVRR THSEFIKLGD
HLISSNPEAL VPAVPPPLTP AGAGTEEDEM RVKASMQRWL NYVCSNDVLM VDDEMILFVE
SDSGYSPVVR MKQPATGVRR KVIKQFAPPP DDTPELHDAR PVVKLFYLGT MEAGQKVDRV
VKARRALALA ESDLGVKLGQ MHVQETHAGL ANAYKKLGKI IQTTGDYHAA QGTAEATTLG
DPLNYHSSDA FIVKETLTNR HILLRELIQA QQAASSKRAA ADRLKASTSV RPDKVDEAIS
ALDDARGHEE YLLKKTQRVT NNLLQEKRRW FNRTANDLLL SLREYTLREI EAERRTLSTL
ESVRADIRSI DSSGGLSRLG RESHPAARRA SLASSQGPKG DAWSGVARRG DSLSRSISGS
FVAPVPEVDD DVNGSIHGTG RRSRSGTIIE EDDDRVDAKN AASRLAASTF
//
