ID E4UT91_ARTGP Unreviewed; 1805 AA.
AC E4UT91;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Rho1 guanine nucleotide exchange factor 3 {ECO:0000313|EMBL:EFR00652.1};
GN ORFNames=MGYG_03659 {ECO:0000313|EMBL:EFR00652.1};
OS Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum
OS gypseum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Nannizzia.
OX NCBI_TaxID=535722 {ECO:0000313|Proteomes:UP000002669};
RN [1] {ECO:0000313|Proteomes:UP000002669}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4604 / CBS 118893 {ECO:0000313|Proteomes:UP000002669};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
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DR EMBL; DS989824; EFR00652.1; -; Genomic_DNA.
DR RefSeq; XP_003173482.1; XM_003173434.1.
DR STRING; 535722.E4UT91; -.
DR GeneID; 10028761; -.
DR VEuPathDB; FungiDB:MGYG_03659; -.
DR eggNOG; KOG4305; Eukaryota.
DR HOGENOM; CLU_001083_0_0_1; -.
DR InParanoid; E4UT91; -.
DR OMA; DMFYHPG; -.
DR OrthoDB; 2734900at2759; -.
DR Proteomes; UP000002669; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041675; PH_5.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46572:SF1; RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF15405; PH_5; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Reference proteome {ECO:0000313|Proteomes:UP000002669};
KW Transferase {ECO:0000256|ARBA:ARBA00022676}.
FT DOMAIN 974..1166
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1203..1365
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1431..1739
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 1..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 358..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 427..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 523..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 592..611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 739..763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..376
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..441
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..466
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..544
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 596..611
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 739..761
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1805 AA; 199394 MW; 4AFC2B9B54D2AC84 CRC64;
MPDQENRPPR AYPPLSAAVS HGPSQPHVHH GQQGIAPQAP SQQQQHASQY PTGPHLAGQK
PPHAQMQRSP SYQAGDDTGY FDSRAAVGGG ASAYPYHDGR GGSVHGSHSS NFGSRHSQHS
AVSQTSSHGS SAMSGYQHQY QGTSTPSPGQ QQPSYNPQQF SQQQQQQQPP PTPQQASYNP
QAFSQFSSQQ PHHQPYIPAA YQSSPSVGSF QSSPGVNWSA GTPVQTSYPS TSPSFFPPSH
AVPTSPGPMS ARPLDSYNDY SLPYGNQTTH HHPTYPPIAS QSVAATPVSA HPSSYSSYNY
PSSAHPQSAV TYGTEATNDR IRRYSSAKAP AQAAEYQYTP NTPAHSTVQH DAGYWATKPA
SYSASPPPPP PPAHHNSQSS SPRRTDTLTR HPQARPLPGP PPEFEGRNGR DQVEPSYDDI
IKEVEAAVME GRPDTTRRHS SRARRPLPQQ PPIQESDDSP YPTSALSPGV QLFPDEVQTH
TNGGNISSTG TGQYVNYNAY SDDSDAEVAA GLEALRVADE EEAAMRARRN THTSTASSFG
YQHQETPPPP LPQSQHRGES SSDSDFALHD IGLYGGGYSA DMHYGEDALM EGARANSQRE
SRNSTSNQYD YPSIDQDSIH PFPEIEPTAR VDAVGTGGLS EPSAYRRMSF ENGDEAVLRR
HSSATSSLSD APGEGEPQDL FFHPGMSSRP LPPPPVPIAA QNLLPHLMPA GTYRSSEHTG
QIPLDHYHMP GYPTSPNTYT HSNSTSAVPR STSLSDHTTS HKSADAIIRS KTDADRAKSK
QAAYDSSMST PSVTLDLPVL PTGKRKKFHP GKLSSEQFRK CSEPWAISAI VAWIRDLAED
ETDLKEHSIV EAIVALFTHK VPTMNTADAE TLSDRVVKSM FAAGALIKDE EWVKFGPGTL
SGVLWQITGQ GCYSSRLHNQ EYDIFGRCYS HHCMRTLKKI NLKMVEAQKK AEDWATFYKI
GKEVFSSHSK KEIDRQNNLH EIVTTEDSYI AQLDVLRTLY RDTLATAQPS VISPKRLDRF
LRDVFGKVDA VKRVNEEYLL AQLKYRQKEQ GPFIVGFSDI FREWIRKAKA AYIEYAATFP
NANYLVRREA ESNMLFRSFL NQARENRLSN RLSWDTYLKA PITRIQRYTL LLSTVHKNME
KDSEEKANLL QAIEEIKLVA LDCDNKVGEM TKKMDLKELG AKLQLRPEMK SIVELNLEHL
GREIIHQGDL QRPRTKRFNW VDIRAILFDH YLVLAKIVIH RDAAGIKHET FDVSKLPIPM
DLLTLVSTND DPVVRSAVKG IAPANPRVGA PAGLAHAATA PQLNSPAPGA AGRSVTTTVL
ENSRDEKILY PFRIKHLGKR DVYVLYAPTA QSRQEWCEKI FEAKTKHAAA LYAQNAEPFR
LRVLSDSAFA YSDQAVPTKS AVIKGTPLDR AIRDVEKKYE RNLSRPLPVC RAAVNCATVF
QQPPGKMMCA IGTDYGVYIS AYDDPRGWTK GISMLRVTQI SVFEEFNLFL LISDKSLIGY
HLDAICPVNG AVQPDSQRRA PQKLSGNREV GFFAAGRMKD RALVFYKKRD GISSTFKVLE
PVLQKSSSSR SRFLSRRGQT EFFREYDEFY IPAESYGINL FHTSLAISTS RGVEVLTLDK
KQPWSVPNLK SEQADVQSHL TSIANRVKDL RPLGMFRLSD SEFLVAFQEC AVYVNKHGDV
SRSVVMEFVG IAHAACLCGK FLLLFNEDFV EVRNAMNGRL RQVIAGRNVT LLDDGGNNGV
GADHHANAVG GSNFNDTAST HTRNGLGIST GFGGISRTVK ICMQHPERER SQIVLELLEN
EGQKD
//
