ID E4UUA5_ARTGP Unreviewed; 755 AA.
AC E4UUA5;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=CAMKK/META protein kinase {ECO:0000313|EMBL:EFR00872.1};
GN ORFNames=MGYG_03875 {ECO:0000313|EMBL:EFR00872.1};
OS Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum
OS gypseum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Nannizzia.
OX NCBI_TaxID=535722 {ECO:0000313|Proteomes:UP000002669};
RN [1] {ECO:0000313|Proteomes:UP000002669}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4604 / CBS 118893 {ECO:0000313|Proteomes:UP000002669};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
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DR EMBL; DS989824; EFR00872.1; -; Genomic_DNA.
DR RefSeq; XP_003173702.1; XM_003173654.1.
DR AlphaFoldDB; E4UUA5; -.
DR STRING; 535722.E4UUA5; -.
DR GeneID; 10028985; -.
DR VEuPathDB; FungiDB:MGYG_03875; -.
DR eggNOG; KOG0585; Eukaryota.
DR HOGENOM; CLU_000288_165_0_1; -.
DR InParanoid; E4UUA5; -.
DR OMA; FVEPPME; -.
DR OrthoDB; 5489318at2759; -.
DR Proteomes; UP000002669; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd14008; STKc_LKB1_CaMKK; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR24346:SF77; CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE KINASE 1; 1.
DR PANTHER; PTHR24346; MAP/MICROTUBULE AFFINITY-REGULATING KINASE; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000313|EMBL:EFR00872.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000002669};
KW Transferase {ECO:0000313|EMBL:EFR00872.1}.
FT DOMAIN 87..386
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 126..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 481..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 649..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..510
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..529
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 653..677
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 115
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 755 AA; 83013 MW; 458B08C42974C9B2 CRC64;
MDADPILKHG RTAQLALDTE VPTSRSSEPG PNALKGARPA SGSYDSPLRQ HARYPTAPRQ
VKETLNAQST YTNSQDDNTA EHRINQYLIK QEIGRGSFGA VHLATDQYGQ EYAVKEFSKS
RLRKRAQSHG LRRRTGKHPG VQPAGVGFNS PLHRHPSGID EGENGNSLYL IREEIAIMKK
LNHSNLVSLI EVLDDPTEDS LYMVMEMCKK GVIMKVGLGE QADPYSEENC RCWFRDLILG
IEYLHAQGIV HRDIKPDNCL LTNDDVLKVV DFGVSEMFEK SSDMFIAKSA GSPAFIPPEL
CVAKYGEVSG RAVDVWSMGV TLYCLRYGRI PFHTSNIFDL YNAIRNDEVE LPGETNEAFK
DLMKQILEKD PAKRITMPQL RVHPWVTKGG IDPLLSEEEN TATLVGPPTE EEMDSAITRN
LGHALIVVKA VQKFKRLISD GSPLPMESIL GEGEESHFVQ PPLLMGEDEE EEFSAILHNR
NMKEHVYPRR PDQPKRPSQA TMNSSPYVSL PPPNTFEPCA FPSPQPQSTP GADTPTRQTG
SEGTRGHARD PLEEEMPFLN IGPSNFGSEA ELNPTNDTAM ESGGIPIPSK PAVTESPMIV
SESPPAADID IYETAYKEII ERINSRSREA QSPTPKVYLN RRVEKKPTAS SGLWSVARKN
SKLSSPLSRS VTDTVPDNRP PRPSPIKRFT AAAASFAASS GKQSPSPLAK AVQVNDAVRS
DEGIEPNPLD TSAAVIETTA SPTALSPVDD AKKDM
//
