ID E4UXJ3_ARTGP Unreviewed; 628 AA.
AC E4UXJ3;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE RecName: Full=General negative regulator of transcription subunit {ECO:0000256|PIRNR:PIRNR005290};
GN ORFNames=MGYG_05726 {ECO:0000313|EMBL:EFR02727.1};
OS Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum
OS gypseum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Nannizzia.
OX NCBI_TaxID=535722 {ECO:0000313|Proteomes:UP000002669};
RN [1] {ECO:0000313|Proteomes:UP000002669}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4604 / CBS 118893 {ECO:0000313|Proteomes:UP000002669};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- FUNCTION: Acts as component of the CCR4-NOT core complex, which in the
CC nucleus seems to be a general transcription factor, and in the
CC cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT
CC protein subcomplex negatively regulates the basal and activated
CC transcription of many genes. Preferentially affects TC-type TATA
CC element-dependent transcription. Could directly or indirectly inhibit
CC component(s) of the general transcription machinery.
CC {ECO:0000256|PIRNR:PIRNR005290}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR005290}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR005290}.
CC -!- SIMILARITY: Belongs to the CNOT2/3/5 family.
CC {ECO:0000256|ARBA:ARBA00007682, ECO:0000256|PIRNR:PIRNR005290}.
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DR EMBL; DS989825; EFR02727.1; -; Genomic_DNA.
DR RefSeq; XP_003173138.1; XM_003173090.1.
DR AlphaFoldDB; E4UXJ3; -.
DR STRING; 535722.E4UXJ3; -.
DR GeneID; 10028417; -.
DR VEuPathDB; FungiDB:MGYG_05726; -.
DR eggNOG; KOG2150; Eukaryota.
DR HOGENOM; CLU_013819_3_0_1; -.
DR InParanoid; E4UXJ3; -.
DR OMA; YKPQTPY; -.
DR OrthoDB; 10289at2759; -.
DR Proteomes; UP000002669; Unassembled WGS sequence.
DR GO; GO:0030015; C:CCR4-NOT core complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000932; C:P-body; IEA:UniProtKB-UniRule.
DR GO; GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 2.30.30.1020; CCR4-NOT complex subunit 2/3/5, C-terminal domain; 1.
DR InterPro; IPR038635; CCR4-NOT_su2/3/5_C_sf.
DR InterPro; IPR012270; CCR4-NOT_su3/5.
DR InterPro; IPR040168; Not2/3/5.
DR InterPro; IPR007282; NOT2/3/5_C.
DR InterPro; IPR007207; Not_N.
DR PANTHER; PTHR23326; CCR4 NOT-RELATED; 1.
DR PANTHER; PTHR23326:SF1; CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 3; 1.
DR Pfam; PF04153; NOT2_3_5_C; 1.
DR Pfam; PF04065; Not3; 1.
DR PIRSF; PIRSF005290; NOT_su_3_5; 2.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|PIRNR:PIRNR005290};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR005290};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR005290};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002669};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|PIRNR:PIRNR005290};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR005290};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR005290}.
FT DOMAIN 3..231
FT /note="CCR4-Not complex component Not N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04065"
FT DOMAIN 496..624
FT /note="NOT2/NOT3/NOT5 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04153"
FT REGION 234..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 336..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 124..151
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 241..255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..307
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..408
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 416..442
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..457
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 628 AA; 70077 MW; 888348EEB200544F CRC64;
MTSRKTQQEI DKTFKKVSEG IQSFEGIYDK IRSSSNAAQR DKLEDNLKRE IKKLQRFRDQ
IKTWAAGNEV KDKSPLLEQR RAIETCMEQF KAVEKEMKTK AYSKEGLSAA ARLDPKEKEK
ADTCDFLSLT VDILQQKIEA MEAEEESIQA SMKKGKKDLA KSNRLADIER LSERHKWHVG
KLELLLRSLQ NGNVETQQVL DAQEAIKYYA EDGHNPDFCG EDETIYDDLP LGDEEVQFGM
NNDNDRVSSQ DTQSIQEDDV ESRQPSKSKS DSVPARRPST QMKSPLPVLA TLHLNGPSSS
STSSMKPAPP PARLPGETLK YASAAAAAAA SDKAGVGIAP LPPPPGASPA VSAAQLASKT
SSTASPMVQP AQPVQVQRLM SSAGSADESG SQSKSPTLSP SVTAASRPGT MPPTPAMSKI
ETSATTPSGT ASGSNKDRTV TNGQGKGKSR EEPAPEESVY HLPPGLQDLI HSFEVTKSRP
TAPQSTSVQR LLVASHSTCP EPGDAEKPRH YKPQTPYTTP LYYPQETLPI FDDPRLYETG
RIDTDTLFYL FYYRQSTYQQ YLAAKALKNQ SWRFHKLYQT WFQRHEEPKN ITEEYEQGTY
RFFDYESTWM NRRKGDFKFV YKYLEDDL
//
