ID E4UYS5_ARTGP Unreviewed; 318 AA.
AC E4UYS5;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 20 {ECO:0000256|RuleBase:RU364152};
DE AltName: Full=Mediator complex subunit 20 {ECO:0000256|RuleBase:RU364152};
GN Name=MED20 {ECO:0000256|RuleBase:RU364152};
GN ORFNames=MGYG_06257 {ECO:0000313|EMBL:EFR03255.1};
OS Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum
OS gypseum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Nannizzia.
OX NCBI_TaxID=535722 {ECO:0000313|Proteomes:UP000002669};
RN [1] {ECO:0000313|Proteomes:UP000002669}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4604 / CBS 118893 {ECO:0000313|Proteomes:UP000002669};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364152}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|RuleBase:RU364152}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364152}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 20 family.
CC {ECO:0000256|ARBA:ARBA00010743, ECO:0000256|RuleBase:RU364152}.
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DR EMBL; DS989826; EFR03255.1; -; Genomic_DNA.
DR RefSeq; XP_003171709.1; XM_003171661.1.
DR AlphaFoldDB; E4UYS5; -.
DR STRING; 535722.E4UYS5; -.
DR GeneID; 10026963; -.
DR VEuPathDB; FungiDB:MGYG_06257; -.
DR eggNOG; ENOG502SBIU; Eukaryota.
DR HOGENOM; CLU_075636_0_0_1; -.
DR InParanoid; E4UYS5; -.
DR OMA; PNHGFIY; -.
DR OrthoDB; 2071346at2759; -.
DR Proteomes; UP000002669; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR013921; Mediator_Med20.
DR Pfam; PF08612; Med20; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364152};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364152};
KW Reference proteome {ECO:0000313|Proteomes:UP000002669};
KW Transcription {ECO:0000256|RuleBase:RU364152};
KW Transcription regulation {ECO:0000256|RuleBase:RU364152}.
FT REGION 104..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 318 AA; 36015 MW; D48332FCF487D45D CRC64;
MSVTGVYYIP SNPELPTTAT RTVIDRFKAI HQPTRLGRWA LEFKLLRDTA SCLPAANFPH
NKVPTPRYMH FLSLSHYQNH GFIRISPRPE VDPLDPAVME KQMNSPPSLP ISAMGVSSQK
SPADGKDSTS LTQAEAHTTA IKTLDPQSYL SFFSMTTKFC QPLWNHRFTV VVTGGEVYEV
GDFRVRIGEV RQTVPRPRLR GAIVEIEYNG PGLRQSEPDL TREPEEDWDF VPLLPHHPPR
EVILPTDEDW ELGVMLIREL WENFSIPGAT ESIQVPGLGL ERRDYLGQSA SAQSTRKKAN
LVGVDLARQY MDVFKFYR
//
