ID E4UZM2_ARTGP Unreviewed; 876 AA.
AC E4UZM2;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=DNA mismatch repair protein mutS {ECO:0000313|EMBL:EFR03552.1};
GN ORFNames=MGYG_06548 {ECO:0000313|EMBL:EFR03552.1};
OS Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum
OS gypseum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Nannizzia.
OX NCBI_TaxID=535722 {ECO:0000313|Proteomes:UP000002669};
RN [1] {ECO:0000313|Proteomes:UP000002669}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4604 / CBS 118893 {ECO:0000313|Proteomes:UP000002669};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271}.
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DR EMBL; DS989826; EFR03552.1; -; Genomic_DNA.
DR RefSeq; XP_003172006.1; XM_003171958.1.
DR AlphaFoldDB; E4UZM2; -.
DR STRING; 535722.E4UZM2; -.
DR GeneID; 10027266; -.
DR VEuPathDB; FungiDB:MGYG_06548; -.
DR eggNOG; KOG0220; Eukaryota.
DR HOGENOM; CLU_002472_7_3_1; -.
DR InParanoid; E4UZM2; -.
DR OMA; KMTMLYK; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000002669; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR PANTHER; PTHR11361:SF21; MUTS PROTEIN HOMOLOG 4; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002669}.
FT DOMAIN 621..637
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 791..813
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 876 AA; 97833 MW; 589B04CD572B1E05 CRC64;
MRSHAPSTPL YPFTSDTRSP RPGTSRTAAG EHRVPRPTTA ATTSPSQEIV CAISESRGIS
PAVGLAFVNL STSEAVLSQI CDSQTYARTI HKLAVFEPTE VLLMNTSKEP SSKLYAAVGE
NLSHIRTVTV DRKYWSEQNC HDYVERLSFK EDTETIKMAL EGSYFSACCF AAALSYIELE
LSVTFAPHSL RLRYEPSEGS MMIDLATIVS LELIQNLQNA KSKDCLFGIL NETLTPMGAR
LLRSNILQPS TEVSKLNLRY DAVEELSSNE EMFFAVRQAL KSFLDSDRVL AALTVVLKKP
SISYAEQSIN NIIMLKTFIS CIRPIYEALI QTLLSETLND DVRYQSSALD LRNHRTYAVK
AGVNNLLDVA RQTYMEANDD VAELSARLSA EHGIPLDLRF ESGRHYYFRV RSTDLQGVVL
PDIFINVYRK KAFVEFQTLD LVKMNQKITD SHNEVISMSD RSIQELIDDV RTMISNLFRI
SEAIAMLDMI AAFAYIQATQ GYVRPEITPI LAIKAGRHPI REKIHSTKYI PNDIYASPQS
RFQIITGCNM SGKSTYIRSL ALMAVMAQIG SSVPAQYASF PIVHQLFARV SADDNQITNV
STFSTEMREM AYILRNIDAK SMVIVDELGR GTASTDGLAI SIAIAEALME THALVWFTTH
FHDLARIMEH RSGVINLHLA VDMSEPQSKI NMLYKIADGY VREQHYGLAL ARIFSLPPYL
IEVADEVSHR LTLAAQNRAK SSAAISLAKR RRLLLTLVEQ LMHVCNGVME GEALKEWLLR
LQREFTLRMT DTEPETESNV DDREISLSPR ETEGSHVDVE NIEAISQASS QSLPISPIFS
RKCPRGLVHH SIGNSELVLD SGNEQLGTTP SCTSNR
//
