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Database: UniProt
Entry: E4V1B4_ARTGP
LinkDB: E4V1B4_ARTGP
Original site: E4V1B4_ARTGP 
ID   E4V1B4_ARTGP            Unreviewed;       857 AA.
AC   E4V1B4;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   25-APR-2018, entry version 26.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=MGYG_06828 {ECO:0000313|EMBL:EFR03829.1};
OS   Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum
OS   gypseum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Nannizzia.
OX   NCBI_TaxID=535722 {ECO:0000313|Proteomes:UP000002669};
RN   [1] {ECO:0000313|Proteomes:UP000002669}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4604 / CBS 118893 {ECO:0000313|Proteomes:UP000002669};
RX   PubMed=22951933; DOI=10.1128/mBio.00259-12;
RA   Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA   Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA   Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA   Rossi A., Saif S., Samalova M., Saunders C.W., Shea T.,
RA   Summerbell R.C., Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A.,
RA   White T.C.;
RT   "Comparative genome analysis of Trichophyton rubrum and related
RT   dermatophytes reveals candidate genes involved in infection.";
RL   MBio 3:E259-E259(2012).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; DS989827; EFR03829.1; -; Genomic_DNA.
DR   RefSeq; XP_003170837.1; XM_003170789.1.
DR   STRING; 535722.XP_003170837.1; -.
DR   EnsemblFungi; EFR03829; EFR03829; MGYG_06828.
DR   GeneID; 10026080; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   InParanoid; E4V1B4; -.
DR   OrthoDB; EOG092C0YCY; -.
DR   Proteomes; UP000002669; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002669};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002669};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    426    451       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    472    489       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    579    599       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    611    628       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    648    667       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    760    783       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    789    813       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      101    135       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   857 AA;  97830 MW;  4C24A1FA0E041DFB CRC64;
     MGPTQDTLFR SADMSLTQLY IANEIGREVV SALGELGQVQ FRDLNEETTA FQKTFTSEIR
     RLDNVERQLR YFHAQMQKAD IEMRPSEEFS NNLAAPMASE IDELAERSES LEQRVSSLNE
     SYEALKRREV ELIERRWVLR EAGGFFDRAH GQTDEIRQSF DNDEAPLLRD IEQQPPRGQN
     GDAQHSSFSV MDIGFVAGVI PRDRIGAFER ILWRTLRGNL YMNQSEIPDP IVDPATNEEI
     HKNVFVIFAH GKEIIAKIRK ISESLGANLH AVDENSELRR DQIHDVNSRL TDVGNVLRNT
     KNALDAELTQ IARSLAAWMI IVKKEKAVYH ALNKFSYDQA RKTLIAEAWC PTNSLGLIKS
     TLQDVNDRAG LSVPTIVNQI RTNKTPPTYM KTNKFTQSFQ LIVDAYGTSK YQEVNPGLPT
     IVTFPFFFAV MFGDFGHAML MTMLAVTLIL FERKLGKTKL DELSSMAFSG RYIMLMMGIF
     AMYTGLIYND IFSKSMDLFQ SAWAWPEDFN ENETVFAELK GSYRYPFGLD WGWHGTDNNL
     LFTNSYKMKL SIILGWSHMT YSLCQSFVNA RHFKKPIEIW GNFIPGMIFF QSIFGYLVFT
     IIYKWSVDWK GLGLPAPGLL NMLIFMFLQP GRVDDELYHG QATVQKILLF VALIQVPILL
     LLKPLYLRWE HNRARALGYR GLNEAAHTSA VDDDDEQQNL ISGQRDSMGD GEGIGMVTQD
     MNEGEEQHEF EFSEEMIHQV IHTIEFCLNC VSHTASYLRL WALSLAHQQL SSVLWSMTLG
     GAFTQSSPVL RVIMTIITFY LWFVLTISIL CVMEGTSAML HSLRLHWVEA MSKHFIGDGI
     PFTPFSFEAI LQEDPVD
//
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