ID E4V4J6_ARTGP Unreviewed; 451 AA.
AC E4V4J6;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Cytochrome P450 {ECO:0008006|Google:ProtNLM};
GN ORFNames=MGYG_07922 {ECO:0000313|EMBL:EFR04920.1};
OS Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum
OS gypseum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Nannizzia.
OX NCBI_TaxID=535722 {ECO:0000313|Proteomes:UP000002669};
RN [1] {ECO:0000313|Proteomes:UP000002669}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4604 / CBS 118893 {ECO:0000313|Proteomes:UP000002669};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS989829; EFR04920.1; -; Genomic_DNA.
DR RefSeq; XP_003169755.1; XM_003169707.1.
DR AlphaFoldDB; E4V4J6; -.
DR STRING; 535722.E4V4J6; -.
DR GeneID; 10024986; -.
DR VEuPathDB; FungiDB:MGYG_07922; -.
DR eggNOG; KOG0157; Eukaryota.
DR HOGENOM; CLU_001570_5_11_1; -.
DR InParanoid; E4V4J6; -.
DR OMA; TCLEYRK; -.
DR OrthoDB; 2954533at2759; -.
DR Proteomes; UP000002669; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24305; CYTOCHROME P450; 1.
DR PANTHER; PTHR24305:SF227; P450, PUTATIVE (EUROFUNG)-RELATED; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000002669};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 42..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 422..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 451 AA; 50887 MW; 9B58AFE58578AB54 CRC64;
MVLLGLGLSA ALTFFLVSYL PKYSIAGSFA WTLPALFTCY LLLRALYFVI LYPIFFTPYR
HLPVPPGRSV WNGHFKILQA SSQGTPSAKW TREVPNDGLI RYYFMLNRER LLVTSTKALA
DVLVNRAYDF EKTRALVASI SWVTGTGVIL AEGDVHRLQR KHLNPAFSFR HIKELYPIFW
QKSVEMTERI AQDIAALPTN EKIVCFADYT GRATLEIIGL AGMGYDLDSV NELREEYRKM
FSTPGRFTGI IRNIVFLTWP DLFFYLPLPY VKAITAASQK TRTISRQLVQ RKRHELSSKK
IDDSSGDIIS VALESGNFTE EGLVDQIMTF LAAGHETTSV SLQYGTRILC THPEVQSRLR
EEVRAKIPST GQNRDANGLP HISSSLLDTL PYLNAFCNEL FRFYPPVTVT SRQAIRDTVI
AGQPIKKGTT SPLHPEQPTE TRSSGTRCRC L
//
