ID E4V6P4_ARTGP Unreviewed; 2143 AA.
AC E4V6P4;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Non-reducing polyketide synthase nscA {ECO:0000256|ARBA:ARBA00018393};
DE AltName: Full=Conidial yellow pigment biosynthesis polyketide synthase nscA {ECO:0000256|ARBA:ARBA00031359};
DE AltName: Full=Neosartoricin B biosynthesis protein A {ECO:0000256|ARBA:ARBA00033379};
GN ORFNames=MGYG_08684 {ECO:0000313|EMBL:EFQ96760.1};
OS Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum
OS gypseum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Nannizzia.
OX NCBI_TaxID=535722 {ECO:0000313|Proteomes:UP000002669};
RN [1] {ECO:0000313|Proteomes:UP000002669}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4604 / CBS 118893 {ECO:0000313|Proteomes:UP000002669};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
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DR EMBL; DS989831; EFQ96760.1; -; Genomic_DNA.
DR RefSeq; XP_003169137.1; XM_003169089.1.
DR STRING; 535722.E4V6P4; -.
DR GeneID; 10024371; -.
DR VEuPathDB; FungiDB:MGYG_08684; -.
DR eggNOG; KOG1202; Eukaryota.
DR HOGENOM; CLU_000022_6_0_1; -.
DR InParanoid; E4V6P4; -.
DR OMA; NDWGETN; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000002669; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0009403; P:toxin biosynthetic process; IEA:UniProt.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR030918; PT_fungal_PKS.
DR InterPro; IPR032088; SAT.
DR InterPro; IPR001031; Thioesterase.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR04532; PT_fungal_PKS; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF40; NORSOLORINIC ACID SYNTHASE STCA; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF14765; PS-DH; 1.
DR Pfam; PF16073; SAT; 1.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002669};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 377..811
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1650..1728
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1756..1834
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2143 AA; 234983 MW; BE21C3B4F83CD14F CRC64;
MVNQLHLYLF GDLTYDVSPK LQPLLHSELY PLLRSFFDRA CDKLRAEIGR LPAQDKEFFP
RFSSIAELLT WRNSHSRSNP AIENALTCIY QLGQFIHQYE GIGQAYLTPQ ETCVSGICTG
ALSAAAVSCC RTTSEIVPIA VQTILVAFRL GMCTLRASGA IDPSEGAWSM VVSCDSTDKI
QERLSKFSRE NNLPVTSRPW ISAYGEENWV SISAPASTLL ALRSSEILSG MRSRSLEIHS
PYHAQHLFSK IDIDAILETT DFQEWERYRA VRSIVSSSTG AIIEGDCFRS CLEAALAQIL
IEPIRWAELT QGLAAFITSI NAKRFHVIPI ATNAETTLMT SLRSKMQLEA PEFSSKDETE
KAEPINRNAQ ESMVRGRSKI AIVGLSGRYP SAENNEEFWD LIFCGLDVHK TVPDLHWSAQ
THVDPTGKRK NTSATPYGCW LDHPEAFDGL FFNMSPREAP QVDPAQRIAL MTAYEAMEQA
GIVPGATPST RHDRVGVFYG VTSNDWMETN SAQNIDTYFI PGGNRAFIPG RINYFFKFSG
PSYSVDTACS SSLASLHIAC NSLWQRDIDT AIAGGTNILT NPDFTAGLDR GHFLSRTGNC
KTFDDDADGY CRGEGVGTVI LKRLEDAIAD KDPIHGLILG TYTNHSAEAE SITRPHVGAQ
RDIMRNILSN SGVDPYSVSY VELHGTGTQA GDAREMTSVL DTFAPADARR HRQPHESLHL
GSVKSNIGHG EAAAGVSALI KVLLMLRNST IPPHCGIKNK INSSFPTDLD ARNVYIAKSA
VPWPAKEGQP RRVFINNFSA AGGNSALVLE EKPIEAEIKG TDPRIAHVVT VSAKSAVSLS
RNIQSLVDYI EKHKEEPLFL PQLSYTTTAR RIHHQHRVAV TGVAAVDIKA ALETAAANGD
GKLRARVRPK VTFTYTGQGA QYVGMAKQLY ILFDQFKRDI NRFNGIAEKL GFPSFLDVIK
GEPTQDPKDI SPVTLQLSSV CMQIALSRLL ISWNVMPDSV IGHSLGEYAA LNTASVLSDT
DTIFLVGRRA QLLEQLCTLG THNMLVVKAS LSTVQGALEG TEFEVACINA PEETVIAGPN
TQIEALKESL NSNGFKTKII QVPFAYHSSQ VDAILGDFET IATGVRFRKP TIPVISPLLA
EVIVDEGIIC PSYLRRHCRE TVNFLGAIQR VKDTGVVKEK SFFVEIGPHP IVTGMVKAVL
GTSVTSLPTL QRNRGDLKVI TELLVALYSA GTDLRWNEYH RDFEASHKVL ELPAYNWDLK
NYWMQYVNDW SLRKGDPPLV VGPSSLTSTT IHKVLDDKID KIVVESDMTR EDFNPLVQGH
EVDGVPLCTP SVYADIALSI GKYLIERYHP EIETNLVDVA NMTVLKALIA RAQGPQPLRT
IATVDWAAKK ANVSFRSFDK SGEPKVEHAT CEINFTDRSR LKLLEGSTAN TKARMGAMRE
TLGSGETQRF NRAMVYKMIG PLAQFHRDYQ PLDEVIIDSN SLEVSSQVNF KGVQAAGDFF
AHPAYIDGLT QAGGFVMNCN DSNDLAVEVF VNHGWESLQL YEPLQKEKKY KTFCHMSPGD
NRKFHGDVVV FDESDRIVAS YKGIVFQGVP RRVLRFFLKP EAPAAPRGQA NQKSAARPTP
VAPVITAAPA TTPKSIAKPA HVPAAAPAVG SKSSKVKQAF QIMSEEAGVP VDDLTDDCVF
TDMGIDSLLA LVITSRFREE LELDGELDDI FLTYTSGKAL RDYLAKQYGS DIPVAVEPAP
LPVAAAKIEP VVTSRISLGA DCAAALAIVS EESGIPVAEL SDECILAEIG IDSLLALVIV
SRFKEELDVD IDSQAVFTDS FMIRDLKLFF GKEESANTTQ APSILMESSD ENTMSSMTPP
DSSSDYDISE KPECVAVPPT TSVLLQGIAR HAEKILFLFP DGSGSATSYS AIPRLSPRVA
VIGLNSPYNK IPELFRCTLD DLIDSYIDEV RRRQPTGPYY FGGWSAGGIL AYRAAQKLIE
GGEKVLDLIL VDSPVPRGLD KLPQHFYDHC NKYQVFGHRA GPTKGQTKAP AWLIPHFNAT
IDTLHDYHAS PLPAGKTPRT TIIWAGESVI DGVNVPKLQS HADDTQGMKF LSEKRTDFSA
AGWEAVFPGG EIILERMERA NHFSMMKGEH AGKLAAIMKA ALA
//
