ID E4WLV5_9PHYC Unreviewed; 220 AA.
AC E4WLV5;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=mRNA capping enzyme {ECO:0000313|EMBL:CBI70078.1};
GN ORFNames=OtV2_079 {ECO:0000313|EMBL:CBI70078.1};
OS Ostreococcus tauri virus 2.
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC Algavirales; Phycodnaviridae; Prasinovirus.
OX NCBI_TaxID=696472 {ECO:0000313|EMBL:CBI70078.1, ECO:0000313|Proteomes:UP000202189};
RN [1] {ECO:0000313|Proteomes:UP000202189}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21289127; DOI=10.1128/JVI.02131-10;
RA Weynberg K.D., Allen M.J., Gilg I.C., Scanlan D.J., Wilson W.H.;
RT "Genome sequence of Ostreococcus tauri virus OtV-2 throws light on the role
RT of picoeukaryote niche separation in the ocean.";
RL J. Virol. 85:4520-4529(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-
CC end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + diphosphate;
CC Xref=Rhea:RHEA:67012, Rhea:RHEA-COMP:17165, Rhea:RHEA-COMP:17166,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:167616, ChEBI:CHEBI:167617; EC=2.7.7.50;
CC Evidence={ECO:0000256|ARBA:ARBA00024268};
CC -!- SIMILARITY: In the N-terminal section; belongs to the dsDNA virus mRNA
CC guanylyltransferase family. {ECO:0000256|ARBA:ARBA00008556}.
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DR EMBL; FN600414; CBI70078.1; -; Genomic_DNA.
DR RefSeq; YP_004063512.1; NC_014789.1.
DR GeneID; 10021061; -.
DR KEGG; vg:10021061; -.
DR OrthoDB; 14402at10239; -.
DR Proteomes; UP000202189; Genome.
DR GO; GO:0004482; F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity; IEA:InterPro.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR004971; mRNA_G-N7_MeTrfase_dom.
DR InterPro; IPR039753; RG7MT1.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR12189:SF2; MRNA CAP GUANINE-N7 METHYLTRANSFERASE; 1.
DR PANTHER; PTHR12189; MRNA GUANINE-7- METHYLTRANSFERASE; 1.
DR Pfam; PF03291; mRNA_G-N7_MeTrfase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000202189};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 6..136
FT /note="MRNA cap 0 methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF03291"
SQ SEQUENCE 220 AA; 25465 MW; CCD002AF25DE2204 CRC64;
MEEIRRNHNN AKRELIQCVT REGHQILDVG CGFGGDLQKW HKCGANMSMC DPEPSALVEA
RSRAKNMHMR VNFYEGDIHN CPNRKFDIVC YNFSLHYIFE SHGKFFSSLR EIKKRMKPGG
RLIGIIPDSE KIIFRTPLKD HMGNFFLTRN HGNGGYGEKL FVNLVDTPFY ADGPKSEPIA
YRDLLVTHLE EMGFKLELWE GLTGNPISEL YSKFIFVYKR
//
