ID E4WTA4_OIKDI Unreviewed; 591 AA.
AC E4WTA4;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Sulfotransferase {ECO:0000256|RuleBase:RU361155};
DE EC=2.8.2.- {ECO:0000256|RuleBase:RU361155};
GN ORFNames=GSOID_T00006178001 {ECO:0000313|EMBL:CBY07093.1};
OS Oikopleura dioica (Tunicate).
OC Eukaryota; Metazoa; Chordata; Tunicata; Appendicularia; Copelata;
OC Oikopleuridae; Oikopleura.
OX NCBI_TaxID=34765 {ECO:0000313|EMBL:CBY07093.1};
RN [1] {ECO:0000313|EMBL:CBY07093.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21097902; DOI=10.1126/science.1194167;
RA Denoeud F., Henriet S., Mungpakdee S., Aury J.M., Da Silva C.,
RA Brinkmann H., Mikhaleva J., Olsen L.C., Jubin C., Canestro C.,
RA Bouquet J.M., Danks G., Poulain J., Campsteijn C., Adamski M., Cross I.,
RA Yadetie F., Muffato M., Louis A., Butcher S., Tsagkogeorga G., Konrad A.,
RA Singh S., Jensen M.F., Cong E.H., Eikeseth-Otteraa H., Noel B.,
RA Anthouard V., Porcel B.M., Kachouri-Lafond R., Nishino A., Ugolini M.,
RA Chourrout P., Nishida H., Aasland R., Huzurbazar S., Westhof E., Delsuc F.,
RA Lehrach H., Reinhardt R., Weissenbach J., Roy S.W., Artiguenave F.,
RA Postlethwait J.H., Manak J.R., Thompson E.M., Jaillon O., Du Pasquier L.,
RA Boudinot P., Liberles D.A., Volff J.N., Philippe H., Lenhard B.,
RA Roest Crollius H., Wincker P., Chourrout D.;
RT "Plasticity of animal genome architecture unmasked by rapid evolution of a
RT pelagic tunicate.";
RL Science 330:1381-1385(2010).
CC -!- SIMILARITY: Belongs to the sulfotransferase 1 family.
CC {ECO:0000256|RuleBase:RU361155}.
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DR EMBL; FN653016; CBY07093.1; -; Genomic_DNA.
DR AlphaFoldDB; E4WTA4; -.
DR InParanoid; E4WTA4; -.
DR Proteomes; UP000001307; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR037359; NST/OST.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR10605:SF65; HEPARAN SULFATE GLUCOSAMINE 3-O-SULFOTRANSFERASE 6; 1.
DR PANTHER; PTHR10605; HEPARAN SULFATE SULFOTRANSFERASE; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR637359-3};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001307};
KW Transferase {ECO:0000256|RuleBase:RU361155};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 291..568
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
FT ACT_SITE 299
FT /note="For sulfotransferase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-1"
FT BINDING 397
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 531
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT DISULFID 532..543
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-3"
SQ SEQUENCE 591 AA; 65673 MW; E802ADBBBC0B0423 CRC64;
MARCGISLTC LSTVFLGMML GLSILLIHSM LLTERQRLEI LENEILDQQA DWKAQWEQAQ
AAQKAVQDSQ ASYLHDELEK FEKQVESELG IVDGAPPAPV AAAQVQAQPA PAFVPELAAQ
VIAQAPETLA PMVDDYAAAA APAPVFAAPA PAFEAAPAPV FEAALAPAYI PEAAPAQAFV
PEAPAPAYVP DAAPAAPAYA PAAPAFGAVP APQAALPYGA VLPVGAVGIG VDGQEWIFIK
KGENLIKILQ KPIYQIPTFD PAPKTVDQIM VGLHERIKRR KTMPKTQHLP SFIIIGVKKC
GTSALSRFLK IHPDLASAGE TFFFANNFKD GLDYYKSKMP NTTDDVLTYE KTPNYYRLPV
VPDRVRNFQS QISKASGIKK EVKMIYITCD PVRRALSDFL HSRTNEGGSE PAAGEFEAFI
GVRFSKMEEE MATIKADHGE EWHDEIYNMY KERRGWFNYT DPISNMIVNG AYSIFYKRWL
ENFDQRQLLV IDGTEMISNP GAVVVQTQQF LNIERIIDEN NFIFDEERGF YCYTRTGDET
KYCIKGQNKT PTKTLSDDMR VRLFNFFEPF SQRLASDLAR EPFNWNWNPA L
//
