ID E4WWG8_OIKDI Unreviewed; 824 AA.
AC E4WWG8;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 13-SEP-2023, entry version 35.
DE RecName: Full=Amino acid permease/ SLC12A domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=GSOID_T00009240001 {ECO:0000313|EMBL:CBY21472.1};
OS Oikopleura dioica (Tunicate).
OC Eukaryota; Metazoa; Chordata; Tunicata; Appendicularia; Copelata;
OC Oikopleuridae; Oikopleura.
OX NCBI_TaxID=34765 {ECO:0000313|EMBL:CBY21472.1};
RN [1] {ECO:0000313|EMBL:CBY21472.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21097902; DOI=10.1126/science.1194167;
RA Denoeud F., Henriet S., Mungpakdee S., Aury J.M., Da Silva C.,
RA Brinkmann H., Mikhaleva J., Olsen L.C., Jubin C., Canestro C.,
RA Bouquet J.M., Danks G., Poulain J., Campsteijn C., Adamski M., Cross I.,
RA Yadetie F., Muffato M., Louis A., Butcher S., Tsagkogeorga G., Konrad A.,
RA Singh S., Jensen M.F., Cong E.H., Eikeseth-Otteraa H., Noel B.,
RA Anthouard V., Porcel B.M., Kachouri-Lafond R., Nishino A., Ugolini M.,
RA Chourrout P., Nishida H., Aasland R., Huzurbazar S., Westhof E., Delsuc F.,
RA Lehrach H., Reinhardt R., Weissenbach J., Roy S.W., Artiguenave F.,
RA Postlethwait J.H., Manak J.R., Thompson E.M., Jaillon O., Du Pasquier L.,
RA Boudinot P., Liberles D.A., Volff J.N., Philippe H., Lenhard B.,
RA Roest Crollius H., Wincker P., Chourrout D.;
RT "Plasticity of animal genome architecture unmasked by rapid evolution of a
RT pelagic tunicate.";
RL Science 330:1381-1385(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR EMBL; FN653017; CBY21472.1; -; Genomic_DNA.
DR AlphaFoldDB; E4WWG8; -.
DR InParanoid; E4WWG8; -.
DR Proteomes; UP000001307; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827:SF72; GH08340P; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF03522; SLC12; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001307};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 33..57
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 63..88
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 109..130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 188..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 255..276
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 383..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 408..430
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 451..479
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 35..523
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 546..620
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
SQ SEQUENCE 824 AA; 89866 MW; CDBC7052774A979D CRC64;
MSDSDTELLI DHDLNSNGSL GEAPSTQRTL NTFFGVIVPC CLSMFSVVLF LRMGFIIGQA
GLIQTLIMLV IAFLIIALTV TSVCAISTNG AVEAGGAYFM ISRALGPEMG ASIGLMFYLA
NAAAVAMYIF GMCETIIDDF GPGGQLLPNE NSTGIPTSQW IEYGYGTALL FLVAVICLVG
ADIYAKAVFG IFIVVGSAII CVIVSFFVEK DMQVPVVNPD WPNRTELYTG FSSVTFHSNL
YSNYTYDYTI PNSPIMGFID VFAILFNGCT GIMAGANMSG ELKNPSKSIP LGTIAACSIV
CFTYILLMMF IAATCPKALL NNNYTFLQAI NFWPPIVFIG IFFSSFSAAL SSLIGASRVL
HAMANDGMFG PALRLMKKTN SKGNPYVAVI VTWGIIQVVL LIGKLNAIAP LVTIFFLLAY
TACDLACLGL DWASAPNFRP TFKYFSWHTA LLGVISTMAV MFLVNYIWAL AAMAIMIILS
AISHYTAPQV AWGSISQALI FHQVRKYALK MNVQDASVDS WRPGILFLVK DITTSVEGLL
FVNDLKKSGL LVLGHVNLGN IDQEDMDSSK RKLNAWYDFV KRSNVKAFVE HTTCPDLRLG
AEQLLRLSGL GGMKANTLVM SIDSPIESTK DIITDAVRLD RNVVLMKNVT SFNRNLLDGR
NQNFIDIWPT SLTSPGFIIG TVDSIKSDAN AQFLLQLGCL LSRSHSWKST AQLRIFIPVA
PGTDFQASQK SFKAYFMELR INAVLVLVTV EYDQLELMDE DYVLWVNSLI LSKKSGQTGV
TFVQLPSTVD TCMAFISPEK GSASYLTDIG PVVMTWGLKN VISV
//
