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Database: UniProt
Entry: E4WZQ8_OIKDI
LinkDB: E4WZQ8_OIKDI
Original site: E4WZQ8_OIKDI 
ID   E4WZQ8_OIKDI            Unreviewed;       254 AA.
AC   E4WZQ8;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   08-MAY-2019, entry version 37.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:CBY22654.1};
GN   ORFNames=GSOID_T00013422001 {ECO:0000313|EMBL:CBY22654.1};
OS   Oikopleura dioica (Tunicate).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Appendicularia; Copelata;
OC   Oikopleuridae; Oikopleura.
OX   NCBI_TaxID=34765 {ECO:0000313|EMBL:CBY22654.1};
RN   [1] {ECO:0000313|EMBL:CBY22654.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21097902; DOI=10.1126/science.1194167;
RA   Denoeud F., Henriet S., Mungpakdee S., Aury J.M., Da Silva C.,
RA   Brinkmann H., Mikhaleva J., Olsen L.C., Jubin C., Canestro C.,
RA   Bouquet J.M., Danks G., Poulain J., Campsteijn C., Adamski M.,
RA   Cross I., Yadetie F., Muffato M., Louis A., Butcher S.,
RA   Tsagkogeorga G., Konrad A., Singh S., Jensen M.F., Cong E.H.,
RA   Eikeseth-Otteraa H., Noel B., Anthouard V., Porcel B.M.,
RA   Kachouri-Lafond R., Nishino A., Ugolini M., Chourrout P., Nishida H.,
RA   Aasland R., Huzurbazar S., Westhof E., Delsuc F., Lehrach H.,
RA   Reinhardt R., Weissenbach J., Roy S.W., Artiguenave F.,
RA   Postlethwait J.H., Manak J.R., Thompson E.M., Jaillon O.,
RA   Du Pasquier L., Boudinot P., Liberles D.A., Volff J.N., Philippe H.,
RA   Lenhard B., Roest Crollius H., Wincker P., Chourrout D.;
RT   "Plasticity of animal genome architecture unmasked by rapid evolution
RT   of a pelagic tunicate.";
RL   Science 330:1381-1385(2010).
CC   -!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell
CC       membrane {ECO:0000256|SAAS:SAAS00578413}; Multi-pass membrane
CC       protein {ECO:0000256|SAAS:SAAS00578413}. Cell membrane
CC       {ECO:0000256|SAAS:SAAS00569391}; Multi-pass membrane protein
CC       {ECO:0000256|SAAS:SAAS00569391}.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
CC       family. {ECO:0000256|SAAS:SAAS00978283}.
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DR   EMBL; FN653019; CBY22654.1; -; Genomic_DNA.
DR   InParanoid; E4WZQ8; -.
DR   GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022848; F:acetylcholine-gated cation-selective channel activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   Gene3D; 2.70.170.10; -; 1.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR   PANTHER; PTHR18945; PTHR18945; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR00254; NICOTINICR.
DR   SUPFAM; SSF63712; SSF63712; 1.
DR   SUPFAM; SSF90112; SSF90112; 1.
PE   3: Inferred from homology;
KW   Cell junction {ECO:0000256|SAAS:SAAS00469532};
KW   Cell membrane {ECO:0000256|SAAS:SAAS00458000};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00469536};
KW   Ion channel {ECO:0000256|SAAS:SAAS00458066};
KW   Ion transport {ECO:0000256|SAAS:SAAS00457919};
KW   Ligand-gated ion channel {ECO:0000256|SAAS:SAAS00172123};
KW   Membrane {ECO:0000256|SAAS:SAAS00978300, ECO:0000256|SAM:Phobius};
KW   Postsynaptic cell membrane {ECO:0000256|SAAS:SAAS00469538};
KW   Receptor {ECO:0000256|SAAS:SAAS00172128};
KW   Synapse {ECO:0000256|SAAS:SAAS00103537};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00978734,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00978768,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00081549}.
FT   TRANSMEM    147    172       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    178    196       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    208    230       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        5    145       Neur_chan_LBD. {ECO:0000259|Pfam:
FT                                PF02931}.
FT   DOMAIN      153    246       Neur_chan_memb. {ECO:0000259|Pfam:
FT                                PF02932}.
SQ   SEQUENCE   254 AA;  29542 MW;  23470F3D144B5555 CRC64;
     MPVVDWTDDR LSWNPMDYKN ISVTNINSQL IWKPGTVFYN NKDGSFETKF KTKLKVMSNG
     YISWMPPALY KSTYRQKCSL IFRSTDFDAR SLDFSYDFAI STSYVEGSNI SAEWVLLRTN
     IFIVDSSDSD LSFREIHFEY HFQRMPLFYI LNMILPIWLM FFLSIFVFYL PTDACEKMTL
     SISILIGQTV FLTLLAKHTP ETSMEIPLLS SYLLFTIMMV SFSVIMSVIV CNVHFRSSAT
     HKVCSTSNHL DTEY
//
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