ID   E4X861_OIKDI            Unreviewed;       788 AA.
AC   E4X861;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   RecName: Full=SMB domain-containing protein {ECO:0000259|PROSITE:PS50958};
GN   ORFNames=GSOID_T00003754001 {ECO:0000313|EMBL:CBY18884.1};
OS   Oikopleura dioica (Tunicate).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Appendicularia; Copelata;
OC   Oikopleuridae; Oikopleura.
OX   NCBI_TaxID=34765 {ECO:0000313|EMBL:CBY18884.1};
RN   [1] {ECO:0000313|EMBL:CBY18884.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21097902; DOI=10.1126/science.1194167;
RA   Denoeud F., Henriet S., Mungpakdee S., Aury J.M., Da Silva C.,
RA   Brinkmann H., Mikhaleva J., Olsen L.C., Jubin C., Canestro C.,
RA   Bouquet J.M., Danks G., Poulain J., Campsteijn C., Adamski M., Cross I.,
RA   Yadetie F., Muffato M., Louis A., Butcher S., Tsagkogeorga G., Konrad A.,
RA   Singh S., Jensen M.F., Cong E.H., Eikeseth-Otteraa H., Noel B.,
RA   Anthouard V., Porcel B.M., Kachouri-Lafond R., Nishino A., Ugolini M.,
RA   Chourrout P., Nishida H., Aasland R., Huzurbazar S., Westhof E., Delsuc F.,
RA   Lehrach H., Reinhardt R., Weissenbach J., Roy S.W., Artiguenave F.,
RA   Postlethwait J.H., Manak J.R., Thompson E.M., Jaillon O., Du Pasquier L.,
RA   Boudinot P., Liberles D.A., Volff J.N., Philippe H., Lenhard B.,
RA   Roest Crollius H., Wincker P., Chourrout D.;
RT   "Plasticity of animal genome architecture unmasked by rapid evolution of a
RT   pelagic tunicate.";
RL   Science 330:1381-1385(2010).
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DR   EMBL; FN653028; CBY18884.1; -; Genomic_DNA.
DR   AlphaFoldDB; E4X861; -.
DR   InParanoid; E4X861; -.
DR   Proteomes; UP000001307; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR   Gene3D; 4.10.410.20; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR037359; NST/OST.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036024; Somatomedin_B-like_dom_sf.
DR   InterPro; IPR001212; Somatomedin_B_dom.
DR   InterPro; IPR000863; Sulfotransferase_dom.
DR   PANTHER; PTHR10605:SF65; HEPARAN SULFATE GLUCOSAMINE 3-O-SULFOTRANSFERASE 6; 1.
DR   PANTHER; PTHR10605; HEPARAN SULFATE SULFOTRANSFERASE; 1.
DR   Pfam; PF01033; Somatomedin_B; 1.
DR   Pfam; PF00685; Sulfotransfer_1; 1.
DR   SMART; SM00201; SO; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF90188; Somatomedin B domain; 1.
DR   PROSITE; PS50958; SMB_2; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW   ECO:0000256|PIRSR:PIRSR637359-3}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001307};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        397..415
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          47..90
FT                   /note="SMB"
FT                   /evidence="ECO:0000259|PROSITE:PS50958"
FT   REGION          274..314
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        274..291
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        708..722
FT                   /evidence="ECO:0000256|PIRSR:PIRSR637359-3"
SQ   SEQUENCE   788 AA;  89324 MW;  9AECFBD08733A7A2 CRC64;
     MERKDCCESD SVTQDCLGLC DGAQTLFWSK QYSKCSSVNR QIYSCWSRTT CVGRCNDKPR
     TDHKCQCDLD CMMRGDCCID MPFACKVDLP IKISYWPSQS LSCAKTINFS DYQRAKGVHQ
     MENLLIDPKK PSPYVALGLD GFVGKLKTFF NVKIDGAYRF YFMLGSKDFG QVKIDGIKIA
     DLICSANPKP MQVDLLLPFG GHKLEIVFAH TGGAHQLKVA YEGPDTAMRP SKIQVLKEAD
     VFEMGLPAEL ASTTTTTAVP LTRPGENIVK STTTKASIGW KNPNVPSVQP KTRRPAPTRA
     PQTERPLSKS SEVQTETERF DIRIIVGLSL ESGLYSNKNV LIQERNYLLT HRMSSFSQYV
     TSTADYIDPP ERRLIEIEDE DLNDTKIERK LDKCRKYLMI GLALIGILYY IAFEFDGMES
     QTSMKDAAIS WVQATGSGAN RPAIVAPDPY KLPPPNDYDE PVHGFPKAYI IGAPRCGCHV
     LRQYMEHHPQ MFFTDEQNLH FWDDKYSQGV EWYKQKIPAV KPWQISVDYT SEYLIKPEVP
     QRMIDELPNN QTRIIMMVCD PIERAELEFF EIYNNLDTNH ADWKAKIDAV GDIITDFPSF
     ADLYTKFLST IRDNPSQVSK YGVRDFEDLI ANIKTIRPEA SILTTSLFDI HIRRWLRVFD
     RGNILIMDGR QLQTAPIVAV RRVQNFLRIE DAIPSKAFSF NATAGLFCVN NGLFSDFNEV
     VCPARDSFVL PDAAPRISAK AKEKLKDWFA PHMASFAFMT NDTFPWAYLP QVAHIDMPTG
     NGWADGWT
//