ID E4X9L9_OIKDI Unreviewed; 1335 AA.
AC E4X9L9;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Rad50/SbcC-type AAA domain-containing protein {ECO:0000259|Pfam:PF13476};
GN ORFNames=GSOID_T00005013001 {ECO:0000313|EMBL:CBY08442.1};
OS Oikopleura dioica (Tunicate).
OC Eukaryota; Metazoa; Chordata; Tunicata; Appendicularia; Copelata;
OC Oikopleuridae; Oikopleura.
OX NCBI_TaxID=34765 {ECO:0000313|EMBL:CBY08442.1};
RN [1] {ECO:0000313|EMBL:CBY08442.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21097902; DOI=10.1126/science.1194167;
RA Denoeud F., Henriet S., Mungpakdee S., Aury J.M., Da Silva C.,
RA Brinkmann H., Mikhaleva J., Olsen L.C., Jubin C., Canestro C.,
RA Bouquet J.M., Danks G., Poulain J., Campsteijn C., Adamski M., Cross I.,
RA Yadetie F., Muffato M., Louis A., Butcher S., Tsagkogeorga G., Konrad A.,
RA Singh S., Jensen M.F., Cong E.H., Eikeseth-Otteraa H., Noel B.,
RA Anthouard V., Porcel B.M., Kachouri-Lafond R., Nishino A., Ugolini M.,
RA Chourrout P., Nishida H., Aasland R., Huzurbazar S., Westhof E., Delsuc F.,
RA Lehrach H., Reinhardt R., Weissenbach J., Roy S.W., Artiguenave F.,
RA Postlethwait J.H., Manak J.R., Thompson E.M., Jaillon O., Du Pasquier L.,
RA Boudinot P., Liberles D.A., Volff J.N., Philippe H., Lenhard B.,
RA Roest Crollius H., Wincker P., Chourrout D.;
RT "Plasticity of animal genome architecture unmasked by rapid evolution of a
RT pelagic tunicate.";
RL Science 330:1381-1385(2010).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the SMC family. RAD50 subfamily.
CC {ECO:0000256|ARBA:ARBA00009439}.
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DR EMBL; FN653031; CBY08442.1; -; Genomic_DNA.
DR InParanoid; E4X9L9; -.
DR Proteomes; UP000001307; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038729; Rad50/SbcC_AAA.
DR PANTHER; PTHR18867:SF12; DNA REPAIR PROTEIN RAD50; 1.
DR PANTHER; PTHR18867; RAD50; 1.
DR Pfam; PF13476; AAA_23; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001307};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 7..262
FT /note="Rad50/SbcC-type AAA"
FT /evidence="ECO:0000259|Pfam:PF13476"
FT REGION 516..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 197..300
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 330..357
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 451..478
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 743..792
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 834..921
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 980..1028
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1335 AA; 154474 MW; 42C69C66E40145A5 CRC64;
MVFLKTIKIS GIRSIGPGEE HEVEIKFQRP FTLISGQNGA GKTTIIECLK YATSGSFPPG
TTKATVTGKK RKAVNTTKVP AQVFLELEIP SECGKPQLVQ INRKLEGTLK DGDFTTKSLE
GTITVKDKRS GEIISSKVQK VEELNKHIRG LLGVNKPVLE YAVFCHQDET LWPFEEAKLL
KAKFDEIFQS AEYVKSLEQI KKAYKEASSE IVIMKERQRS ETYRVEHFRK QKERENKLTI
EVAEARKEIQ TLDEQLDKVE EEEDQCATVL RDQRNKMEAV KSLQARCREI NEDVKRFKEM
EGVPKIVSSH NESITEIEES ILNSEKGDDR RILEDQINEK QDEKKSLEEK LKSCQTRLDN
EVMTIQQFDS DEKKIADIFE REHNRFPNVE TSGPLNEKES QEDFIDGVSE VLDHQREQIE
ITEKKRDEEV GIIDEKLKEN SVEKTTLETT ISLKKKQMTT EKRKIEEIEE QLRSSSQIAD
RHSRFVRKRD ALDKDYSAVS WETEFEKIDE SLTQNSDEKD ILTQKREKLE EEEEKSQIME
DLEREKKSKE ADVSRMENEV RKSRDVLEDI FSQIEGFTDV EAVSKDDLEA WSMKYSKDFS
RNEDALKRQV QALFQKQSEE KQLKKDHVKI QTRLVTNREK IESEILGELQ DEKSKLNELT
CEETELFEKV QAMEEGKKLF KQFLSSVQKK KGCPVCTSDL SGSKLDQTIE FCKSNMSFKN
GPQMKADLED LRTDITKKKE HIVVLEEIEK DEAEEAKVTA QQKTLKSQIL RINDDKIKLE
KSKKTLETIK NKLQLTAFDQ FEIFTSANQQ LEPSKARLTK IDREIFQMGE SKSVTEVRNE
LKSVKDEIKA LQLTENELRH SQNQLSTKQR TLNEQLNKTR EEIAKLEKSM GSGSEEMIAQ
KSQLEEEVFR MQAEIESTND HLKDLHKEHS LLNTESQRKR KNFDQEIVKA KRTCEKILSC
VTALKNSHKH HRERYQEFSK ERAEKEKTDL QQQIKSNQDE LYGLIEVIEE LQSRRGEFEV
RKSKLQMART LLLKKTELDE HSLKYKQAKQ DFIEFNDSMG EDGIRGHLQP KLDEIRARRE
DIVDRRAKLE GEKTAKLEAI AETRSLEEDL GEDREREFFR STIRVRIEES FARDLDKFSK
ALGTAIIEVH QKQMTKLNSI ITSLWKTSYQ GSDIDTISIS AKDTRVGAST RSNMDYCVNM
HRPDGAVLSM RGRASAGQRM LASLVLRLAL METFSSSGIL TLDEPTTNLD KDAIRKFAET
VVSLAKTARG YNMKTQFIII THDKEFTEIL QDLATVEAAY RLEKSSGGYT VAKAMSEQTD
MDFDVYDTDD IYDRH
//
