ID E4XAX9_OIKDI Unreviewed; 677 AA.
AC E4XAX9;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=SCP2 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=GSOID_T00005729001 {ECO:0000313|EMBL:CBY08888.1};
OS Oikopleura dioica (Tunicate).
OC Eukaryota; Metazoa; Chordata; Tunicata; Appendicularia; Copelata;
OC Oikopleuridae; Oikopleura.
OX NCBI_TaxID=34765 {ECO:0000313|EMBL:CBY08888.1};
RN [1] {ECO:0000313|EMBL:CBY08888.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21097902; DOI=10.1126/science.1194167;
RA Denoeud F., Henriet S., Mungpakdee S., Aury J.M., Da Silva C.,
RA Brinkmann H., Mikhaleva J., Olsen L.C., Jubin C., Canestro C.,
RA Bouquet J.M., Danks G., Poulain J., Campsteijn C., Adamski M., Cross I.,
RA Yadetie F., Muffato M., Louis A., Butcher S., Tsagkogeorga G., Konrad A.,
RA Singh S., Jensen M.F., Cong E.H., Eikeseth-Otteraa H., Noel B.,
RA Anthouard V., Porcel B.M., Kachouri-Lafond R., Nishino A., Ugolini M.,
RA Chourrout P., Nishida H., Aasland R., Huzurbazar S., Westhof E., Delsuc F.,
RA Lehrach H., Reinhardt R., Weissenbach J., Roy S.W., Artiguenave F.,
RA Postlethwait J.H., Manak J.R., Thompson E.M., Jaillon O., Du Pasquier L.,
RA Boudinot P., Liberles D.A., Volff J.N., Philippe H., Lenhard B.,
RA Roest Crollius H., Wincker P., Chourrout D.;
RT "Plasticity of animal genome architecture unmasked by rapid evolution of a
RT pelagic tunicate.";
RL Science 330:1381-1385(2010).
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484}.
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DR EMBL; FN653033; CBY08888.1; -; Genomic_DNA.
DR AlphaFoldDB; E4XAX9; -.
DR InParanoid; E4XAX9; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000001307; Unassembled WGS sequence.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd03448; HDE_HSD; 1.
DR Gene3D; 1.10.287.4290; -; 1.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.1050.10; SCP2 sterol-binding domain; 1.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR039569; MaoC-like_dehydrat_N.
DR InterPro; IPR002539; MaoC-like_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR003033; SCP2_sterol-bd_dom.
DR InterPro; IPR036527; SCP2_sterol-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR45024; DEHYDROGENASES, SHORT CHAIN; 1.
DR PANTHER; PTHR45024:SF2; SCP2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00106; adh_short; 1.
DR Pfam; PF13452; MaoC_dehydrat_N; 1.
DR Pfam; PF01575; MaoC_dehydratas; 1.
DR Pfam; PF02036; SCP2; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF55718; SCP-like; 1.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 2.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Reference proteome {ECO:0000313|Proteomes:UP000001307}.
FT DOMAIN 328..409
FT /note="N-terminal of MaoC-like dehydratase"
FT /evidence="ECO:0000259|Pfam:PF13452"
FT DOMAIN 437..548
FT /note="MaoC-like"
FT /evidence="ECO:0000259|Pfam:PF01575"
FT DOMAIN 578..677
FT /note="SCP2"
FT /evidence="ECO:0000259|Pfam:PF02036"
SQ SEQUENCE 677 AA; 73663 MW; 5456308550185A7F CRC64;
MHGEGASSVA ADEVVAQIKA AGGNAMANYA NVCNTDDVLG PVMEEYGKLD ILINNAGILR
DRSFLRISDD DWQAIMDVHL TASFKLSQKA FEVMKAQKYG RIINTSSSSG IYGNFGQANY
AAAKMGLVGL TNTLAIEGRK NNVLCNAVAP QALSRMTENI FPADLHEMLG PQFVAPLTLY
LCHEDCNETG GVFETGGGYS SKLRFQSTKG ALFATKASYP TVEDVAAKFD EICNFDDEPE
AVESIHEATM RIMNAISEMP DAPEAAGDDP DADIQPNKAK AWKSDIVNWE YTHKDVILYN
LGVGASPMKD NCELRFIYEN HDEFQPLPSF AIVPAFKAIA ELGETPGLKV NLANILHGEQ
YIKLHKPFDA DGAKLSTTAK VGDILDKGKH LVYSTDYESR DEDGELVCTN QFVTFVRNQG
GFGGTNQQET IVEPIDAPDR EPDHTFEESV PLGQAALYRL SGDPNPLHLD PDFAQMAGFK
VPILHGMCTY GYAVRHIQNQ YPETPISAIK GRFSSPVLPG DTLVTKMWKD GEKVLFEVWN
KESNVKAISG GFVEFGFEES EKSSGSSESS RALLTDKLFA EMSDKVDASS VNKVKGIFKF
EIMEDGKLAK SWVVDLKNGE GSVSESDGKA DCTIIVSDSD FAAIAAGELD AQKAFFGGQM
KIKGNVMLSQ KLGTLLK
//
