ID   E4XAY8_OIKDI            Unreviewed;       641 AA.
AC   E4XAY8;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   22-FEB-2023, entry version 27.
DE   RecName: Full=Rho-GAP domain-containing protein {ECO:0000259|PROSITE:PS50238};
GN   ORFNames=GSOID_T00005738001 {ECO:0000313|EMBL:CBY08897.1};
OS   Oikopleura dioica (Tunicate).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Appendicularia; Copelata;
OC   Oikopleuridae; Oikopleura.
OX   NCBI_TaxID=34765 {ECO:0000313|EMBL:CBY08897.1};
RN   [1] {ECO:0000313|EMBL:CBY08897.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21097902; DOI=10.1126/science.1194167;
RA   Denoeud F., Henriet S., Mungpakdee S., Aury J.M., Da Silva C.,
RA   Brinkmann H., Mikhaleva J., Olsen L.C., Jubin C., Canestro C.,
RA   Bouquet J.M., Danks G., Poulain J., Campsteijn C., Adamski M., Cross I.,
RA   Yadetie F., Muffato M., Louis A., Butcher S., Tsagkogeorga G., Konrad A.,
RA   Singh S., Jensen M.F., Cong E.H., Eikeseth-Otteraa H., Noel B.,
RA   Anthouard V., Porcel B.M., Kachouri-Lafond R., Nishino A., Ugolini M.,
RA   Chourrout P., Nishida H., Aasland R., Huzurbazar S., Westhof E., Delsuc F.,
RA   Lehrach H., Reinhardt R., Weissenbach J., Roy S.W., Artiguenave F.,
RA   Postlethwait J.H., Manak J.R., Thompson E.M., Jaillon O., Du Pasquier L.,
RA   Boudinot P., Liberles D.A., Volff J.N., Philippe H., Lenhard B.,
RA   Roest Crollius H., Wincker P., Chourrout D.;
RT   "Plasticity of animal genome architecture unmasked by rapid evolution of a
RT   pelagic tunicate.";
RL   Science 330:1381-1385(2010).
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DR   EMBL; FN653033; CBY08897.1; -; Genomic_DNA.
DR   AlphaFoldDB; E4XAY8; -.
DR   InParanoid; E4XAY8; -.
DR   Proteomes; UP000001307; Unassembled WGS sequence.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR14963; RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED; 1.
DR   PANTHER; PTHR14963:SF7; RHO GTPASE-ACTIVATING PROTEIN 19; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001307}.
FT   DOMAIN          67..249
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          422..441
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          540..628
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        540..557
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   641 AA;  72782 MW;  16EBC01649404406 CRC64;
     MDDYNGVDRL LFFEEYLKRL RSEKEDFFKE TLERLLSTTL ELPFVEECRK LYIKERKPKK
     SGKCFGAPLN MYQFERLDPL IQTIRIDIHK EGLFRKPGAT ARKKELRRIL DAGEKPPTEI
     NVNDACDLVK IFFRELPYNI LPDEHFATHI SISDMNNGDG TEDKRRRIQT LQALYLCLPD
     VNRIGFRILL QLLHSTARRQ EENKMTASSL ATIFLPALLP QVVEHGSSAG ITKLSSHITF
     MIRHARKIIM PPIEIVNLVQ KFYPDCLKNM PPAPPATGKS RPGAKKTLSS RLKDSIVNFV
     SPKKGKRPPI RDANSISHTL LFRSGSADWT SSPRALDRQI RSKSEKILNR KSIFGSRSDI
     TDSELPTTCL HTENSEYAKF REIHSKETAS LGSMASLLSS AASNDIFDEA KADCVSRAST
     DYTEKSHEEL MSEEPTDERH SRVLIDRLSE ESTEDFHSAS VDEILDEDNP DESAESPPVC
     QVTRTKSATC LLSKKSSASS LSQYEQSATK SSMKECLDES TLEAPDIKIT SIADLVRMRQ
     QHKAESRENR RVLEPVRENS PARFSPKPPV KRESPTHPNV QREQKLQKTE NRSITLPRPI
     IRARNSPGLS SQRRDLRRNS STRMGPLAGM SIRQVKKETI L
//