ID E4XBB1_OIKDI Unreviewed; 603 AA.
AC E4XBB1;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Double-strand break repair protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=GSOID_T00005632001 {ECO:0000313|EMBL:CBY08794.1};
OS Oikopleura dioica (Tunicate).
OC Eukaryota; Metazoa; Chordata; Tunicata; Appendicularia; Copelata;
OC Oikopleuridae; Oikopleura.
OX NCBI_TaxID=34765 {ECO:0000313|EMBL:CBY08794.1};
RN [1] {ECO:0000313|EMBL:CBY08794.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21097902; DOI=10.1126/science.1194167;
RA Denoeud F., Henriet S., Mungpakdee S., Aury J.M., Da Silva C.,
RA Brinkmann H., Mikhaleva J., Olsen L.C., Jubin C., Canestro C.,
RA Bouquet J.M., Danks G., Poulain J., Campsteijn C., Adamski M., Cross I.,
RA Yadetie F., Muffato M., Louis A., Butcher S., Tsagkogeorga G., Konrad A.,
RA Singh S., Jensen M.F., Cong E.H., Eikeseth-Otteraa H., Noel B.,
RA Anthouard V., Porcel B.M., Kachouri-Lafond R., Nishino A., Ugolini M.,
RA Chourrout P., Nishida H., Aasland R., Huzurbazar S., Westhof E., Delsuc F.,
RA Lehrach H., Reinhardt R., Weissenbach J., Roy S.W., Artiguenave F.,
RA Postlethwait J.H., Manak J.R., Thompson E.M., Jaillon O., Du Pasquier L.,
RA Boudinot P., Liberles D.A., Volff J.N., Philippe H., Lenhard B.,
RA Roest Crollius H., Wincker P., Chourrout D.;
RT "Plasticity of animal genome architecture unmasked by rapid evolution of a
RT pelagic tunicate.";
RL Science 330:1381-1385(2010).
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DR EMBL; FN653033; CBY08794.1; -; Genomic_DNA.
DR AlphaFoldDB; E4XBB1; -.
DR InParanoid; E4XBB1; -.
DR Proteomes; UP000001307; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR CDD; cd00840; MPP_Mre11_N; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR007281; Mre11_DNA-bd.
DR InterPro; IPR041796; Mre11_N.
DR PANTHER; PTHR10139; DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11; 1.
DR PANTHER; PTHR10139:SF1; DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11; 1.
DR Pfam; PF00149; Metallophos; 1.
DR Pfam; PF04152; Mre11_DNA_bind; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001307}.
FT DOMAIN 27..268
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
FT DOMAIN 317..427
FT /note="Mre11 DNA-binding"
FT /evidence="ECO:0000259|Pfam:PF04152"
FT REGION 572..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 572..595
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 603 AA; 70321 MW; FD24CEF29E28DA83 CRC64;
MTGTKIKEKK LLEKSRSENI IEDEHTFKIL IATDTHIGYK STDEHRHDDS FNTMEEIFKI
YESAEPDFLL MGGDIFEKNN PAASVLERAI ELFMKYVPGE ANHKFELLSD AEKNFCCEGA
EVPNTLPRWL NGNFEVAKPI MTIHGNHDNP SGEFDNTVIE YLAELGLISQ FGRRTLLSDN
RLNVYPVLLQ KGKTKIAIYG WGWITDLRFR SMINLGTINF EVPEDVDDYF NILVVHQNRV
PRSSKTDFFA HTDIPEFIDY VLWGHEHDQK YDWYPGTRML IDQPGATVVT SLTNGEINQR
RIGMLTIRRR KNECYWRHDK IPLDTSRIFI FRDFVISDFL DLDEADAQIL KEKIRDLVVR
QIKDMKQEFD LKRQKFRKLA PEMPLLRLRI LQEAKIPKMK LTEFINHHDA RQYAINSDVV
SYKNPNTKKV KAGVFFGFED IDAAIFAEDQ QKILPMIEEI IAKREPLEFF NEIAMTNIIQ
GKLDECEQQE SFKGLNELPA RVKELKEYLY NRAEEKLLQA VDKKEIEIGA TVADCDRDIE
RFLKKMRIEE LKDYKPDAVL AEVREQAIQK KNAKIAQKKK TSEAKKSTEI SPPKAKRKYV
RKK
//
