ID   E4XCD4_OIKDI            Unreviewed;       857 AA.
AC   E4XCD4;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   RecName: Full=PIN domain-containing protein {ECO:0000259|SMART:SM00670};
GN   ORFNames=GSOID_T00007793001 {ECO:0000313|EMBL:CBY09259.1};
OS   Oikopleura dioica (Tunicate).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Appendicularia; Copelata;
OC   Oikopleuridae; Oikopleura.
OX   NCBI_TaxID=34765 {ECO:0000313|EMBL:CBY09259.1};
RN   [1] {ECO:0000313|EMBL:CBY09259.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21097902; DOI=10.1126/science.1194167;
RA   Denoeud F., Henriet S., Mungpakdee S., Aury J.M., Da Silva C.,
RA   Brinkmann H., Mikhaleva J., Olsen L.C., Jubin C., Canestro C.,
RA   Bouquet J.M., Danks G., Poulain J., Campsteijn C., Adamski M., Cross I.,
RA   Yadetie F., Muffato M., Louis A., Butcher S., Tsagkogeorga G., Konrad A.,
RA   Singh S., Jensen M.F., Cong E.H., Eikeseth-Otteraa H., Noel B.,
RA   Anthouard V., Porcel B.M., Kachouri-Lafond R., Nishino A., Ugolini M.,
RA   Chourrout P., Nishida H., Aasland R., Huzurbazar S., Westhof E., Delsuc F.,
RA   Lehrach H., Reinhardt R., Weissenbach J., Roy S.W., Artiguenave F.,
RA   Postlethwait J.H., Manak J.R., Thompson E.M., Jaillon O., Du Pasquier L.,
RA   Boudinot P., Liberles D.A., Volff J.N., Philippe H., Lenhard B.,
RA   Roest Crollius H., Wincker P., Chourrout D.;
RT   "Plasticity of animal genome architecture unmasked by rapid evolution of a
RT   pelagic tunicate.";
RL   Science 330:1381-1385(2010).
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DR   EMBL; FN653035; CBY09259.1; -; Genomic_DNA.
DR   AlphaFoldDB; E4XCD4; -.
DR   InParanoid; E4XCD4; -.
DR   Proteomes; UP000001307; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR   Gene3D; 3.40.50.1110; SGNH hydrolase; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR018834; DNA/RNA-bd_Est1-type.
DR   InterPro; IPR019458; Est1-like_N.
DR   InterPro; IPR045153; Est1/Ebs1-like.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR002716; PIN_dom.
DR   InterPro; IPR036514; SGNH_hydro_sf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR15696:SF0; PINC DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR15696; SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7; 1.
DR   Pfam; PF10374; EST1; 1.
DR   Pfam; PF10373; EST1_DNA_bind; 1.
DR   Pfam; PF13638; PIN_4; 1.
DR   SMART; SM00670; PINc; 1.
DR   SUPFAM; SSF88723; PIN domain-like; 1.
DR   SUPFAM; SSF52266; SGNH hydrolase; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001307}.
FT   DOMAIN          718..835
FT                   /note="PIN"
FT                   /evidence="ECO:0000259|SMART:SM00670"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   857 AA;  98128 MW;  817BDA617A78EA72 CRC64;
     MKINLESSIQ NFQNSHERDR VSKGSGPEKR RALDIFTQLV TFHPAFTMQE KVFDLVWKGI
     FYREVELYRK KLENASEEDA SAITVEFVDC LLLGVDYYND VVARCEEKFQ FTVKYHENHG
     IKVAQARHVK MCLYLCQQFF IHMGDLSRYI EQLDRSSTQR LSRKMPNSRD FYTSAKNLDP
     RHAKPHYQLG VLSTEQQRHF EAIIHYIRAA SVEKGGGSGT AMSLNKEFEM ARREAVSFLA
     RKEHQKELTK TLENRDVWFI KRKLPTMSKE QLNKRFKLTF LAALGRIFTG IDVALVKDFL
     EQAYSDLDAL ISMTKNGERP YIPAGFLVEL AIAAVFGMQQ SIERKQNEKD ALMMFFGLLA
     LLCRRLKNKL KSLMKSCPDG DIYIIGDGNC RLLAVDEIQN RTTHVYPNPG RTINEIKQRV
     EQFSINTGPT VPICILHAGN EDSSTINQTK PICEIVKDFR DLVSVVKSTF PNAAIYFSEI
     FPRWDQDKLR AEKLNAEIYK IAPELGIKFL YHKETFQKKD LFTFKDKELA ILSDKGKRKF
     SSVLTKCIEK ELSCHNDFAL ALENDQVSAL LPAMRILTEY LATHHQHSMF ASQKVSNLES
     VGSCGAIFSE LSNLICHKPL PVHVSLTTKN NQETVNCIET VDLQGFRPLR ESGIGSEWFG
     AKSNRLYENT VRMTVISKAL DEHAKEDNRV IRVHRHQFMP TELEKQSPTP VEERFLVKSV
     VPDTNCWIEK SDKLSKVLKL ENLKLEVFVS LCVKSELEGL TKSEKQKVAN QAKKSLELID
     EKKLRLLTST GVILAAGKTY SEAPQSNIRN DDIIKNSVKL ARNSVLLTDD KNLMLKSRSE
     KVPVMMVHHF LDWTSKA
//