ID E4XD72_OIKDI Unreviewed; 564 AA.
AC E4XD72;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 22-FEB-2023, entry version 35.
DE RecName: Full=DRBM domain-containing protein {ECO:0000259|PROSITE:PS50137};
GN ORFNames=GSOID_T00008110001 {ECO:0000313|EMBL:CBY24107.1};
OS Oikopleura dioica (Tunicate).
OC Eukaryota; Metazoa; Chordata; Tunicata; Appendicularia; Copelata;
OC Oikopleuridae; Oikopleura.
OX NCBI_TaxID=34765 {ECO:0000313|EMBL:CBY24107.1};
RN [1] {ECO:0000313|EMBL:CBY24107.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21097902; DOI=10.1126/science.1194167;
RA Denoeud F., Henriet S., Mungpakdee S., Aury J.M., Da Silva C.,
RA Brinkmann H., Mikhaleva J., Olsen L.C., Jubin C., Canestro C.,
RA Bouquet J.M., Danks G., Poulain J., Campsteijn C., Adamski M., Cross I.,
RA Yadetie F., Muffato M., Louis A., Butcher S., Tsagkogeorga G., Konrad A.,
RA Singh S., Jensen M.F., Cong E.H., Eikeseth-Otteraa H., Noel B.,
RA Anthouard V., Porcel B.M., Kachouri-Lafond R., Nishino A., Ugolini M.,
RA Chourrout P., Nishida H., Aasland R., Huzurbazar S., Westhof E., Delsuc F.,
RA Lehrach H., Reinhardt R., Weissenbach J., Roy S.W., Artiguenave F.,
RA Postlethwait J.H., Manak J.R., Thompson E.M., Jaillon O., Du Pasquier L.,
RA Boudinot P., Liberles D.A., Volff J.N., Philippe H., Lenhard B.,
RA Roest Crollius H., Wincker P., Chourrout D.;
RT "Plasticity of animal genome architecture unmasked by rapid evolution of a
RT pelagic tunicate.";
RL Science 330:1381-1385(2010).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FN653038; CBY24107.1; -; Genomic_DNA.
DR AlphaFoldDB; E4XD72; -.
DR InParanoid; E4XD72; -.
DR Proteomes; UP000001307; Unassembled WGS sequence.
DR GO; GO:0070877; C:microprocessor complex; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0031053; P:primary miRNA processing; IEA:InterPro.
DR CDD; cd19867; DSRM_DGCR8_rpt1; 1.
DR CDD; cd19868; DSRM_DGCR8_rpt2; 1.
DR Gene3D; 3.30.160.20; -; 2.
DR Gene3D; 3.30.160.590; -; 1.
DR InterPro; IPR040375; DGCR8.
DR InterPro; IPR014720; dsRBD_dom.
DR PANTHER; PTHR13482:SF3; MICROPROCESSOR COMPLEX SUBUNIT DGCR8; 1.
DR PANTHER; PTHR13482; MICRORNA PROCESSOR COMPLEX SUBUNIT DGCR8; 1.
DR Pfam; PF00035; dsrm; 2.
DR SMART; SM00358; DSRM; 2.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 2.
DR PROSITE; PS50137; DS_RBD; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001307};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}.
FT DOMAIN 294..362
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 142..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..38
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 564 AA; 64819 MW; 698FCD9A3EA0FEE3 CRC64;
MNEDEPSNKK RKVDENDEFS EASEDNREDG EIPDSDEDES PLNISTPNKS SEPTKPPITL
PVKCPFPCAL RLPVFLPLPQ TMSMSTPKPR SCPVVLPFLP HMMKGAAPPI PLPKPPVSAK
ESEKELEECY SKTAIPCLAY SKRSKPEENN PVEQNNDSTN VTITGETQQN EENKEENLVQ
AKIIHTENEH LDNQQIKEYV EKRFEYEEFQ GKRYKNQEAY NLSIVRRRQE REENRRNHRE
ENKRRRKQAR AEENSDERDD QDLPTLVKTC IEFKSREQKG RPSKNHTIYL QGKTTVTILH
EYCNRALKAQ PIYEDVRDDL VSSDRQKYII KIDGKEYGSG EGANRTIAKN IAALETLKLL
IPDFQPDDKF MLTGRAEQDY GYFNHLSITD NRLHQLCGQA GIPAPYQFLK DIIHKIHGPS
GAEEKLNISS NTPNNTTFHY TLGNDVVEGR ARSKKNAKHI AAQAMLAKLH PEFKTWGDLL
QNYSDLRSID PKLDQRTNQN DKNDDEEQIT TLFKEKNKGP NVALLSKLRE MMQKVAKENE
TRFAESDRIA PLFCENRVQL NSNF
//
