ID E4XEA7_OIKDI Unreviewed; 1250 AA.
AC E4XEA7;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 22-FEB-2023, entry version 30.
DE RecName: Full=chitin synthase {ECO:0000256|ARBA:ARBA00012543};
DE EC=2.4.1.16 {ECO:0000256|ARBA:ARBA00012543};
GN ORFNames=GSOID_T00008511001 {ECO:0000313|EMBL:CBY09510.1};
OS Oikopleura dioica (Tunicate).
OC Eukaryota; Metazoa; Chordata; Tunicata; Appendicularia; Copelata;
OC Oikopleuridae; Oikopleura.
OX NCBI_TaxID=34765 {ECO:0000313|EMBL:CBY09510.1};
RN [1] {ECO:0000313|EMBL:CBY09510.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21097902; DOI=10.1126/science.1194167;
RA Denoeud F., Henriet S., Mungpakdee S., Aury J.M., Da Silva C.,
RA Brinkmann H., Mikhaleva J., Olsen L.C., Jubin C., Canestro C.,
RA Bouquet J.M., Danks G., Poulain J., Campsteijn C., Adamski M., Cross I.,
RA Yadetie F., Muffato M., Louis A., Butcher S., Tsagkogeorga G., Konrad A.,
RA Singh S., Jensen M.F., Cong E.H., Eikeseth-Otteraa H., Noel B.,
RA Anthouard V., Porcel B.M., Kachouri-Lafond R., Nishino A., Ugolini M.,
RA Chourrout P., Nishida H., Aasland R., Huzurbazar S., Westhof E., Delsuc F.,
RA Lehrach H., Reinhardt R., Weissenbach J., Roy S.W., Artiguenave F.,
RA Postlethwait J.H., Manak J.R., Thompson E.M., Jaillon O., Du Pasquier L.,
RA Boudinot P., Liberles D.A., Volff J.N., Philippe H., Lenhard B.,
RA Roest Crollius H., Wincker P., Chourrout D.;
RT "Plasticity of animal genome architecture unmasked by rapid evolution of a
RT pelagic tunicate.";
RL Science 330:1381-1385(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-
CC D-glucosamine = [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) +
CC UDP; Xref=Rhea:RHEA:16637, Rhea:RHEA-COMP:9593, Rhea:RHEA-COMP:9595,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17029, ChEBI:CHEBI:57705,
CC ChEBI:CHEBI:58223; EC=2.4.1.16;
CC Evidence={ECO:0000256|ARBA:ARBA00000319};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FN653041; CBY09510.1; -; Genomic_DNA.
DR AlphaFoldDB; E4XEA7; -.
DR InParanoid; E4XEA7; -.
DR Proteomes; UP000001307; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004100; F:chitin synthase activity; IEA:UniProtKB-EC.
DR InterPro; IPR004835; Chitin_synth.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR22914; CHITIN SYNTHASE; 1.
DR PANTHER; PTHR22914:SF42; CHITIN SYNTHASE; 1.
DR Pfam; PF03142; Chitin_synth_2; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001307};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 39..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 249..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 313..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 403..423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 430..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 485..503
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 925..947
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 959..981
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 993..1014
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1020..1038
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1045..1068
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1250 AA; 143307 MW; DC911CC348B52D9A CRC64;
MRKRASIIEN EEPEKWDAAK VTTKEENTLP SLSLLFFKIF VRIICGLFLA FLVLTLGFTN
ICSLFSLISG IGVDFLHFNA EYVNRSSEYS FIKLNYFEAT QLVEENYVGD SCASRITFSE
SENGRLFKDI IVNKAMIANM RQLATTVTTM SFGAEHPCFL DELDSDQKLV HQALFLQGSF
TLLIALCLQE IRGIIVGLYF VIFKSKDVKN STKLENITQI VAELWNASAT AVLVFFVLPN
LIIYKLPYLF LHSVGILLLT SFIIRWRQKG MKLSCWLDII GVVFILGGIA LFILEHLLDD
EFQFKVGKDY PKILSLAAVL TVNINLIKNY SQLEPLRKDE GLAWVHLLAP FFRVGANVGV
FYLFIFASFS SSTILKNQYG NMIEFTNAGL ENLLSSDSGY SNWVTTCGVT AVLTSYLLSY
IIVSVTRTKL QLYAFVLPGI VLLLGMPMFF QFGIPALYKD ITEISLGLGK GFNTRGDGWF
EYFHLGQYAC GSLAFLLCVR HIFHDKSYPY GLERMLFDSP FYRPVWTLQS LFLHRRRHDI
SSFNLGDIED DGLKKDIENE TVPMIFICTT LWHEEDNEMK TLLTSILNLI EYVHSRENDK
DIPKNEKFNL EVNIFFDNVF ESHNSSKNPR LIRPSWLPES IDEWQTLNKW VYSFGKILAE
LLQNHNSCEE VIQKGRTIIT PYGGRLEYDI LGIKFHVHLK NADRVQRGKR WSMVMYLYYL
IGYKIDQCKM TVGPKNDQVT KDNSFILALD GDVHFRPEAV ELVLQRMKRN RTVGACCNQI
HPQGRGVLVW YQRFEYAVGH WLQKATEHVL GCVLCSPGCF SMMRMSFLSA DNVMALYKSI
ATTPMEKLMY DQGEDRWLCT LILLAGGRIE FESAAHCLTY APEDFDTYYK QRRRWGPSTT
ANIWELIKNK DIAVKSNAYI SRGYIAYQFF LLIFSVVGLS TTVMMVAEAF NMAVGESLSA
VWSYTLIVGP IVIYAILCRF YKNSDVQLSL AKVFSLIYSF IMALVLIFII KIGVDCWINP
TFLFFIGMAI LHIVVGVLHF DPITLLCGII YYLLIPTCFI FLQIYMIANL NDVSWGTRSG
PKKPAVKNPQ ESALGLFQRA KQVLCGVEPD QKRENETNAQ SPKEPVSQGG VKNLIVETKE
TLESYTNLRI QGPVLYGGVS IRNFRRQIGN RKKSDWDSND WNYFAKNLSK TTNIDQLECE
IIGDSRVNIS RRELNLMKEY NLKYFDWTLD RKAPLHRKWC YKNILLLFKR
//
