ID E4XNP2_OIKDI Unreviewed; 887 AA.
AC E4XNP2;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=Exocyst complex component 2 {ECO:0000256|ARBA:ARBA00017526, ECO:0000256|RuleBase:RU365069};
GN ORFNames=GSOID_T00016643001 {ECO:0000313|EMBL:CBY11480.1};
OS Oikopleura dioica (Tunicate).
OC Eukaryota; Metazoa; Chordata; Tunicata; Appendicularia; Copelata;
OC Oikopleuridae; Oikopleura.
OX NCBI_TaxID=34765 {ECO:0000313|EMBL:CBY11480.1};
RN [1] {ECO:0000313|EMBL:CBY11480.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21097902; DOI=10.1126/science.1194167;
RA Denoeud F., Henriet S., Mungpakdee S., Aury J.M., Da Silva C.,
RA Brinkmann H., Mikhaleva J., Olsen L.C., Jubin C., Canestro C.,
RA Bouquet J.M., Danks G., Poulain J., Campsteijn C., Adamski M., Cross I.,
RA Yadetie F., Muffato M., Louis A., Butcher S., Tsagkogeorga G., Konrad A.,
RA Singh S., Jensen M.F., Cong E.H., Eikeseth-Otteraa H., Noel B.,
RA Anthouard V., Porcel B.M., Kachouri-Lafond R., Nishino A., Ugolini M.,
RA Chourrout P., Nishida H., Aasland R., Huzurbazar S., Westhof E., Delsuc F.,
RA Lehrach H., Reinhardt R., Weissenbach J., Roy S.W., Artiguenave F.,
RA Postlethwait J.H., Manak J.R., Thompson E.M., Jaillon O., Du Pasquier L.,
RA Boudinot P., Liberles D.A., Volff J.N., Philippe H., Lenhard B.,
RA Roest Crollius H., Wincker P., Chourrout D.;
RT "Plasticity of animal genome architecture unmasked by rapid evolution of a
RT pelagic tunicate.";
RL Science 330:1381-1385(2010).
CC -!- FUNCTION: Component of the exocyst complex involved in the docking of
CC exocytic vesicles with fusion sites on the plasma membrane.
CC {ECO:0000256|ARBA:ARBA00002660, ECO:0000256|RuleBase:RU365069}.
CC -!- SUBUNIT: Component of the exocyst complex.
CC {ECO:0000256|RuleBase:RU365069}.
CC -!- SIMILARITY: Belongs to the SEC5 family. {ECO:0000256|ARBA:ARBA00010578,
CC ECO:0000256|RuleBase:RU365069}.
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DR EMBL; FN653085; CBY11480.1; -; Genomic_DNA.
DR AlphaFoldDB; E4XNP2; -.
DR InParanoid; E4XNP2; -.
DR Proteomes; UP000001307; Unassembled WGS sequence.
DR GO; GO:0000145; C:exocyst; IEA:UniProtKB-UniRule.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR GO; GO:0006893; P:Golgi to plasma membrane transport; IEA:UniProtKB-UniRule.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR029175; EXOC2/Sec5.
DR InterPro; IPR039481; EXOC2/Sec5_N_dom.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR PANTHER; PTHR13043:SF1; EXOCYST COMPLEX COMPONENT 2; 1.
DR PANTHER; PTHR13043; EXOCYST COMPLEX COMPONENT SEC5; 1.
DR Pfam; PF15469; Sec5; 2.
DR Pfam; PF01833; TIG; 1.
DR SUPFAM; SSF81296; E set domains; 1.
PE 3: Inferred from homology;
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483, ECO:0000256|RuleBase:RU365069};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|RuleBase:RU365069};
KW Reference proteome {ECO:0000313|Proteomes:UP000001307};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365069}.
FT DOMAIN 6..78
FT /note="IPT/TIG"
FT /evidence="ECO:0000259|Pfam:PF01833"
FT DOMAIN 127..397
FT /note="Exocyst complex component EXOC2/Sec5 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF15469"
FT DOMAIN 407..883
FT /note="Exocyst complex component EXOC2/Sec5 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF15469"
SQ SEQUENCE 887 AA; 99705 MW; A57CC711BC6E92F5 CRC64;
MSDVVPDVTG ISPKEAKPGT KLTIRGNNFG RSASDLVAVY VCGKNCSSSA EWQSERKIIC
RVAADCEGRG SVVVQTKRGP GKCQIQFTAL KSTPLGSLEQ SAVWVDEAPG AGAFSRSERG
SIRPTTQDPL GLKKIADRPL QTEHIRLFPG QSPDPGNEQF SPTWFLLHHH KSTSFQDLKK
GLVNLTQISR GGVVPQATTA QSASMSHIKD SLPIFFEVHE ALNSIHGQMS KGGQSSGMQN
AQQVKPDMTD NLLGLLKKAE SRSYNLFEDV LTQKDKADKI RNTLAVLQRF KLLFFLPGRV
NELKEDILDV DKFSQVVSDV DKVRSLFRDT KVPAFQKVMK ELNNSVGSLQ THLQEKLFES
SVRTDQNQTQ IVRQLIELGA TGDPTWDALQ TSLRSMRTKN FASLKKAQLR WDVETTSARR
ECISSFVEEI LILFKCVLPD LWKLWNRYSN GTLISNDPQQ SSKLKQLAST HAKDVKRLFS
DEILHGVSMI RAAVLHETLQ AKNATEAAER REYGIWPEPC QSAVNAATIN RLLQICREID
FKGIYGSDHI KELCFDFRVQ TIRLLMEELL EEIKSLKHQE DWELLADGGT NLPKMFVSAV
DEFCLLVREP VKRFASEENI FDRIQVETEL RSLMASILCQ FPVTLSQLAT MEAPQNLKKM
WPSGAMRLVT VLSNSIHSRV TKINHIEESL TKVGFPDARK VLFINLFIFN IFQVCVTVQR
KFAELDNRLI EGYLETRRDP IVCAVEPGMY AGMFDWGACP RPTQVRPYVK LCLIEVVAVH
AELHSVSQKL LASVLPKVID GLGDEFVRLL GSVSKFSAHG GLQARIEIRA IEECTALYSS
PRSKELFEEA LKLLPSVPGN EERQLEEQIM QNFRKQMHIQ LMALRDQ
//
