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Database: UniProt
Entry: E4XPI8_OIKDI
LinkDB: E4XPI8_OIKDI
Original site: E4XPI8_OIKDI 
ID   E4XPI8_OIKDI            Unreviewed;      4968 AA.
AC   E4XPI8;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   16-JAN-2019, entry version 39.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:CBY11776.1};
GN   ORFNames=GSOID_T00016960001 {ECO:0000313|EMBL:CBY11776.1};
OS   Oikopleura dioica (Tunicate).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Appendicularia; Oikopleuridae;
OC   Oikopleura.
OX   NCBI_TaxID=34765 {ECO:0000313|EMBL:CBY11776.1};
RN   [1] {ECO:0000313|EMBL:CBY11776.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21097902; DOI=10.1126/science.1194167;
RA   Denoeud F., Henriet S., Mungpakdee S., Aury J.M., Da Silva C.,
RA   Brinkmann H., Mikhaleva J., Olsen L.C., Jubin C., Canestro C.,
RA   Bouquet J.M., Danks G., Poulain J., Campsteijn C., Adamski M.,
RA   Cross I., Yadetie F., Muffato M., Louis A., Butcher S.,
RA   Tsagkogeorga G., Konrad A., Singh S., Jensen M.F., Cong E.H.,
RA   Eikeseth-Otteraa H., Noel B., Anthouard V., Porcel B.M.,
RA   Kachouri-Lafond R., Nishino A., Ugolini M., Chourrout P., Nishida H.,
RA   Aasland R., Huzurbazar S., Westhof E., Delsuc F., Lehrach H.,
RA   Reinhardt R., Weissenbach J., Roy S.W., Artiguenave F.,
RA   Postlethwait J.H., Manak J.R., Thompson E.M., Jaillon O.,
RA   Du Pasquier L., Boudinot P., Liberles D.A., Volff J.N., Philippe H.,
RA   Lenhard B., Roest Crollius H., Wincker P., Chourrout D.;
RT   "Plasticity of animal genome architecture unmasked by rapid evolution
RT   of a pelagic tunicate.";
RL   Science 330:1381-1385(2010).
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DR   EMBL; FN653094; CBY11776.1; -; Genomic_DNA.
DR   InParanoid; E4XPI8; -.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4769   4791       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4840   4866       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      118    173       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      180    225       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      231    289       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      295    360       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      362    418       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      634    833       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1056   1247       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     1359   1379       {ECO:0000256|SAM:Coils}.
FT   COILED     4334   4354       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4968 AA;  569223 MW;  11EB003EFC1C85B1 CRC64;
     MTELEEDDIF LRTDDKVYFQ FGQIITFILY FQCTKTHENK QDTTKICLAA GSFGTRICYA
     EKTQFSPVEG ENVGPPNTPE CVFVINQALS LRALHETLTH AKENNRPNQT SKTGPSHSKT
     LLYGNAVQLL HQTSGLYLCV LPTSQCTTDK LAFDVGLGDN PNDEAAWWTV SCASKNRSEG
     EKVRVSDDII LSSVSSERYL HLSNKNDVKV IEDDFQRSLW MIGPIQSEVK QGYVCGGDVL
     RLFHGRNSDD CLCNLDVNDV NIDPIRTAIY YEGGKVSIRA RSLWRVELTR IKWFGSHLHF
     GQQFRLRHMT SGKFLMMRAD RNLFIAEKDE HDWTDEASIF CFRQNKDKVE VSGEYEPESM
     GTEEIKYSES LVVLQHCASG LWVTYQAQEN SAKIGKQIRR AIAHPEGHMD DAFAVGRSQS
     TEAKTAMVML TTVTTIKKFL THMIKNFQKI KDLKAAANAV HFVPKGKANL EVPLDAMELL
     IQDCLVYFHP DEGETDEEKQ QIERLQRCQQ DLFQAEGIVD LLLKVIDKLT VYTATQHLQY
     LHKDQVERLE VLLVNVYKLL AGIIKKNRAN CAKFSKNLDW LIGQLDARQN ASAGILAVLS
     AVLDDSTEVL NMVKERHIVS IISLLERHGR NPLVLDVLQS LCVCNNIAVR SNQNLICNHL
     LSDRNLLLQT TMVNQIVSIR PNLFVGYGER SAQYRKWYFE VQVLQMDECS LSQATHLRVG
     WANTSGFAAY PGAGDGFGTC GVGDDLYSFG FDGLSLWTGH RSKYIKQGKV ELFKKCDIIS
     CCLDLSAPSM SFRKNGKPIH GMFERFNLEG MFFPCVSMSS GVVVKFLLGG KNGEFTFMPP
     PGYAPAHEAL LPERTLSVET VRGHYGVNDN WILNGPAKTL DQAVYTPDPI ETKNTELPKA
     LEPMLDKIAE NLHEIWAFNR IQGGWSFALV RDDQKKQNPS LTSFERLPES LRTFNMTMVE
     QNLRTIIALG YHVGLADEDA EYKLRKLKLP RQYLMTNGYK PAPLDLTHVR QSDKMEELVE
     LLATNSHNVW ASERIKQGWT YGFELDVKNK RNFRLVPFAL LDENAKQTNK NSIRELVITL
     MGYGYAIEAP DERMTTSSRK DDEQSDNPRF RMFRIESAYA VRSEKWYFEF EVQTDGEMRI
     GWAAPEVKAD EPIGLDNLSY TFDGFNAAKW HNGQEAYGKR WRVGDVIGCL LDFDEGFISF
     SLNGELMIDN QGAELAFNNI PDDIELVPVA YFDEGQQGIL NLGKNPDTFK FFQMYGVQEG
     FKPYCYQISY PLPIWYTKSL PSFSPIYKHD QLRTIRIQPG ITTPPILRLQ YKAFSSSSSR
     VVDMPNFIYS RLSMPVRILE TLKKAPSDRV NVFDAPEEVD QFDRDLDILK EREKEEKQAK
     PKVSLGLKQI LNRRGKKEEE EAELLLAAGA SQKHNRLKMD VLPSMTYNLG DYEHQNLLAG
     SRYVFSVRVF PGQEANNVWI GWVTPEYHSM NPSVFDDRHH IKNVTMTFGT ERGEIKETIC
     RSNAFLINAG MALSSQKSDK DMNAGSTSGG TIISCIVDVS SGLLKFRAGD KELDIVYQVE
     AMTQLYPACF FKPSTYNCIQ YELGRTKKEM PISAAMLKAD RKNVEPSCAP RLKAQKMQAV
     NWARMPQDCL TPIISRNRKT RDGWKVQIEK PMQFCAVFLP EENRSVDILE LTEHPSLLEF
     HLSTLNLYKA MCALGNFRVA HALCSYIDQQ QFLYCIKSSY LDGRLREVYH DLLIDIHLGA
     HANARQHTQG EFIIPLTEET KQVALYEDPE VKDPGLPGMG RFTSLRPDMR WKTANFVVPV
     QQYYTEVPAF PLDLLKHHVI ENLINAVSSQ TSPFKMYAGG SQEHLFVPLL KVCDKLLLMQ
     IFDDEDLEKL LTIIHSRYLG SKVEGYEELK YRVGEGLLQM RLCESIKLAL CSLLHHLCDY
     QLRHRIESLV SFAHVLAGEM QKNQRERYDE VMHSINMSAA MTAKMTKEFR SSPYDQAATI
     IRFKSEDDEL DSPCPTNIRH MMWNFHNDLM MHCGESIPEE DEEFEEYSMI NKIKRMGKAL
     YNCFSPKQEE FDDLEMVNIP IHNLQQLIAV TAVHWAEEAV IENPILVREI FALLHRQHDC
     VRELCRALEK TYCISEKSKN DTMELISDLS HIRSFLAVQM GKEEETMITQ DLSRIMNNCV
     FYQHPNLMRA LDMHTTVMDI MVNVLGASAE VGKQVSTAEV QFPKIVAVCS RFLGYFCRIS
     RVNQKAMFEH LSFLLDHSIF GLDTPSMRGC TPLDVAAASL VDNNELSLQI KETHVELVIK
     YLRTCGLQSS QTLLERNYPD IGWNPLEGER YLDFLKQVVF VSGESVEENA NLVVRHLIRK
     PECLGPALRG EGGQGLLAAM REAMEISKDP SRDTANNDAK RKIYQDEEND DEEEIHLGYC
     ILSFYSSLID LLGRCAPEQT LILQNKSEAL RIRSILQSLV PLEDLVGVIS LPFDLPRVEP
     ITETVIQPMM NSCFAPEHKA AMLLFLDRVY GIDDVEFLLR ILEDGFLNDI RAAAQLDTQQ
     LHVTDMALAL NRYVCSSILP IITKHVHLLA KAEHRDQLID SALHAIYRLS QGRAMTKAQK
     DFISECLCAI AGVIKPILMH NLLRKLTFDI PSLSQHVVVP IRMLTLHFER SWQYYCCPEG
     WGENGVASDE ERHLTMRLFW GLFEALVKNF DPNMVKWALP CLCAIGNALP PDYAVPSLVD
     DGARECQLDK NGNYDPKPIN TSGQRIDHRC DEFIERYSEH LHDIWASERM ANGWNYDPMF
     NDQTKEHPLI KPYANFSDRE KDVYRNNIRE AIRALQVWGW RVDRRGMHSG SGGPAEFGRR
     PSMSSKPDYV VDSSKGFTPK TTDLSGITLT REFTAIADSM AENFHNIWAK KKKIELEENG
     KSHPMFVPYD TLTAKEKEKY RNKAYDMLRF IQFSGFVLNK ASSDDNYDAR TSQERRFSFI
     LLHRLGEFLE LARNYVEELM VAITDQQLGD SLHFTSDSVK FFAKVVLPLI QSYFKAHQHY
     YVTPKSAKNI GISACNKEKE MIVTLFCALA ALMRRKVNFF GEDSEVTVDC LTNLTRCIDA
     ATVIKMGPDH VKSLLVVFFN DAAVDIELVL DSIRIWHLEK KSVALRAAHC WQYATQALIP
     ILTKFFNHVG DNEFGRDLLI EEMQVACYKI LNALYPLGTA KNHFVPHLKT KSAFGECLAA
     LANCFPVAFL EPRLNRYNTV SVYNALSIKD RQVLGLPNRI EELAPNLPTL KILLRDIEDL
     AVSGARYDDA PEMIDVILPV ICSYVPNWLE EGPEGKPELP NHCTEIGIKQ ANDTLGNVLR
     LIYNNLGTEE AQWMKSIANY TQPLMAKCGS DLLYSHFLPI LEKTLKKIER TAAIEEDIKS
     DQKIAVGDVS DLEMMMLEDF GFISRDIYAF YPLLVRFIDK NKMDWIATKN PEAESLFWKV
     SEIFVAWAKS VNFRREEQNY VVQNDIDNMS VITSDITAHK LRRHREKLKR RGEIYSWGTS
     LICVAPKRLL PVGLNVCVAG EHKIVQDAKI RLLKKESEAN VMYHIKEELE YMELEDEYEF
     SGDDLDKRAE IIFRLARIHC HLYKIEHPED KGRAVWEKLM SKSRKKAVVS CFRMTPLYNM
     PAHKVINVFI KSYNNLWLAT EDRDFANALI TALTKPQKTI GQEEIKPDDP PKALSDPLFQ
     IIQVQLNFFA FQTPANENIE ADPLYLHYAE LMARSIGPSE LEGGPDQEEE EEDDEDDGNF
     EDKEVEKQNL LFCQSRLHER GAAEMVLLVI SASNGKLCDM VVASLDLGIS LLQGGNETVQ
     RKMLMHLQEK RDSKFFTSLQ ALMQLCNVLD LDAYEHAENK GQQTKFTIML FRFLQLLCEG
     HNEDFQNYLR TQVGNNTSVN IVISTVDYLL RLQESVSDFY WYYSSKDQID DQGKEHFSSA
     IEMAKQVFNS LTEYIQGPCF LNQSSLAHSR LWDAVVGFWH VFAQLQSKLS KDSGNSLNLL
     SALLDLQQDM IVMLLSMLEG NIVNGNIGRQ LLDTLIEAQQ DVGLIIKYFT MFLKLSEVVE
     TEKFKEIDLE GKGIITKREF HKQLESAKNY DPEEIEYVLK CIQPDENDKF NYKDFVDQFH
     KPAEEIGFNF ALLLTSLHEH STNDNRLDKF LDIGKELLDY FDSNLGRIEI LGKSKRIERI
     YFNIQQSSLE QWEKPQIRDS KRAFIFDVIA EGGENGKMEE FVSFCENTIF EMQLAASISQ
     EGDEDGDENA EQGDNEDEEH DIQRHSFWDS VKHQFRIILG NISYFFTSKF FKKAFRTLRH
     TTVRDFVVFI FIVIYRAIKL FGRMLANICK FVGEWLLFYL FSSNLIDMMK ENTITGIIQA
     IPEPTQEGIG TRHEDDVAEE DDEEEEEEED IEEEDAPVIG EVFGITNKND STAAFTTYVE
     DKSWKGFGDQ DFDEAARNLG MEYDETAFNQ QVEAQAIRDR QRRNSEIGSA NKLKSNAKQS
     SWNNFDSDAG TWQTYRNPCL RPLKYTSIEE TKEEISPWKL KFQVFSTAFL AFFARNYYNF
     KSAALIISFL LNVILLSLRW ESEEELEVDE HVISEAEVLE NTLDDQEFGD QVNEVLVFSD
     WMFENVNEVF NWCAFLHTIL ALAKLVSYYE LKVPLLIFKR EKDISRKLEF EGLYVSCQPD
     EDDFTSMWDR LVISCPHFPM CYWDKFVKKK VLEKYGGQFE RDTVSELLGL DTSVNLNISP
     KERQEAENTE KQNKGPLAFI TDHDWRYGLW KTGVVLTDRT FLYLLGYTAF SFAGHFNRFF
     YAASLLDVAF DVKSLQTIMA SVTHNGKQFM LTVGLLVCVI YLYTVVAFNF FRDYYNKGED
     GEDDWKCQDM LSCFNFHLYA GLRAGGGIGD EMDPPGEDDF LARFAFDITF FFFIIVIILA
     IIQGLIIDAF GELRDQVEQV KDDMESKCFI CTLGKDFFDQ VPHGFDTHTM QEHNLANYLF
     FIMHLINKDK TEYTGQESYV WNLYQERCWD FFPVGDCFRK QNQEKGFE
//
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