ID E4XR39_OIKDI Unreviewed; 893 AA.
AC E4XR39;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:CBY12275.1};
GN ORFNames=GSOID_T00018154001 {ECO:0000313|EMBL:CBY12275.1};
OS Oikopleura dioica (Tunicate).
OC Eukaryota; Metazoa; Chordata; Tunicata; Appendicularia; Copelata;
OC Oikopleuridae; Oikopleura.
OX NCBI_TaxID=34765 {ECO:0000313|EMBL:CBY12275.1};
RN [1] {ECO:0000313|EMBL:CBY12275.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21097902; DOI=10.1126/science.1194167;
RA Denoeud F., Henriet S., Mungpakdee S., Aury J.M., Da Silva C.,
RA Brinkmann H., Mikhaleva J., Olsen L.C., Jubin C., Canestro C.,
RA Bouquet J.M., Danks G., Poulain J., Campsteijn C., Adamski M., Cross I.,
RA Yadetie F., Muffato M., Louis A., Butcher S., Tsagkogeorga G., Konrad A.,
RA Singh S., Jensen M.F., Cong E.H., Eikeseth-Otteraa H., Noel B.,
RA Anthouard V., Porcel B.M., Kachouri-Lafond R., Nishino A., Ugolini M.,
RA Chourrout P., Nishida H., Aasland R., Huzurbazar S., Westhof E., Delsuc F.,
RA Lehrach H., Reinhardt R., Weissenbach J., Roy S.W., Artiguenave F.,
RA Postlethwait J.H., Manak J.R., Thompson E.M., Jaillon O., Du Pasquier L.,
RA Boudinot P., Liberles D.A., Volff J.N., Philippe H., Lenhard B.,
RA Roest Crollius H., Wincker P., Chourrout D.;
RT "Plasticity of animal genome architecture unmasked by rapid evolution of a
RT pelagic tunicate.";
RL Science 330:1381-1385(2010).
CC -!- SIMILARITY: Belongs to the alpha-actinin family.
CC {ECO:0000256|ARBA:ARBA00010255}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FN653112; CBY12275.1; -; Genomic_DNA.
DR AlphaFoldDB; E4XR39; -.
DR InParanoid; E4XR39; -.
DR Proteomes; UP000001307; Unassembled WGS sequence.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd21214; CH_ACTN_rpt1; 1.
DR CDD; cd21216; CH_ACTN_rpt2; 1.
DR CDD; cd00051; EFh; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.60; -; 4.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR014837; EF-hand_Ca_insen.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF442; ALPHA-ACTININ, SARCOMERIC-RELATED; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF08726; EFhand_Ca_insen; 1.
DR Pfam; PF00435; Spectrin; 4.
DR SMART; SM00033; CH; 2.
DR SMART; SM00054; EFh; 2.
DR SMART; SM01184; efhand_Ca_insen; 1.
DR SMART; SM00150; SPEC; 3.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 4.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001307};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 37..141
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 150..257
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 752..787
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 788..823
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT COILED 272..299
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 437..471
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 893 AA; 103185 MW; 140FA5FA570ED84C CRC64;
MDPVNEYGYP VEDPDDPYMH QEEEWDREGL LDPAWERQQR KTFTAWCNSH LRKAGTGIEA
IDVDFRNGLK LMLLLEVISG ERLAKPDRGK MRFHKIANVN KALDFIESKG VRLVSIGAEE
IVDGNIKMTL GMIWTIILRF AIQDISVEET SAKEGLLLWC QRKTAPYKNV NVQNFHMSWK
DGLAFCALIH RHRPDILPNY DDLRKDDPMT NLNLAFDIAE KHLDIPKMLD AEDLVEVAKP
DERAVMTYVS CYYHAFSGQQ KAETAANRIL KVLDVNQANE KLMDEYERLA SDLMEWIERT
RPSLEDRTVE NQMSDVQTRL DQFRDYRRNQ KPPRSDQKGE LESSYNTLQT RLRLANRPAF
VPSEGRMVSD IASAWKGLEA AEKGYEEWLI AELRRLERLD HLAKKFYHKS QIHQSWTVGK
EDILKSEDYR SCNLSELKAL IKKHEAFESD LAAHQDRVEQ IAAIAQELND LDYHDCATIN
QKCQEICDEW DRLGEVTQRR RQSLENMEKI LDTIEQLYLE FAKRAAPFNN WMEGAKEDLE
DMFIVHSIEE IKGLIQAHEQ FKATLPEAQK EKDNIIGLMR EASKIARQYG VELGINPYTT
VSADSIEGAW NAVVNYIPRR DSSLQLELAK QQHHNQLRIK FAQQANAIGP WIQQKTEEIV
GVALEMDGTL EQQIQKLKSY QTAVEGYRPK VEELAHHHQE IQEALVFDNP HTNYTMEHIH
VGMEHLRTTI SRTINEIENQ IMMRDAKGLT AEQMNEFRAS FNHFDRKKKG YLEPDDFAAV
LISMGYQLGE AEFQRILAIV DPTGTGQVTF RSFIEFMTRE TTDNDTAEQV IESFRVLAGD
KPYILEEELK RELPPDQADY CIQRMSPFRG ADVPQGALDY ESFSTALYGE SDL
//
