ID E4Y0U1_OIKDI Unreviewed; 926 AA.
AC E4Y0U1;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=DRB sensitivity-inducing factor large subunit {ECO:0000256|ARBA:ARBA00029645};
GN ORFNames=GSOID_T00013777001 {ECO:0000313|EMBL:CBY15499.1};
OS Oikopleura dioica (Tunicate).
OC Eukaryota; Metazoa; Chordata; Tunicata; Appendicularia; Copelata;
OC Oikopleuridae; Oikopleura.
OX NCBI_TaxID=34765 {ECO:0000313|EMBL:CBY15499.1};
RN [1] {ECO:0000313|EMBL:CBY15499.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21097902; DOI=10.1126/science.1194167;
RA Denoeud F., Henriet S., Mungpakdee S., Aury J.M., Da Silva C.,
RA Brinkmann H., Mikhaleva J., Olsen L.C., Jubin C., Canestro C.,
RA Bouquet J.M., Danks G., Poulain J., Campsteijn C., Adamski M., Cross I.,
RA Yadetie F., Muffato M., Louis A., Butcher S., Tsagkogeorga G., Konrad A.,
RA Singh S., Jensen M.F., Cong E.H., Eikeseth-Otteraa H., Noel B.,
RA Anthouard V., Porcel B.M., Kachouri-Lafond R., Nishino A., Ugolini M.,
RA Chourrout P., Nishida H., Aasland R., Huzurbazar S., Westhof E., Delsuc F.,
RA Lehrach H., Reinhardt R., Weissenbach J., Roy S.W., Artiguenave F.,
RA Postlethwait J.H., Manak J.R., Thompson E.M., Jaillon O., Du Pasquier L.,
RA Boudinot P., Liberles D.A., Volff J.N., Philippe H., Lenhard B.,
RA Roest Crollius H., Wincker P., Chourrout D.;
RT "Plasticity of animal genome architecture unmasked by rapid evolution of a
RT pelagic tunicate.";
RL Science 330:1381-1385(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SPT5 family.
CC {ECO:0000256|ARBA:ARBA00006956}.
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DR EMBL; FN653533; CBY15499.1; -; Genomic_DNA.
DR AlphaFoldDB; E4Y0U1; -.
DR InParanoid; E4Y0U1; -.
DR Proteomes; UP000001307; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0032784; P:regulation of DNA-templated transcription elongation; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0140673; P:transcription elongation-coupled chromatin remodeling; IEA:InterPro.
DR CDD; cd06081; KOW_Spt5_1; 1.
DR CDD; cd06082; KOW_Spt5_2; 1.
DR CDD; cd06083; KOW_Spt5_3; 1.
DR CDD; cd06084; KOW_Spt5_4; 1.
DR CDD; cd06085; KOW_Spt5_5; 1.
DR CDD; cd06086; KOW_Spt5_6; 1.
DR CDD; cd09888; NGN_Euk; 1.
DR Gene3D; 2.30.30.30; -; 3.
DR Gene3D; 3.30.70.940; NusG, N-terminal domain; 1.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR041973; KOW_Spt5_1.
DR InterPro; IPR041975; KOW_Spt5_2.
DR InterPro; IPR041976; KOW_Spt5_3.
DR InterPro; IPR041977; KOW_Spt5_4.
DR InterPro; IPR041978; KOW_Spt5_5.
DR InterPro; IPR041980; KOW_Spt5_6.
DR InterPro; IPR005100; NGN-domain.
DR InterPro; IPR006645; NGN-like_dom.
DR InterPro; IPR036735; NGN_dom_sf.
DR InterPro; IPR039385; NGN_Euk.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR039659; SPT5.
DR InterPro; IPR017071; TF_Spt5_eukaryote.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR11125; SUPPRESSOR OF TY 5; 1.
DR PANTHER; PTHR11125:SF7; TRANSCRIPTION ELONGATION FACTOR SPT5; 1.
DR Pfam; PF00467; KOW; 1.
DR Pfam; PF03439; Spt5-NGN; 1.
DR PIRSF; PIRSF036945; Spt5; 1.
DR SMART; SM00739; KOW; 7.
DR SMART; SM00738; NGN; 1.
DR SUPFAM; SSF50104; Translation proteins SH3-like domain; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001307};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163}.
FT DOMAIN 33..124
FT /note="NusG-like N-terminal"
FT /evidence="ECO:0000259|SMART:SM00738"
FT DOMAIN 129..156
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 275..302
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 327..354
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 389..412
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 449..476
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 553..580
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 870..897
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT REGION 518..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 602..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 619..641
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 648..663
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 700..734
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 926 AA; 102208 MW; AD7D0F15FC7040B8 CRC64;
MRMLTKHADR RQEYDSFVDN DISENQLLPD VHDPNLWIVK CVIGTERENA LKLMKKFIFQ
QSKEAPLQIK SVIVPESAKG FIYIEAFKRT HVKQAVEGIN ALRPGVYDQQ MVPNTEMKDV
LRVIKTQAAL KEGMWVRMKR GIYKDDLAQV DYVEDSQNQV CVKMVPRIDM QKFRGFRASE
NKSRSRANAR PPQKLFNEDN IRAIGGEFTN DGDFLIFEGA RYSRKGYLYK TLKMDLIQIE
GVKPTLSELE KFEDDPNRAD VDFDPMGNKS GRSHNFAPGD MVIVSEGELA YLEGRIISIS
GNKITMMPKH EDLKEALEFP ANELRKLFKV GDHVKVITGR YEDETGLVVR VEENVVVVFS
DTTMHELKVR PEDLQACTEK SSGVDKMGKF KLGDMVQIDA QNVGVIVRLE KEAFQILNQR
GKQERFRSAT IQRRRDSHNA VALDGDQNPI RRNDKVKVID GPHVGKDGEV KHLYRGNCFI
YNRKHIDSGG MFVARARHLS LAGSNSGALA SNIVPMSPRI AQSPQRNDGG STPGRGTPGK
GPGASAQRSQ RDTKMIGQTI RIIKGPYKGH IGIVRDATPN DCQIELHSDC FKHITVKKAN
LKHVDSRGRG PGGNSTPFGR TPAHGSHTPA YHNSGSRTPA YGASTPRADG SRTPSQWDGG
RTPQYDGSRT PRGGENPWNS KVANTPRDDG FGDSFDTPGT PGTPYESRQS DYAPSPQYAP
QTPSYDQSST PYSMNPSPSP GPYSDTITPS PAYGSAGPTP SPGYFVNKKS IYKPTPSPGG
YDASPSPNAF TPMNYSPGMS PMFGQGDGNI NNVDWHSEDI EVSIKDSHDD ASHRGKTGII
KTISGHVSSV WVPDLDQTVS VGNDNLSPIQ PQKNHKVKVL HGDDQGHTGE LISIDGNDGI
VRMDADQQLK ILQLKFLGKI GTAGSS
//
