ID   E4ZK57_LEPMJ            Unreviewed;       625 AA.
AC   E4ZK57;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   RecName: Full=Carboxylic ester hydrolase {ECO:0000256|RuleBase:RU361235};
DE            EC=3.1.1.- {ECO:0000256|RuleBase:RU361235};
GN   ORFNames=LEMA_P071600.1 {ECO:0000313|EMBL:CBX91652.1};
OS   Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8)
OS   (Blackleg fungus) (Phoma lingam).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Leptosphaeriaceae;
OC   Plenodomus; Plenodomus lingam/Leptosphaeria maculans species complex.
OX   NCBI_TaxID=985895 {ECO:0000313|Proteomes:UP000002668};
RN   [1] {ECO:0000313|Proteomes:UP000002668}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8
RC   {ECO:0000313|Proteomes:UP000002668};
RX   PubMed=21326234; DOI=10.1038/ncomms1189;
RA   Rouxel T., Grandaubert J., Hane J.K., Hoede C., van de Wouw A.P.,
RA   Couloux A., Dominguez V., Anthouard V., Bally P., Bourras S.,
RA   Cozijnsen A.J., Ciuffetti L.M., Degrave A., Dilmaghani A., Duret L.,
RA   Fudal I., Goodwin S.B., Gout L., Glaser N., Linglin J., Kema G.H.J.,
RA   Lapalu N., Lawrence C.B., May K., Meyer M., Ollivier B., Poulain J.,
RA   Schoch C.L., Simon A., Spatafora J.W., Stachowiak A., Turgeon B.G.,
RA   Tyler B.M., Vincent D., Weissenbach J., Amselem J., Quesneville H.,
RA   Oliver R.P., Wincker P., Balesdent M.-H., Howlett B.J.;
RT   "Effector diversification within compartments of the Leptosphaeria maculans
RT   genome affected by Repeat-Induced Point mutations.";
RL   Nat. Commun. 2:202-202(2011).
CC   -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC       {ECO:0000256|ARBA:ARBA00005964, ECO:0000256|RuleBase:RU361235}.
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DR   EMBL; FP929072; CBX91652.1; -; Genomic_DNA.
DR   RefSeq; XP_003835017.1; XM_003834969.1.
DR   AlphaFoldDB; E4ZK57; -.
DR   STRING; 985895.E4ZK57; -.
DR   ESTHER; lepmc-e4zk57; Fungal_carboxylesterase_lipase.
DR   EnsemblFungi; CBX91652; CBX91652; LEMA_P071600.1.
DR   GeneID; 13287969; -.
DR   eggNOG; KOG4389; Eukaryota.
DR   HOGENOM; CLU_006586_10_7_1; -.
DR   InParanoid; E4ZK57; -.
DR   OMA; WAPTTEP; -.
DR   OrthoDB; 1845443at2759; -.
DR   Proteomes; UP000002668; Genome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002018; CarbesteraseB.
DR   InterPro; IPR019826; Carboxylesterase_B_AS.
DR   PANTHER; PTHR11559; CARBOXYLESTERASE; 1.
DR   PANTHER; PTHR11559:SF370; CARBOXYLIC ESTER HYDROLASE-RELATED; 1.
DR   Pfam; PF00135; COesterase; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   PROSITE; PS00122; CARBOXYLESTERASE_B_1; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361235};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002668};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        16..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          82..569
FT                   /note="Carboxylesterase type B"
FT                   /evidence="ECO:0000259|Pfam:PF00135"
SQ   SEQUENCE   625 AA;  69519 MW;  9D17248FE83A55B5 CRC64;
     MAIRPLNSSL IFDRRIILGL LAILVLAFTF AFLYSPDLRP RAAAWIPPLN SKPPTPAFVA
     PPKDPRDPNI VTLDYLAIRP NVTDTVRSYW NIPYAASTAG RNRFRGPQPV NRTYGLGRGE
     EPLVWDGSLG MCPRIQKRDA SLRNREDVAG EDVLGIKARI TEDCLSLNVF TPFDAEAGDD
     LPVLVNIPGG GFHLPGRSNG GEMVEKSRRE KGVEGKLDKG IIVVTMYYRN GIYGFLSGEQ
     IAKDGDYNNA LRDQRASLEW VQKYIRFFGG NPDHVVIMGT SAGGASVLLQ LTANDGDHHV
     PVPGTGRKPL FHGAIAQSPA SPTFFTPPQA EKFWNEVAGG LNCSDITCVR NASPGDLYYE
     NYPMSFPGRN TPPRWMWAPT TEPKGGMWTQ PAPAAILHNH YAKVPTLIGF TSNEGTDQVK
     KTTDNEGEFK SYLADHYPLL TDEDLDALVK LYPNDRHWPD SGKYWDAVAK AQGDIRYICP
     TYLASNAMAQ FNPPDVPTWQ YQWDVMWGVD ISNGFGTKHA GSVGQVMVRR ANAISDYFIS
     FAKHLDPNVD RGTGRPVWER LDREQGKRLF FTNIKEGGKR GDGEDMLGEV RMAVRGRDEA
     REKRCAVLRG MFRRLQMEGV EALEI
//