ID   E4ZLF6_LEPMJ            Unreviewed;       494 AA.
AC   E4ZLF6;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   RecName: Full=sphingosine kinase {ECO:0000256|ARBA:ARBA00044037};
DE            EC=2.7.1.91 {ECO:0000256|ARBA:ARBA00044037};
GN   ORFNames=LEMA_P050210.1 {ECO:0000313|EMBL:CBX92315.1};
OS   Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8)
OS   (Blackleg fungus) (Phoma lingam).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Leptosphaeriaceae;
OC   Plenodomus; Plenodomus lingam/Leptosphaeria maculans species complex.
OX   NCBI_TaxID=985895 {ECO:0000313|Proteomes:UP000002668};
RN   [1] {ECO:0000313|Proteomes:UP000002668}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8
RC   {ECO:0000313|Proteomes:UP000002668};
RX   PubMed=21326234; DOI=10.1038/ncomms1189;
RA   Rouxel T., Grandaubert J., Hane J.K., Hoede C., van de Wouw A.P.,
RA   Couloux A., Dominguez V., Anthouard V., Bally P., Bourras S.,
RA   Cozijnsen A.J., Ciuffetti L.M., Degrave A., Dilmaghani A., Duret L.,
RA   Fudal I., Goodwin S.B., Gout L., Glaser N., Linglin J., Kema G.H.J.,
RA   Lapalu N., Lawrence C.B., May K., Meyer M., Ollivier B., Poulain J.,
RA   Schoch C.L., Simon A., Spatafora J.W., Stachowiak A., Turgeon B.G.,
RA   Tyler B.M., Vincent D., Weissenbach J., Amselem J., Quesneville H.,
RA   Oliver R.P., Wincker P., Balesdent M.-H., Howlett B.J.;
RT   "Effector diversification within compartments of the Leptosphaeria maculans
RT   genome affected by Repeat-Induced Point mutations.";
RL   Nat. Commun. 2:202-202(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H(+);
CC         Xref=Rhea:RHEA:51496, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:76941, ChEBI:CHEBI:84410, ChEBI:CHEBI:456216;
CC         EC=2.7.1.91; Evidence={ECO:0000256|ARBA:ARBA00043822};
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DR   EMBL; FP929094; CBX92315.1; -; Genomic_DNA.
DR   RefSeq; XP_003835680.1; XM_003835632.1.
DR   AlphaFoldDB; E4ZLF6; -.
DR   STRING; 985895.E4ZLF6; -.
DR   EnsemblFungi; CBX92315; CBX92315; LEMA_P050210.1.
DR   GeneID; 13285274; -.
DR   eggNOG; KOG1116; Eukaryota.
DR   HOGENOM; CLU_013399_0_1_1; -.
DR   InParanoid; E4ZLF6; -.
DR   OMA; TMGNFYA; -.
DR   OrthoDB; 374620at2759; -.
DR   Proteomes; UP000002668; Genome.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.200.40; -; 1.
DR   InterPro; IPR017438; ATP-NAD_kinase_N.
DR   InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR   InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR   PANTHER; PTHR12358:SF31; LD11247P-RELATED; 1.
DR   PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR   Pfam; PF00781; DAGK_cat; 1.
DR   SMART; SM00046; DAGKc; 1.
DR   SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR   PROSITE; PS50146; DAGK; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:CBX92315.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002668};
KW   Transferase {ECO:0000313|EMBL:CBX92315.1}.
FT   DOMAIN          126..265
FT                   /note="DAGKc"
FT                   /evidence="ECO:0000259|PROSITE:PS50146"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          328..347
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        18..32
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   494 AA;  53629 MW;  19649E64B3C5A70C CRC64;
     MTTTAGHEDP FQDPVSATPQ PPSAIEANSS NAHVPDTLAV GRNASLTLGT DALIVLENIS
     TRSIPFYNVL WAEHSEDGQV TIQYAQPTSK KSVRPAIISY TLDKPDGRLS EAWIEKLLDR
     AYGVSQRRKR VKVLINPFGG QGGALKIYHK SIAPIFAAAR CELDVEKTQH NGHGVEIAQN
     LDIEAYDVVA CASGDGIPHE VWNGLGKRPD AARALVKIAV AQLPCGSGNA MSLNFNGTDD
     PSLATLAVVK GLRTPLDLAS ITQGNRRTLS FLSQSVGIVA ETDLATEHLR WMGSARFTWG
     FLVRLISQTI YPADIAVKVE NSTKPSVRDA YRAQASKPTR ATDDRPIPAT DAGLPALKYG
     TINDPLPSEW QLIPHDKLGN FYAGNLSYMS PDANFFPAAL PSDGCLDLVR IRGDIPRLTA
     IQTLLSVENH TFFDLPHVDY QKVSAYRIIP KNQEQGYISI DGERVPFEGF QCEVHRGLGT
     VLSLSGRLCE AKGV
//