ID E4ZW28_LEPMJ Unreviewed; 329 AA.
AC E4ZW28;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Similar to 3-hydroxyisobutyrate dehydrogenase {ECO:0000313|EMBL:CBX95804.1};
GN ORFNames=LEMA_P029560.1 {ECO:0000313|EMBL:CBX95804.1};
OS Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8)
OS (Blackleg fungus) (Phoma lingam).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Leptosphaeriaceae;
OC Plenodomus; Plenodomus lingam/Leptosphaeria maculans species complex.
OX NCBI_TaxID=985895 {ECO:0000313|Proteomes:UP000002668};
RN [1] {ECO:0000313|Proteomes:UP000002668}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8
RC {ECO:0000313|Proteomes:UP000002668};
RX PubMed=21326234; DOI=10.1038/ncomms1189;
RA Rouxel T., Grandaubert J., Hane J.K., Hoede C., van de Wouw A.P.,
RA Couloux A., Dominguez V., Anthouard V., Bally P., Bourras S.,
RA Cozijnsen A.J., Ciuffetti L.M., Degrave A., Dilmaghani A., Duret L.,
RA Fudal I., Goodwin S.B., Gout L., Glaser N., Linglin J., Kema G.H.J.,
RA Lapalu N., Lawrence C.B., May K., Meyer M., Ollivier B., Poulain J.,
RA Schoch C.L., Simon A., Spatafora J.W., Stachowiak A., Turgeon B.G.,
RA Tyler B.M., Vincent D., Weissenbach J., Amselem J., Quesneville H.,
RA Oliver R.P., Wincker P., Balesdent M.-H., Howlett B.J.;
RT "Effector diversification within compartments of the Leptosphaeria maculans
RT genome affected by Repeat-Induced Point mutations.";
RL Nat. Commun. 2:202-202(2011).
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DR EMBL; FP929127; CBX95804.1; -; Genomic_DNA.
DR RefSeq; XP_003839283.1; XM_003839235.1.
DR AlphaFoldDB; E4ZW28; -.
DR STRING; 985895.E4ZW28; -.
DR EnsemblFungi; CBX95804; CBX95804; LEMA_P029560.1.
DR GeneID; 13280969; -.
DR eggNOG; KOG0409; Eukaryota.
DR HOGENOM; CLU_035117_6_1_1; -.
DR InParanoid; E4ZW28; -.
DR OMA; YWVPSNS; -.
DR OrthoDB; 203032at2759; -.
DR Proteomes; UP000002668; Genome.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR22981; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED; 1.
DR PANTHER; PTHR22981:SF81; DEHYDROGENASE, PUTATIVE-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000002668}.
FT DOMAIN 1..138
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 176..302
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 182
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 329 AA; 35212 MW; 882A6FB948151BD4 CRC64;
MGYAMASNIR KKMPASSTLY INDINAAACT RFQNEYSTLG PIEILSTARE AADNAKVLIS
IVPAGVDVKK VYLDHETGVI AARKDKDRLI LECSTIDVET TKEVGKTLGD GGWGIYIDTP
VSGGVPAAQS GTLAMLIGYP SPPSEPSPST PYPHLLTPTL HMLGPPSKFH YLSTLGAGLT
AKIANNYLSG TILLATAEAL ALGTRHGLDP RALYAVIQSS TGQSWMCDHV CPIPNVQTQY
WVPSNSGYRP GFRTEMMVKD LDLGVRSAAE VGVEPTMARA ALAVWERAAV DERCRGRDGS
SVYLHVGGVL PEGYEDLGRK EGGEWVFGE
//
