ID E5A069_LEPMJ Unreviewed; 1585 AA.
AC E5A069;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=SPX domain-containing protein {ECO:0000259|PROSITE:PS51382};
GN ORFNames=LEMA_P100600.1 {ECO:0000313|EMBL:CBX96929.1};
OS Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8)
OS (Blackleg fungus) (Phoma lingam).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Leptosphaeriaceae;
OC Plenodomus; Plenodomus lingam/Leptosphaeria maculans species complex.
OX NCBI_TaxID=985895 {ECO:0000313|Proteomes:UP000002668};
RN [1] {ECO:0000313|Proteomes:UP000002668}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8
RC {ECO:0000313|Proteomes:UP000002668};
RX PubMed=21326234; DOI=10.1038/ncomms1189;
RA Rouxel T., Grandaubert J., Hane J.K., Hoede C., van de Wouw A.P.,
RA Couloux A., Dominguez V., Anthouard V., Bally P., Bourras S.,
RA Cozijnsen A.J., Ciuffetti L.M., Degrave A., Dilmaghani A., Duret L.,
RA Fudal I., Goodwin S.B., Gout L., Glaser N., Linglin J., Kema G.H.J.,
RA Lapalu N., Lawrence C.B., May K., Meyer M., Ollivier B., Poulain J.,
RA Schoch C.L., Simon A., Spatafora J.W., Stachowiak A., Turgeon B.G.,
RA Tyler B.M., Vincent D., Weissenbach J., Amselem J., Quesneville H.,
RA Oliver R.P., Wincker P., Balesdent M.-H., Howlett B.J.;
RT "Effector diversification within compartments of the Leptosphaeria maculans
RT genome affected by Repeat-Induced Point mutations.";
RL Nat. Commun. 2:202-202(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Vacuole membrane
CC {ECO:0000256|ARBA:ARBA00004128}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004128}.
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DR EMBL; FP929130; CBX96929.1; -; Genomic_DNA.
DR RefSeq; XP_003840408.1; XM_003840360.1.
DR STRING; 985895.E5A069; -.
DR EnsemblFungi; CBX96929; CBX96929; LEMA_P100600.1.
DR GeneID; 13283690; -.
DR eggNOG; KOG1161; Eukaryota.
DR eggNOG; KOG4580; Eukaryota.
DR HOGENOM; CLU_249242_0_0_1; -.
DR InParanoid; E5A069; -.
DR OMA; THHHANA; -.
DR OrthoDB; 11387at2759; -.
DR Proteomes; UP000002668; Genome.
DR GO; GO:0000776; C:kinetochore; IEA:InterPro.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034508; P:centromere complex assembly; IEA:InterPro.
DR CDD; cd22647; CTF3_NTD_HEAT; 1.
DR CDD; cd07892; PolyPPase_VTC2-3_like; 1.
DR CDD; cd14480; SPX_VTC2_like; 1.
DR Gene3D; 3.20.100.30; VTC, catalytic tunnel domain; 1.
DR InterPro; IPR012485; CENP-I.
DR InterPro; IPR003807; DUF202.
DR InterPro; IPR004331; SPX_dom.
DR InterPro; IPR018966; VTC_domain.
DR InterPro; IPR042267; VTC_sf.
DR PANTHER; PTHR46140; VACUOLAR TRANSPORTER CHAPERONE 1-RELATED; 1.
DR PANTHER; PTHR46140:SF2; VACUOLAR TRANSPORTER CHAPERONE 2-RELATED; 1.
DR Pfam; PF07778; CENP-I; 1.
DR Pfam; PF02656; DUF202; 1.
DR Pfam; PF09359; VTC; 1.
DR PROSITE; PS51382; SPX; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002668};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Vacuole {ECO:0000256|ARBA:ARBA00022554}.
FT TRANSMEM 1469..1487
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1499..1517
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1537..1557
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 771..950
FT /note="SPX"
FT /evidence="ECO:0000259|PROSITE:PS51382"
FT REGION 853..897
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1338..1402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 862..878
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1372..1386
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1585 AA; 177865 MW; 957B16498C7DF686 CRC64;
MPSVAEEPLA LDSALDLLHE GMVCMRLYYR GRHLQCTAAS RLPAKSRSVK VSGLVDVVCR
HALDHGLDQD ALRDVVQLVS VKTTLDQSSV TTLIKNLYPA QRIPKDVVIA VVGALGQGKG
KPSLGTQDSL VKWLTIVHEI IEDPGVLSRL YSVLFGMLDM ISIRTSLCYL LSLLTRRKHV
KPFRIQQLLE ISRGIGNEPA LQGLLRVYKD YYPDIILGST STSRKSFAPQ PDEEWRTRIA
AVQEASVAAD DNVADRYNGF KVLRKGPRRG KSSAIPEVHT YQTTETSVTL EGIDNVEDFV
ERLDTIEPPG QLISLLTDPL LQKYVDLKPT PITTARISLW LATCLEDQYL GARLGNGESQ
YLSELLQGLL RHTQYSKTLH PTVLAFLERY ISIWDGMDNV DAVLGLLSYM PIISFKDAYQ
SYIAPIEQAL SHHDIATYTK VIEFYTKLLQ HQVCLVSSQR ERSKYATKHV ISDLTSHVPI
LSTSLRLSTP PAFLNTLTSS VLSFYELLSS SSRTKTNAPP PVPITLPPPH LIYLLAQDES
LTTISRICGI LGAYKNAFDS HPKPVSRYYA ESVTNTFNTC LRDIYNTLWV SKALVAAEGK
SVGLYCMPEL RLQLHEYLST IDRSYTIETA FGLSNNACLS SLSAAAWHEL EKREMERRGG
DVNSVVHNIG PIHKATLDRL KREGVMSVEW DGPDGYKVHV LRWLEERGLG GIKGLMFAIA
TNLRGKLLQA SRQPVIVVPS RAFSVDYCRF LILGGLPCFQ GAIHGTNHAA MKFGTTLRKS
VYEPWKDKYI DYDKLKKLLK DNEDDDSWTA DDESAFVDEL ANVQLEKVHN FIKDISQKLR
DRTSACEKKL EPLAIGIKGP GDDEAKGSDN KGEGEGETKS AQTGDAPKKP QPSQAEQQRI
LKEVLAELDT ITKETKELEG FSRLNFTAVI KATKKHDKLR GASYRLRPFI DARIARHPLH
TEDASPLLYR LSALYSFVRQ SLEGKSKDAL SFGEGTTDGE GYRSHKFWVH MDNLFEVKTV
ILRRLPVLVY NPQTSKIAEG SQRDPTITSI YFDNPNFSLY TDKVNGKPNA SSLRLRWYGQ
LNEKPEILFE KKVIKEGDVS EEIRFPIKAK YVQAFLEDKY HMEKSIEKME YRPNKDQKQL
DSFKQAVQDI QGFVKTQKLQ PVLRANYTRT AFQIPGDNRI RISLDTNLAL IREDALDLDR
PCREPDDWHR RDIDNANMEY PFKAIKKGEL HKFPYALLEI KVKGLKKYEW IEDLMNSHLV
KESPRFSKFV HGVAKLFEDN VNTFPFWLSE VDNDIRKAPE EAFDNEQERK RKAAEDDFAV
GSLFGARASP SYRASIVSPV GSPAGARSGP KSASAAAHSM PVVKPPLPTI GSHLSGQFQQ
ENNTGRVNEE VDSDEDDTQP LTKSIRSSGF ASLFPGFSTS KYARKQARNG LTPNRTNLPP
GIRDPGVWIK DQGAVRVEPK VWLANQRTFI KWQHVSVLLA SLSLGLYNAA GEGNDIARAL
AVVYTCVAAF TLAWGYGIYM YRERLIRERS GRDFDAITGP LVVCVGLGVA LVLNFGFKYK
ALLEEKRNHG ALNTTFGAEQ MELRI
//
